Tnfrsf21 tumor necrosis factor receptor superfamily, member 21 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnfrsf21provided by MGI
Official Full Name: tumor necrosis factor receptor superfamily, member 21provided by MGI
Primary source: MGI:MGI:2151075
See related: Ensembl:ENSMUSG00000023915 AllianceGenome:MGI:2151075
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DR6; TR7
Summary: Involved in several processes, including negative regulation of cytokine production; negative regulation of lymphocyte proliferation; and oligodendrocyte apoptotic process. Located in axon. Is intrinsic component of plasma membrane. Is expressed in several structures, including alimentary system; lung; metanephros; nervous system; and nose. Orthologous to human TNFRSF21 (TNF receptor superfamily member 21). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney adult (RPKM 73.1), stomach adult (RPKM 48.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B3; 17 19.69 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (43327446..43400079)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (43016555..43089188)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endothelial DR6 in blood-brain barrier malfunction in Alzheimer's disease.
Title: Endothelial DR6 in blood-brain barrier malfunction in Alzheimer's disease.
The metabolite alpha-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8.
Title: The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8.
DR6 drives catastrophic degeneration in axons demarcated by spheroid rupture.
Title: p75NTR and DR6 Regulate Distinct Phases of Axon Degeneration Demarcated by Spheroid Rupture.
DR6 contributes to autoimmunity in lupus-prone mice.
Title: Death receptor 6 contributes to autoimmunity in lupus-prone mice.
An orphan receptor, death receptor 6 (DR6), is required to drive Wallerian axon degeneration after axotomy in sympathetic and sensory neurons cultured in microfluidic devices.
Title: Death Receptor 6 Promotes Wallerian Degeneration in Peripheral Axons.
miR-17-5p induction was verified during renal ischemia-reperfusion injury. The induction was mediated by p53 and, following induction, this microRNA may repress death receptor 6 (DR6) to protect kidney cells and tissues from injury.
Title: Induction of microRNA-17-5p by p53 protects against renal ischemia-reperfusion injury by targeting death receptor 6.
data identify a new mechanism underlying tumour cell extravasation and metastasis, and suggest endothelial DR6-mediated necroptotic signalling pathways as targets for anti-metastatic therapies
Title: Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis.
This study demonistrated that DR6 to contribute to axonal pruning occurring during experience-dependent cortical plasticity throughout life.
Title: Death receptor 6 regulates adult experience-dependent cortical plasticity.
A DR6/p75(NTR) complex is responsible for beta-amyloid-induced cortical neuron death.
Title: A DR6/p75(NTR) complex is responsible for β-amyloid-induced cortical neuron death.
Pla2g7 and Tnfrsf21 have been identified as genetic susceptibility to influenza genes in mice.
Title: Mapping of clinical and expression quantitative trait loci in a sex-dependent effect of host susceptibility to mouse-adapted influenza H3N2/HK/1/68.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (5) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125109 (e-PCR)
- UniSTS:161931

AA959878 (e-PCR)
- UniSTS:160661

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in B cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in axonal fasciculation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in humoral immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in humoral immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of B cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-13 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-5 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of myelination	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligodendrocyte apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligodendrocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 21

Names: Death receptor 6; TNFR-related death receptor-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178589.3 → NP_848704.1 tumor necrosis factor receptor superfamily member 21 precursor

See identical proteins and their annotated locations for NP_848704.1

Status: PROVISIONAL

Source sequence(s)

AK043823

Consensus CDS

CCDS28794.1

UniProtKB/Swiss-Prot

Q3UYG3, Q543Y9, Q91W77, Q91XH9, Q9EPU5

UniProtKB/TrEMBL

Q8BZU6

Related

ENSMUSP00000024708.5, ENSMUST00000024708.6

Conserved Domains (3) summary

cd08778
Location:414 → 497

Death_TNFRSF21; Death domain of tumor necrosis factor receptor superfamily member 21

cd10583
Location:53 → 211

TNFRSF21; Tumor necrosis factor receptor superfamily member 21 (TNFRSF21), also known as death receptor (DR6)

cl14633
Location:594 → 654

DD; Death Domain Superfamily of protein-protein interaction domains