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    Lmcd1 LIM and cysteine-rich domains 1 [ Mus musculus (house mouse) ]

    Gene ID: 30937, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Lmcd1provided by MGI
    Official Full Name
    LIM and cysteine-rich domains 1provided by MGI
    Primary source
    MGI:MGI:1353635
    See related
    Ensembl:ENSMUSG00000057604 AllianceGenome:MGI:1353635
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    dyxin
    Summary
    Enables transcription corepressor activity. Involved in positive regulation of calcineurin-NFAT signaling cascade and regulation of cardiac muscle hypertrophy. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and lung. Orthologous to human LMCD1 (LIM and cysteine rich domains 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bladder adult (RPKM 56.8), heart adult (RPKM 8.8) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 E3; 6 52.14 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (112250747..112307384)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (112273758..112330423)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16998 Neighboring gene predicted gene 20387 Neighboring gene STARR-seq mESC enhancer starr_16999 Neighboring gene glutamate receptor, metabotropic 7 Neighboring gene STARR-seq mESC enhancer starr_17000 Neighboring gene STARR-seq mESC enhancer starr_17001 Neighboring gene STARR-seq mESC enhancer starr_17002 Neighboring gene STARR-seq mESC enhancer starr_17005 Neighboring gene STARR-seq mESC enhancer starr_17006 Neighboring gene STARR-seq mESC enhancer starr_17008 Neighboring gene STARR-seq mESC enhancer starr_17009 Neighboring gene STARR-seq mESC enhancer starr_17010 Neighboring gene RIKEN cDNA 1700054K19 gene Neighboring gene STARR-seq mESC enhancer starr_17012 Neighboring gene STARR-seq mESC enhancer starr_17013 Neighboring gene STARR-seq mESC enhancer starr_17014 Neighboring gene RIKEN cDNA 5031434C07 gene Neighboring gene STARR-seq mESC enhancer starr_17015 Neighboring gene predicted gene, 38873 Neighboring gene 60S ribosomal protein L23a pseudogene Neighboring gene ssu-2 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Suppression of LMCD1 ameliorates renal fibrosis by blocking the activation of ERK pathway. Yu R, et al. Biochim Biophys Acta Mol Cell Res, 2022 Apr. PMID 34968577
    2. Lmcd1/Dyxin, a novel Z-disc associated LIM protein, mediates cardiac hypertrophy in vitro and in vivo. Frank D, et al. J Mol Cell Cardiol, 2010 Oct. PMID 20600098
    3. LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force. Ferreira DMS, et al. Skelet Muscle, 2019 Oct 31. PMID 31666122, Free PMC Article
    4. Testicular Lmcd1 regulates phagocytosis by Sertoli cells through modulation of NFAT1/Txlna signaling pathway. Jin X, et al. Aging Cell, 2020 Oct. PMID 32840323, Free PMC Article
    5. Myristoylation of LMCD1 Leads to Its Species-Specific Derepression of E2F1 and NFATc1 in the Modulation of CDC6 and IL-33 Expression During Development of Vascular Lesions. Govatati S, et al. Arterioscler Thromb Vasc Biol, 2020 May. PMID 32160773, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LMCD1 is involved in tubulointerstitial inflammation in the early phase of renal fibrosis by promoting NFATc1-mediated NLRP3 activation.
      Title: LMCD1 is involved in tubulointerstitial inflammation in the early phase of renal fibrosis by promoting NFATc1-mediated NLRP3 activation.
    2. Suppression of LMCD1 ameliorates renal fibrosis by blocking the activation of ERK pathway.
      Title: Suppression of LMCD1 ameliorates renal fibrosis by blocking the activation of ERK pathway.
    3. Testicular Lmcd1 regulates phagocytosis by Sertoli cells through modulation of NFAT1/Txlna signaling pathway.
      Title: Testicular Lmcd1 regulates phagocytosis by Sertoli cells through modulation of NFAT1/Txlna signaling pathway.
    4. LMCD1 acts as a repressor of NFATc1 in humans in mice in the induction of CDC6 and IL-33 expression during development of vascular lesions.
      Title: Myristoylation of LMCD1 Leads to Its Species-Specific Derepression of E2F1 and NFATc1 in the Modulation of CDC6 and IL-33 Expression During Development of Vascular Lesions.
    5. Gain- and loss-of-function studies show that LMCD1 controls protein synthesis, muscle fiber size, specific force, Ca(2+) handling, and fatigue resistance.
      Title: LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force.
    6. Study show that the novel LIM protein Lmcd1/Dyxin is both sufficient and necessary for cardiomyocyte hypertrophy.
      Title: Lmcd1/Dyxin, a novel Z-disc associated LIM protein, mediates cardiac hypertrophy in vitro and in vivo.
    7. Expression of LMCD1/dyxin is remarkably similar to that of GATA6, with high-level expression observed in distal airway epithelium of the lung, vascular smooth muscle, and myocardium.
      Title: LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC29184

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of calcineurin-NFAT signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cardiac muscle hypertrophy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LIM and cysteine-rich domains protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144799.3 → NP_659048.1  LIM and cysteine-rich domains protein 1

      See identical proteins and their annotated locations for NP_659048.1

      Status: VALIDATED

      Source sequence(s)
      AC153822
      Consensus CDS
      CCDS20403.1
      UniProtKB/Swiss-Prot
      Q8VEE1
      UniProtKB/TrEMBL
      Q3TVW6
      Related
      ENSMUSP00000032376.6, ENSMUST00000032376.6
      Conserved Domains (3) summary
      cd09340
      Location:243 → 300
      LIM1_Testin_like; The first LIM domain of Testin-like family
      cd09829
      Location:116 → 203
      PET_testin; The PET domain of Testin
      cl02475
      Location:306 → 359
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      112250747..112307384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166210.1 → XP_036022103.1  LIM and cysteine-rich domains protein 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VEE1.1 GenPept UniProtKB/Swiss-Prot:Q8VEE1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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