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    Tnfrsf22 tumor necrosis factor receptor superfamily, member 22 [ Mus musculus (house mouse) ]

    Gene ID: 79202, updated on 24-Feb-2024

    Summary

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    Official Symbol
    Tnfrsf22provided by MGI
    Official Full Name
    tumor necrosis factor receptor superfamily, member 22provided by MGI
    Primary source
    MGI:MGI:1930270
    See related
    Ensembl:ENSMUSG00000010751 AllianceGenome:MGI:1930270
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SOBa; Tnfrh2; Tnfrsf1al2; mDcTrailr2; 2810028K06Rik; C130035G06Rik
    Summary
    Enables TRAIL binding activity. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Located in external side of plasma membrane. Is expressed in embryo; heart; liver; placenta; and trunk. Human ortholog(s) of this gene implicated in carcinoma (multiple); cervical cancer; hematologic cancer (multiple); and urinary bladder cancer. Orthologous to human TNFRSF10A (TNF receptor superfamily member 10a) and TNFRSF10C (TNF receptor superfamily member 10c). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 3.9), subcutaneous fat pad adult (RPKM 2.4) and 25 other tissues See more
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    Genomic context

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    Location:
    7 F5; 7 88.27 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143188540..143203412, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143634808..143649675, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1098 Neighboring gene predicted gene 15579 Neighboring gene tumor necrosis factor receptor superfamily, member 26 Neighboring gene RIKEN cDNA E230032D23 gene Neighboring gene STARR-positive B cell enhancer ABC_E6618 Neighboring gene STARR-seq mESC enhancer starr_20534 Neighboring gene tumor necrosis factor receptor superfamily, member 23 Neighboring gene STARR-positive B cell enhancer ABC_E10486 Neighboring gene oxysterol binding protein-like 5 Neighboring gene STARR-positive B cell enhancer ABC_E2256 Neighboring gene STARR-positive B cell enhancer ABC_E3762

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transmembrane TNF and Partially TNFR1 Regulate TNFR2 Expression and Control Inflammation in Mycobacterial-Induced Pleurisy. Uysal H, et al. Int J Mol Sci, 2018 Jul 4. PMID 29973541, Free PMC Article
    2. A genomic reservoir for Tnfrsf genes is developmentally regulated and imprinted in the mouse. de la Casa Esperón E, et al. Epigenetics, 2012 Jun 1. PMID 22595876, Free PMC Article
    3. The Tnfrh1 (Tnfrsf23) gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface. Clark L, et al. BMC Genet, 2002 Jun 27. PMID 12102730, Free PMC Article
    4. Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Schneider P, et al. J Biol Chem, 2003 Feb 14. PMID 12466268
    5. Gene density and transcription influence the localization of chromatin outside of chromosome territories detectable by FISH. Mahy NL, et al. J Cell Biol, 2002 Dec 9. PMID 12473685, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transmembrane TNF, TNFR2 and TNFR1 (indirectly) are critical for preventing inflammation during BCG-induced pleurisy in mice.
      Title: Transmembrane TNF and Partially TNFR1 Regulate TNFR2 Expression and Control Inflammation in Mycobacterial-Induced Pleurisy.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables TRAIL binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 22
    Names
    TNF receptor family member SOBa
    TNF receptor homolog 2
    decoy TRAIL receptor 2
    tumor necrosis factor receptor p60 homolog 2
    tumor necrosis factor receptor superfamily, member 1a-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311145.2 → NP_001298074.1  tumor necrosis factor receptor superfamily member 22 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001298074.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate 3' exon, compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC068006
      Consensus CDS
      CCDS80846.1
      UniProtKB/Swiss-Prot
      Q8VHB9, Q9CZA4, Q9ER62
      Related
      ENSMUSP00000075018.7, ENSMUST00000075588.13
      Conserved Domains (1) summary
      cd15837
      Location:48 → 165
      TNFRSF26; Tumor necrosis factor receptor superfamily member 26 (TNFRSF26), also known as tumor necrosis factor receptor homolog 3 (TNFRH3)

    2. NM_023680.5 → NP_076169.2  tumor necrosis factor receptor superfamily member 22 isoform 1 precursor

      See identical proteins and their annotated locations for NP_076169.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AC068006
      Consensus CDS
      CCDS22043.1
      UniProtKB/Swiss-Prot
      Q9ER62
      Related
      ENSMUSP00000119297.2, ENSMUST00000146692.8
      Conserved Domains (1) summary
      cd15837
      Location:48 → 165
      TNFRSF26; Tumor necrosis factor receptor superfamily member 26 (TNFRSF26), also known as tumor necrosis factor receptor homolog 3 (TNFRH3)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      143188540..143203412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243119.2 → XP_030098979.1  tumor necrosis factor receptor superfamily member 22 isoform X1

      Conserved Domains (1) summary
      cd15837
      Location:48 → 165
      TNFRSF26; Tumor necrosis factor receptor superfamily member 26 (TNFRSF26), also known as tumor necrosis factor receptor homolog 3 (TNFRH3)

    RNA

    1. XR_003946601.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_176977.1: Suppressed sequence

      Description
      NM_176977.1: This RefSeq was removed because it is completely UTR sequence.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ER62.3 GenPept UniProtKB/Swiss-Prot:Q9ER62

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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