Ltbr lymphotoxin B receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ltbrprovided by MGI
Official Full Name: lymphotoxin B receptorprovided by MGI
Primary source: MGI:MGI:104875
See related: Ensembl:ENSMUSG00000030339 AllianceGenome:MGI:104875
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ltar; TNFCR; Tnfbr; TNFRrp; LTbetaR; TNFR-RP; Tnfrsf3; TNFR2-RP; TNF-R-III
Summary: Predicted to enable identical protein binding activity and ubiquitin protein ligase binding activity. Acts upstream of or within myeloid dendritic cell differentiation. Predicted to be located in Golgi apparatus. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and long bone. Orthologous to human LTBR (lymphotoxin beta receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in duodenum adult (RPKM 103.9), adrenal adult (RPKM 86.6) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 59.32 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (125283534..125291026, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (125306571..125313885, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CREB1 Transcriptionally Activates LTBR to Promote the NF-kappaB Pathway and Apoptosis in Lung Epithelial Cells.
Title: CREB1 Transcriptionally Activates LTBR to Promote the NF-κB Pathway and Apoptosis in Lung Epithelial Cells.
LTbetaR overexpression promotes plasma cell accumulation.
Title: LTβR overexpression promotes plasma cell accumulation.
The transcription factor Sox4 is required for thymic tuft cell development.
Title: The transcription factor Sox4 is required for thymic tuft cell development.
Redefining the Role of Lymphotoxin Beta Receptor in the Maintenance of Lymphoid Organs and Immune Cell Homeostasis in Adulthood.
Title: Redefining the Role of Lymphotoxin Beta Receptor in the Maintenance of Lymphoid Organs and Immune Cell Homeostasis in Adulthood.
Type 3 Innate Lymphoid Cells Direct Goblet Cell Differentiation via the LT-LTbetaR Pathway during Listeria Infection.
Title: Type 3 Innate Lymphoid Cells Direct Goblet Cell Differentiation via the LT-LTβR Pathway during Listeria Infection.
LIGHT/LTbetaR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells.
Title: LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells.
Inhibition of LTbetaR signalling activates WNT-induced regeneration in lung.
Title: Inhibition of LTβR signalling activates WNT-induced regeneration in lung.
Langerhans cells activate lymphatic endothelial cells via the LIGHT-LTbetaR signaling axis to promote DC migration or tumor cell metastasis.
Title: Langerhans Cells Control Lymphatic Vessel Function during Inflammation via LIGHT-LTβR Signaling.
LIGHT signaling through lymphotoxin beta receptor plays a critical role in the progression of experimental colitis
Title: The Tumor Necrosis Factor Superfamily Members TNFSF14 (LIGHT), Lymphotoxin β and Lymphotoxin β Receptor Interact to Regulate Intestinal Inflammation.
a role for LTbetaR in the initiation of thymus emigration that segregates from its control of medulla organization.
Title: Endothelial cells act as gatekeepers for LTβR-dependent thymocyte emigration.

Submit: New GeneRIF Correction See all GeneRIFs (88)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (4)
Endonuclease-mediated (5) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI256028 (e-PCR)
- UniSTS:179464

U29173 (e-PCR)
- UniSTS:125715

D6Mit134 (e-PCR), detects polymorphism
- UniSTS:130678

Ltbr (e-PCR), detects polymorphism
- UniSTS:275859

Ltbr (e-PCR), detects polymorphism
- UniSTS:143799

Ltbr (e-PCR), detects polymorphism
- UniSTS:143800

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in hematopoietic or lymphoid organ development	IEA Inferred from Electronic Annotation more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lymph node development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within myeloid dendritic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 3

Names: LT-beta receptor; TNF receptor-related protein; lymphotoxin-beta receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010736.5 → NP_034866.1 tumor necrosis factor receptor superfamily member 3 precursor

See identical proteins and their annotated locations for NP_034866.1

Status: VALIDATED

Source sequence(s)

AC140324

Consensus CDS

CCDS20549.1

UniProtKB/Swiss-Prot

P50284

UniProtKB/TrEMBL

B2RRV3, Q3UK82

Related

ENSMUSP00000032489.8, ENSMUST00000032489.8

Conserved Domains (3) summary

cd00185
Location:172 → 212

TNFRSF; CRD2 [structural motif]

cd10578
Location:11 → 170

TNFRSF3; Tumor necrosis factor receptor superfamily member 3 (TNFRSF3), also known as lymphotoxin beta receptor (LTBR)

cl22855
Location:148 → 212

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

125283534..125291026 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165897.1 → XP_036021790.1 tumor necrosis factor receptor superfamily member 3 isoform X1

Conserved Domains (3) summary

cd00185
Location:172 → 212

TNFRSF; CRD2 [structural motif]

cd10578
Location:11 → 170

TNFRSF3; Tumor necrosis factor receptor superfamily member 3 (TNFRSF3), also known as lymphotoxin beta receptor (LTBR)

cl22855
Location:148 → 212

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)