Nnat neuronatin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nnatprovided by MGI
Official Full Name: neuronatinprovided by MGI
Primary source: MGI:MGI:104716
See related: Ensembl:ENSMUSG00000067786 AllianceGenome:MGI:104716
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Peg5; 5730414I02Rik
Summary: Acts upstream of or within positive regulation of insulin secretion and response to glucose. Located in cytoplasm. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; nervous system; and sensory organ. Orthologous to human NNAT (neuronatin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in whole brain E14.5 (RPKM 921.6), CNS E14 (RPKM 733.0) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 78.4 cM; 2 H1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (157401936..157404445)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (157560078..157562525)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNA methylation-mediated silencing of Neuronatin promotes hepatocellular carcinoma proliferation through the PI3K-Akt signaling pathway.
Title: DNA methylation-mediated silencing of Neuronatin promotes hepatocellular carcinoma proliferation through the PI3K-Akt signaling pathway.
Bisphenol A induces miR-708-5p through an ER stress-mediated mechanism altering neuronatin and neuropeptide Y expression in hypothalamic neuronal models.
Title: Bisphenol A induces miR-708-5p through an ER stress-mediated mechanism altering neuronatin and neuropeptide Y expression in hypothalamic neuronal models.
Neuronatin promotes SERCA uncoupling and its expression is altered in skeletal muscles of high-fat diet-fed mice.
Title: Neuronatin promotes SERCA uncoupling and its expression is altered in skeletal muscles of high-fat diet-fed mice.
Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity.
Title: Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity.
Nnat deletion was associated with postnatal growth restriction and adult obesity.
Title: Neuronatin deletion causes postnatal growth restriction and adult obesity in 129S2/Sv mice.
investigation of the function of Nnat in the adipose tissue; results indicate that NNAT plays an anti-inflammatory role in the adipose tissue
Title: Neuronatin Is Associated with an Anti-Inflammatory Role in the White Adipose Tissue.
The expression pattern suggests that Nnat may play an important role during eye development and in the maintenance of mature eye.
Title: Temporal and spatial expression pattern of Nnat during mouse eye development.
Nnat expression in hypothalamus is regulated by short-term nutrient availability, but unaltered by diet-induced obesity or calorie restriction.
Title: Differential pre-mRNA splicing regulates Nnat isoforms in the hypothalamus after gastric bypass surgery in mice.
Neuronatin appears to be a novel regulator of browning and metabolic substrate disposal in white adipocytes.
Title: Loss of neuronatin promotes "browning" of primary mouse adipocytes while reducing Glut1-mediated glucose disposal.
the Neuronatin locus employs the most basic mechanism for establishing allele-specific gene expression
Title: An intronic DNA sequence within the mouse Neuronatin gene exhibits biochemical characteristics of an ICR and acts as a transcriptional activator in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

AW107673 (e-PCR)
- UniSTS:178757

Nnat (e-PCR), detects polymorphism
- UniSTS:516451

BI286603 (e-PCR)
- UniSTS:245369

Nnat (e-PCR), detects polymorphism
- UniSTS:144031

Nnat (e-PCR), detects polymorphism
- UniSTS:144032

Nnat (e-PCR), detects polymorphism
- UniSTS:144033

Nnat (e-PCR), detects polymorphism
- UniSTS:144034

Nnat (e-PCR), detects polymorphism
- UniSTS:532149

Nnat (e-PCR), detects polymorphism
- UniSTS:532150

AA858569 (e-PCR)
- UniSTS:243412

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in brain development	IEA Inferred from Electronic Annotation more info
acts_upstream_of establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to glucose	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neuronatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291128.1 → NP_001278057.1 neuronatin isoform c

See identical proteins and their annotated locations for NP_001278057.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).

Source sequence(s)

AK160626, AL672259, BQ030646, BU705167, DN176829

Consensus CDS

CCDS71174.1

UniProtKB/TrEMBL

G3X9K1

Related

ENSMUSP00000085836.6, ENSMUST00000088484.6
NM_001291129.1 → NP_001278058.1 neuronatin isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate exon but contains a different in-frame exon in the central coding region, compared to variant 3. The encoded isoform (d) is shorter than isoform c.

Source sequence(s)

AK160626, AL672259, BQ030646, BU705167, DV062509

Consensus CDS

CCDS71175.1

UniProtKB/TrEMBL

G3UWR7

Related

ENSMUSP00000133397.2, ENSMUST00000173595.2
NM_001291130.1 → NP_001278059.1 neuronatin isoform e

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an alternate exon but contains a different exon that results in a frameshift in the 3' coding region, compared to variant 3. The encoded isoform (e) has a distinct C-terminus and is shorter than isoform c.

Source sequence(s)

AK160626, AL672259, BQ030646, BU705167

Consensus CDS

CCDS79857.1

UniProtKB/TrEMBL

G3UWR4

Related

ENSMUSP00000133394.2, ENSMUST00000173839.2
NM_010923.3 → NP_035053.1 neuronatin isoform alpha

See identical proteins and their annotated locations for NP_035053.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks an alternate exon but contains a different exon that results in a frameshift in the 3' coding region, compared to variant 3. The encoded isoform (alpha, also known as Neuronatin-3) has a distinct C-terminus and is shorter than isoform c.

Source sequence(s)

AK160626, AL672259, BQ030646, BU705167

Consensus CDS

CCDS38306.1

UniProtKB/Swiss-Prot

Q548Q0, Q61979, Q61980, Q61981

Related

ENSMUSP00000105152.2, ENSMUST00000109526.2
NM_180960.3 → NP_851291.1 neuronatin isoform beta

See identical proteins and their annotated locations for NP_851291.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 3. The encoded isoform (beta, also known as Neuronatin-2) has a distinct C-terminus and is shorter than isoform c.

Source sequence(s)

AK160626, AL672259, AU079843, BQ030646, BU705167

Consensus CDS

CCDS38307.1

UniProtKB/TrEMBL

Q548P9

Related

ENSMUSP00000129821.2, ENSMUST00000153739.9