EIF3E eukaryotic translation initiation factor 3 subunit E [Homo sapiens (human)] - Gene

Summary

Official Symbol: EIF3Eprovided by HGNC
Official Full Name: eukaryotic translation initiation factor 3 subunit Eprovided by HGNC
Primary source: HGNC:HGNC:3277
See related: Ensembl:ENSG00000104408 MIM:602210; AllianceGenome:HGNC:3277
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: INT6; EIF3S6; EIF3-P48; eIF3-p46
Summary: Enables protein N-terminus binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of mRNA binding activity; regulation of gene expression; and translational initiation. Located in cytosol and nucleus. Part of eukaryotic translation initiation factor 3 complex. Colocalizes with PML body. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary (RPKM 226.7), lymph node (RPKM 138.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q23.1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (108201216..108248717, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (109329722..109377212, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (109213445..109260946, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-335-3p inhibits cell proliferation and induces cell cycle arrest and apoptosis in acute myeloid leukemia by targeting EIF3E.
Title: MiR-335-3p inhibits cell proliferation and induces cell cycle arrest and apoptosis in acute myeloid leukemia by targeting EIF3E.
eIF3 Associates with 80S Ribosomes to Promote Translation Elongation, Mitochondrial Homeostasis, and Muscle Health.
Title: eIF3 Associates with 80S Ribosomes to Promote Translation Elongation, Mitochondrial Homeostasis, and Muscle Health.
An EIF3E-RSPO2 fusion was detected in three colorectal serrated polyps
Title: EIF3E-RSPO2 and PIEZO1-RSPO2 fusions in colorectal traditional serrated adenoma.
Data suggest that decreased eukaryotic translation initiation factor 3 subunit e expression may pave way for epithelial-mesenchymal transition in the development of adenomyosis through activating the TGF-beta1 signaling pathway.
Title: The Possible Role of Eukaryotic Translation Initiation Factor 3 Subunit e (eIF3e) in the Epithelial-Mesenchymal Transition in Adenomyosis.
These data suggest that eIF3e downregulation may be involved in epithelial-mesenchymal transition in endometriosis, possibly through preferential translation of Snail.
Title: Reduced Expression of Eukaryotic Translation Initiation Factor 3 Subunit e and Its Possible Involvement in the Epithelial-Mesenchymal Transition in Endometriosis.
A transcript-specific eIF3 complex mediates global translational control of energy metabolism.
Title: A Transcript-Specific eIF3 Complex Mediates Global Translational Control of Energy Metabolism.
INT6 protects against breast cancer by showing how it functions in DSB repair, with potential clinical implications for cancer therapy.
Title: INT6/EIF3E Controls the RNF8-Dependent Ubiquitylation Pathway and Facilitates DNA Double-Strand Break Repair in Human Cells.
eIF3e is an angiogenesis suppressor. Silencing of eIF3e promotes blood perfusion recovery after limb ischemia through stabilization of hypoxia-inducible factor 2alpha activity.
Title: Silencing of eIF3e promotes blood perfusion recovery after limb ischemia through stabilization of hypoxia-inducible factor 2α activity.
High eIF3e expression may contribute to tumor progression and predict poor prognosis in colon cancer.
Title: Overexpression of eIF3e is correlated with colon tumor development and poor prognosis.
Int6/eIF3e is essential for proliferation and survival of human glioblastoma cells.
Title: Int6/eIF3e is essential for proliferation and survival of human glioblastoma cells.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine. EBI GWAS Catalog EBI GWAS CatalogPubMed
Wnt signaling and Dupuytren's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 3 subunit E protein (EIF3E), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Gag-Pol	gag-pol	Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 3 subunit E protein (EIF3E), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Nef	nef	Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 3 subunit E protein (EIF3E), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Pol	gag-pol	HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit E (EIF3E) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed
Pr55(Gag)	gag	Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 3 subunit E protein (EIF3E), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
retropepsin	gag-pol	HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit E (EIF3E) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-79010 (e-PCR)
- UniSTS:101390

RH47662 (e-PCR)
- UniSTS:32

STS-N21321 (e-PCR)
- UniSTS:74024

G19931 (e-PCR)
- UniSTS:21572

A002C29 (e-PCR)
- UniSTS:21573

RH118844 (e-PCR)
- UniSTS:138826

RH27221 (e-PCR)
- UniSTS:90229

RH44515 (e-PCR)
- UniSTS:53151

RH36368 (e-PCR)
- UniSTS:47020

ECD12775 (e-PCR)
- UniSTS:293807

REN32267 (e-PCR)
- UniSTS:357067

REN32268 (e-PCR)
- UniSTS:357068

D6S1876 (e-PCR)
- UniSTS:68852

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables cadherin binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to translation initiation factor activity	IC Inferred by Curator more info	PubMed
enables translation initiation factor activity	IC Inferred by Curator more info	PubMed
contributes_to translation initiation factor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in formation of cytoplasmic translation initiation complex	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of translational initiation	NAS Non-traceable Author Statement more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mRNA binding	IPI Inferred from Physical Interaction more info	PubMed
involved_in positive regulation of translation	IPI Inferred from Physical Interaction more info	PubMed
involved_in regulation of translational initiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of translational initiation	NAS Non-traceable Author Statement more info	PubMed
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IC Inferred by Curator more info	PubMed
involved_in translational initiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with PML body	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin	NAS Non-traceable Author Statement more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
part_of eukaryotic 43S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 48S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 3 complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 3 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of eukaryotic translation initiation factor 3 complex	NAS Non-traceable Author Statement more info	PubMed
part_of eukaryotic translation initiation factor 3 complex, eIF3e	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in membrane	HDA more info	PubMed
located_in nucleoplasm	NAS Non-traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 3 subunit E

Names: eIF-3 p48; eukaryotic translation initiation factor 3 subunit 6; eukaryotic translation initiation factor 3, subunit 6 (48kD); eukaryotic translation initiation factor 3, subunit 6 48kDa; mammary tumor-associated protein INT6; murine mammary tumor integration site 6 (oncogene homolog); viral integration site protein INT-6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.