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    Hs3st6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 [ Mus musculus (house mouse) ]

    Gene ID: 328779, updated on 5-Mar-2024

    Summary

    Official Symbol
    Hs3st6provided by MGI
    Official Full Name
    heparan sulfate (glucosamine) 3-O-sulfotransferase 6provided by MGI
    Primary source
    MGI:MGI:3580487
    See related
    Ensembl:ENSMUSG00000039628 AllianceGenome:MGI:3580487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3-OST-6
    Summary
    Enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Acts upstream of or within blastocyst hatching. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Is expressed in alimentary system; early conceptus; integumental system; and nervous system. Orthologous to human HS3ST6 (heparan sulfate-glucosamine 3-sulfotransferase 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in mammary gland adult (RPKM 10.9), genital fat pad adult (RPKM 9.3) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    17 A3.3; 17 12.53 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24971565..24977664)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24752988..24758690)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E265 Neighboring gene ribosomal protein L3-like Neighboring gene methionine sulfoxide reductase B1 Neighboring gene meiosis specific with OB domains Neighboring gene STARR-positive B cell enhancer ABC_E486 Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene fumarylacetoacetate hydrolase domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    heparan sulfate glucosamine 3-O-sulfotransferase 6
    Names
    heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6
    NP_001012402.1
    NP_001344269.1
    NP_001344271.1
    XP_006524490.1
    XP_030105708.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012402.2NP_001012402.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform 1

      See identical proteins and their annotated locations for NP_001012402.1

      Status: VALIDATED

      Source sequence(s)
      AK146974, AY574375
      Consensus CDS
      CCDS28496.1
      UniProtKB/Swiss-Prot
      Q5GFD5
      UniProtKB/TrEMBL
      A2RTI7, B7ZNT8
      Related
      ENSMUSP00000040919.7, ENSMUST00000044922.8
      Conserved Domains (1) summary
      pfam00685
      Location:91326
      Sulfotransfer_1; Sulfotransferase domain
    2. NM_001357340.1NP_001344269.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK146974, AY574375
      UniProtKB/TrEMBL
      Q3UIC7
      Conserved Domains (1) summary
      pfam00685
      Location:30186
      Sulfotransfer_1; Sulfotransferase domain
    3. NM_001357342.1NP_001344271.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154566, AY574375
      UniProtKB/TrEMBL
      Q3UIC7
      Conserved Domains (1) summary
      pfam00685
      Location:30186
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24971565..24977664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249848.2XP_030105708.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform X1

      Conserved Domains (1) summary
      pfam00685
      Location:51207
      Sulfotransfer_1; Sulfotransferase domain
    2. XM_006524427.5XP_006524490.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform X2

      See identical proteins and their annotated locations for XP_006524490.1

      UniProtKB/TrEMBL
      Q3UIC7
      Conserved Domains (1) summary
      pfam00685
      Location:30186
      Sulfotransfer_1; Sulfotransferase domain