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    Stambpl1 STAM binding protein like 1 [ Mus musculus (house mouse) ]

    Gene ID: 76630, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Stambpl1provided by MGI
    Official Full Name
    STAM binding protein like 1provided by MGI
    Primary source
    MGI:MGI:1923880
    See related
    Ensembl:ENSMUSG00000024776 AllianceGenome:MGI:1923880
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AMSH-FP; ALMalpha; 1700095N21Rik; 8230401J17Rik
    Summary
    Predicted to enable Lys63-specific deubiquitinase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein K63-linked deubiquitination. Predicted to act upstream of or within proteolysis. Predicted to be active in endosome and membrane. Is expressed in alimentary system; central nervous system; dorsal root ganglion; and limb. Orthologous to human STAMBPL1 (STAM binding protein like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 6.7), thymus adult (RPKM 5.8) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 C1; 19 29.35 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (34169629..34217733)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (34190378..34240333)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene lipase, family member N Neighboring gene STARR-seq mESC enhancer starr_45988 Neighboring gene STARR-seq mESC enhancer starr_45989 Neighboring gene lipase, family member M Neighboring gene ankyrin repeat domain 22 Neighboring gene STARR-seq mESC enhancer starr_45990 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:34255778-34255996 Neighboring gene STARR-positive B cell enhancer ABC_E5696 Neighboring gene STARR-seq mESC enhancer starr_45992 Neighboring gene actin alpha 2, smooth muscle, aorta Neighboring gene predicted gene, 31355

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A newly identified AMSH-family protein is specifically expressed in haploid stages of testicular germ cells. Kitajima K, et al. Biochem Biophys Res Commun, 2003 Sep 12. PMID 12943674
    2. A novel transcript encoding truncated LIM kinase 2 is specifically expressed in male germ cells undergoing meiosis. Takahashi H, et al. Biochem Biophys Res Commun, 1998 Aug 10. PMID 9705845
    3. An RNA interference screen identifies the Deubiquitinase STAMBPL1 as a critical regulator of human T-cell leukemia virus type 1 tax nuclear export and NF-κB activation. Lavorgna A, et al. J Virol, 2012 Mar. PMID 22258247, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AMSH-FP is specifically expressed in haploid stages of testicular germ cells and has a functional role in spermiogenesis [AMSH-FP]
      Title: A newly identified AMSH-family protein is specifically expressed in haploid stages of testicular germ cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K63-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K63-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal-dependent deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to L-leucine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    AMSH-like protease
    Names
    AMSH-LP
    AMSH-family protein
    NP_001347645.1
    NP_001347646.1
    NP_001347647.1
    NP_001347648.1
    NP_001347649.1
    NP_083958.3
    XP_006527514.1
    XP_006527515.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360716.1 → NP_001347645.1  AMSH-like protease isoform 1

      Status: VALIDATED

      Source sequence(s)
      AB010121, AC102285, AC165239, AK138126
      Consensus CDS
      CCDS29756.1
      UniProtKB/Swiss-Prot
      Q76LY0, Q76N33, Q8VEK5
      Related
      ENSMUSP00000159218.2, ENSMUST00000239240.2
      Conserved Domains (3) summary
      cd08066
      Location:266 → 436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      COG0544
      Location:119 → 195
      Tig; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]
      pfam08969
      Location:28 → 129
      USP8_dimer; USP8 dimerization domain

    2. NM_001360717.1 → NP_001347646.1  AMSH-like protease isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102285, AC165239
      Consensus CDS
      CCDS29756.1
      UniProtKB/Swiss-Prot
      Q76LY0, Q76N33, Q8VEK5
      Conserved Domains (3) summary
      cd08066
      Location:266 → 436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      COG0544
      Location:119 → 195
      Tig; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]
      pfam08969
      Location:28 → 129
      USP8_dimer; USP8 dimerization domain

    3. NM_001360718.1 → NP_001347647.1  AMSH-like protease isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102285, AC165239
      Consensus CDS
      CCDS29756.1
      UniProtKB/Swiss-Prot
      Q76LY0, Q76N33, Q8VEK5
      Conserved Domains (3) summary
      cd08066
      Location:266 → 436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      COG0544
      Location:119 → 195
      Tig; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]
      pfam08969
      Location:28 → 129
      USP8_dimer; USP8 dimerization domain

    4. NM_001360719.1 → NP_001347648.1  AMSH-like protease isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102285
      Consensus CDS
      CCDS29756.1
      UniProtKB/Swiss-Prot
      Q76LY0, Q76N33, Q8VEK5
      Related
      ENSMUSP00000112938.2, ENSMUST00000119603.2
      Conserved Domains (3) summary
      cd08066
      Location:266 → 436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      COG0544
      Location:119 → 195
      Tig; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]
      pfam08969
      Location:28 → 129
      USP8_dimer; USP8 dimerization domain

    5. NM_001360720.1 → NP_001347649.1  AMSH-like protease isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102285, AK007087
      Conserved Domains (1) summary
      cd08066
      Location:100 → 270
      MPN_AMSH_like; Mov34/MPN/PAD-1 family

    6. NM_029682.5 → NP_083958.3  AMSH-like protease isoform 1

      See identical proteins and their annotated locations for NP_083958.3

      Status: VALIDATED

      Source sequence(s)
      AB010121, AC102285, AC165239
      Consensus CDS
      CCDS29756.1
      UniProtKB/Swiss-Prot
      Q76LY0, Q76N33, Q8VEK5
      Related
      ENSMUSP00000059927.9, ENSMUST00000054956.15
      Conserved Domains (3) summary
      cd08066
      Location:266 → 436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      COG0544
      Location:119 → 195
      Tig; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]
      pfam08969
      Location:28 → 129
      USP8_dimer; USP8 dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      34169629..34217733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527452.5 → XP_006527515.1  AMSH-like protease isoform X1

      See identical proteins and their annotated locations for XP_006527515.1

      UniProtKB/Swiss-Prot
      Q76LY0, Q76N33, Q8VEK5
      Conserved Domains (3) summary
      cd08066
      Location:266 → 436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      COG0544
      Location:119 → 195
      Tig; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]
      pfam08969
      Location:28 → 129
      USP8_dimer; USP8 dimerization domain

    2. XM_006527451.5 → XP_006527514.1  AMSH-like protease isoform X1

      See identical proteins and their annotated locations for XP_006527514.1

      UniProtKB/Swiss-Prot
      Q76LY0, Q76N33, Q8VEK5
      Conserved Domains (3) summary
      cd08066
      Location:266 → 436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      COG0544
      Location:119 → 195
      Tig; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]
      pfam08969
      Location:28 → 129
      USP8_dimer; USP8 dimerization domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q76N33.1 GenPept UniProtKB/Swiss-Prot:Q76N33

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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