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    Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha [ Mus musculus (house mouse) ]

    Gene ID: 71978, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ppp2r2aprovided by MGI
    Official Full Name
    protein phosphatase 2, regulatory subunit B, alphaprovided by MGI
    Primary source
    MGI:MGI:1919228
    See related
    Ensembl:ENSMUSG00000022052 AllianceGenome:MGI:1919228
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1541; 2410004D02Rik
    Summary
    Predicted to enable protein phosphatase 2A binding activity; protein phosphatase regulator activity; and tau protein binding activity. Acts upstream of or within response to morphine. Located in synapse. Is active in glutamatergic synapse. Is expressed in eye. Orthologous to human PPP2R2A (protein phosphatase 2 regulatory subunit Balpha). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 26.6), CNS E11.5 (RPKM 11.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 D1; 14 34.6 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (67251505..67309920, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (67014056..67072471, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24258 Neighboring gene BCL2/adenovirus E1B interacting protein 3-like Neighboring gene STARR-positive B cell enhancer mm9_chr14:67627653-67627954 Neighboring gene STARR-seq mESC enhancer starr_37004 Neighboring gene STARR-positive B cell enhancer ABC_E7328 Neighboring gene predicted gene, 52123 Neighboring gene predicted gene, 30438 Neighboring gene STARR-seq mESC enhancer starr_37007

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Regulatory Subunit PPP2R2A of PP2A Enhances Th1 and Th17 Differentiation through Activation of the GEF-H1/RhoA/ROCK Signaling Pathway. Pan W, et al. J Immunol, 2021 Apr 15. PMID 33762326, Free PMC Article
    2. B55α/PP2A Limits Endothelial Cell Apoptosis During Vascular Remodeling: A Complementary Approach To Disrupt Pathological Vessels? Ehling M, et al. Circ Res, 2020 Aug 28. PMID 32527198
    3. Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis. Yun S, et al. J Clin Invest, 2019 Aug 13. PMID 31408443, Free PMC Article
    4. The B55α subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation. Reid MA, et al. Mol Cell, 2013 Apr 25. PMID 23499005
    5. Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt. Kuo YC, et al. J Biol Chem, 2008 Jan 25. PMID 18042541

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. B55alpha/PP2A Limits Endothelial Cell Apoptosis During Vascular Remodeling: A Complementary Approach To Disrupt Pathological Vessels?
      Title: B55α/PP2A Limits Endothelial Cell Apoptosis During Vascular Remodeling: A Complementary Approach To Disrupt Pathological Vessels?
    2. Proteomics identified the PP2A regulatory subunit B55alpha as the factor recruiting PP2A to PDE4D5. The B55alpha-PP2A complex localized to adhesions and directly dephosphorylated PDE4D5.
      Title: Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis.
    3. Data suggest IGT10 mice, diabetes type 2 model, exhibit 2 genetic defects: haploinsufficiency (heterozygosity for null allele) of insulin receptor (Insr); splice-site mutation in protein phosphatase 2 regulatory subunit B alpha (Ppp2r2a). Inheritance of either allele results in insulin resistance but not overt diabetes. Double heterozygosity leads to insulin resistance and diabetes type 2 without increase in body weight.
      Title: Haploinsufficiency of the Insulin Receptor in the Presence of a Splice-Site Mutation in Ppp2r2a Results in a Novel Digenic Mouse Model of Type 2 Diabetes.
    4. Concurrent mTORC1 inactivation and PP2A-B55alpha stimulation fuel ULK1-dependent autophagy.
      Title: Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A.
    5. FBXL16 negatively regulates the activity of B55alpha-PP2A to modulate the genesis of FLK1+ progenitor cells.
      Title: F-box protein FBXL16 binds PP2A-B55α and regulates differentiation of embryonic stem cells along the FLK1+ lineage.
    6. Ppp2r2a is required for Connexin-43 dephosphorlyation during epidermal barrier acquisition
      Title: The protein phosphatase 2A regulatory subunit Ppp2r2a is required for Connexin-43 dephosphorlyation during epidermal barrier acquisition.
    7. The B55alpha-EDD-p53 pathway is essential for cancer cell survival and tumor growth under low glutamine conditions in vitro and in vivo.
      Title: The B55α subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation.
    8. PP-2A is less abundant than PP-1 in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed.
      Title: Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.
    9. that B55alpha-dependent targeting of the PP2A holoenzyme to Akt selectively regulates Akt phosphorylation at Thr-308 to regulate cell proliferation and survival.
      Title: Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tau protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to morphine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
    NP_001192117.1
    NP_001346962.1
    NP_001346963.1
    NP_082308.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205188.1 → NP_001192117.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 2

      See identical proteins and their annotated locations for NP_001192117.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC165148, AK010380, BC065100, CT030233
      Consensus CDS
      CCDS88697.1
      UniProtKB/TrEMBL
      Q3TPC5, Q9CWU3
      Related
      ENSMUSP00000153191.2, ENSMUST00000225380.2
      Conserved Domains (2) summary
      sd00039
      Location:31 → 79
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:29 → 327
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001360033.1 → NP_001346962.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 3

      Status: VALIDATED

      Source sequence(s)
      AA185461, AC165148, AK161507, BC065100, CT030233
      Conserved Domains (2) summary
      COG5170
      Location:2 → 283
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:21 → 57
      7WD40; WD40 repeat [structural motif]

    3. NM_001360034.1 → NP_001346963.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC165148, AK161507, BC065100, CT030233
      Conserved Domains (2) summary
      COG5170
      Location:2 → 283
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:21 → 57
      7WD40; WD40 repeat [structural motif]

    4. NM_028032.3 → NP_082308.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 1

      See identical proteins and their annotated locations for NP_082308.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC165148, AK161507, BC065100, CT030233
      Consensus CDS
      CCDS56967.1
      UniProtKB/Swiss-Prot
      Q6P1F6
      UniProtKB/TrEMBL
      Q3TPC5, Q3TT94
      Related
      ENSMUSP00000086640.6, ENSMUST00000089230.7
      Conserved Domains (2) summary
      COG5170
      Location:7 → 442
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:31 → 79
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      67251505..67309920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P1F6.1 GenPept UniProtKB/Swiss-Prot:Q6P1F6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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