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    Zfp472 zinc finger protein 472 [ Mus musculus (house mouse) ]

    Gene ID: 224691, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp472provided by MGI
    Official Full Name
    zinc finger protein 472provided by MGI
    Primary source
    MGI:MGI:2385049
    See related
    Ensembl:ENSMUSG00000053600 AllianceGenome:MGI:2385049
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Krim1; KRIM-1; Krim-1A; Krim-1B
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus and genitourinary system. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 2.4), bladder adult (RPKM 2.2) and 23 other tissues See more
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    Genomic context

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    Location:
    17 B1; 17 17.98 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (33184805..33198185)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (32965831..32979211)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 13 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:33084248-33084483 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 41 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7516 Neighboring gene zinc finger protein 952 Neighboring gene zinc finger protein 763 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:33170086-33170195 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:33170311-33170494

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of a novel KRAB/C2H2 zinc finger protein Mipu1. Jiang L, et al. Biochem Biophys Res Commun, 2007 May 18. PMID 17397802
    2. Identification of a novel Krüppel-associated box domain protein, Krim-1, that interacts with c-Myc and inhibits its oncogenic activity. Hennemann H, et al. J Biol Chem, 2003 Aug 1. PMID 12748187
    3. A functional screen to identify novel effectors of hematopoietic stem cell activity. Deneault E, et al. Cell, 2009 Apr 17. PMID 19379700, Free PMC Article
    4. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
    5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 472
    Names
    KRAB box containing zinc finger protein
    Krab box proteins interacting with myc 1
    zin finger protein 472

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153063.3 → NP_694703.2  zinc finger protein 472

      Status: VALIDATED

      Source sequence(s)
      AK142395, BB652931, BQ885210
      Consensus CDS
      CCDS50062.1
      UniProtKB/TrEMBL
      B0V2W5
      Related
      ENSMUSP00000036514.8, ENSMUST00000039132.9
      Conserved Domains (5) summary
      smart00349
      Location:10 → 50
      KRAB; krueppel associated box
      COG5048
      Location:195 → 492
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:395 → 415
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:10 → 49
      KRAB; KRAB box
      pfam13465
      Location:435 → 460
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      33184805..33198185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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