Cyb5rl cytochrome b5 reductase-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyb5rlprovided by MGI
Official Full Name: cytochrome b5 reductase-likeprovided by MGI
Primary source: MGI:MGI:1919657
See related: Ensembl:ENSMUSG00000028621 AllianceGenome:MGI:1919657
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2810410C14Rik
Summary: Predicted to enable cytochrome-b5 reductase activity, acting on NAD(P)H. Predicted to be located in nucleoplasm. Is expressed in cranial ganglion; dorsal root ganglion; and trigeminal nerve. Orthologous to human CYB5RL (cytochrome b5 reductase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 3.0), kidney adult (RPKM 2.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C7; 4 49.99 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (106924035..106945204)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (107066830..107088007)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234983

NoName (e-PCR)
- UniSTS:234984

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytochrome-b5 reductase activity, acting on NAD(P)H	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NADH-cytochrome b5 reductase-like

NP_001333481.1

EC 1.6.2.2

NP_001364012.1

EC 1.6.2.2

NP_001364013.1

EC 1.6.2.2

NP_001364014.1

EC 1.6.2.2

NP_001364015.1

EC 1.6.2.2

NP_001364016.1

EC 1.6.2.2

NP_001364017.1

EC 1.6.2.2

NP_780680.1

EC 1.6.2.2

XP_006503009.1

EC 1.6.2.2

XP_006503010.1

EC 1.6.2.2

XP_006503011.1

EC 1.6.2.2

XP_006503013.1

EC 1.6.2.2

XP_006503014.1

EC 1.6.2.2

XP_006503015.1

EC 1.6.2.2

XP_006503017.1

EC 1.6.2.2

XP_006503018.1

EC 1.6.2.2

XP_006503020.1

EC 1.6.2.2

XP_006503022.1

EC 1.6.2.2

XP_006503025.1

EC 1.6.2.2

XP_011238784.1

EC 1.6.2.2

XP_011238786.1

EC 1.6.2.2

XP_017175622.1

EC 1.6.2.2

XP_030109289.1

EC 1.6.2.2

XP_036019906.1

EC 1.6.2.2

XP_036019907.1

EC 1.6.2.2

XP_036019908.1

EC 1.6.2.2

XP_036019909.1

EC 1.6.2.2

XP_036019910.1

EC 1.6.2.2

XP_036019911.1

EC 1.6.2.2

XP_036019912.1

EC 1.6.2.2

XP_036019913.1

EC 1.6.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001346552.2 → NP_001333481.1 NADH-cytochrome b5 reductase-like isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 3, and 4 all encode the same isoform (1).

Source sequence(s)

AL607132

Consensus CDS

CCDS84765.1

UniProtKB/Swiss-Prot

B1AS41, B1AS42, Q571N5, Q80W48, Q99KB7

Related

ENSMUSP00000102369.2, ENSMUST00000106758.8

Conserved Domains (2) summary

cd06183
Location:83 → 316

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:13 → 52

Oxidored-like; Oxidoreductase-like protein, N-terminal
NM_001377083.1 → NP_001364012.1 NADH-cytochrome b5 reductase-like isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (3), as well as variants 1 and 4, encodes isoform 1.

Source sequence(s)

AL607132

UniProtKB/Swiss-Prot

B1AS41, B1AS42, Q571N5, Q80W48, Q99KB7

Conserved Domains (2) summary

cd06183
Location:83 → 316

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:13 → 52

Oxidored-like; Oxidoreductase-like protein, N-terminal
NM_001377084.1 → NP_001364013.1 NADH-cytochrome b5 reductase-like isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (4), as well as variants 1 and 3, encodes isoform 1.

Source sequence(s)

AL607132

UniProtKB/Swiss-Prot

B1AS41, B1AS42, Q571N5, Q80W48, Q99KB7

Conserved Domains (2) summary

cd06183
Location:83 → 316

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:13 → 52

Oxidored-like; Oxidoreductase-like protein, N-terminal
NM_001377085.1 → NP_001364014.1 NADH-cytochrome b5 reductase-like isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (5), as well as variant 6, encodes isoform 3.

Source sequence(s)

AL607132

Conserved Domains (2) summary

cd06183
Location:83 → 249

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:13 → 52

Oxidored-like; Oxidoreductase-like protein, N-terminal
NM_001377086.1 → NP_001364015.1 NADH-cytochrome b5 reductase-like isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (6), as well as variant 5, encodes isoform 3.

Source sequence(s)

AL607132

Conserved Domains (2) summary

cd06183
Location:83 → 249

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:13 → 52

Oxidored-like; Oxidoreductase-like protein, N-terminal
NM_001377087.1 → NP_001364016.1 NADH-cytochrome b5 reductase-like isoform 4

Status: VALIDATED

Source sequence(s)

AL607132

Conserved Domains (2) summary

cd06183
Location:83 → 249

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:13 → 52

Oxidored-like; Oxidoreductase-like protein, N-terminal
NM_001377088.1 → NP_001364017.1 NADH-cytochrome b5 reductase-like isoform 5

Status: VALIDATED

Source sequence(s)

AL607132

Conserved Domains (2) summary

cd06183
Location:83 → 264

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:13 → 52

Oxidored-like; Oxidoreductase-like protein, N-terminal
NM_175471.4 → NP_780680.1 NADH-cytochrome b5 reductase-like isoform 2

See identical proteins and their annotated locations for NP_780680.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AL607132

Consensus CDS

CCDS38829.1

UniProtKB/Swiss-Prot

B1AS42

Related

ENSMUSP00000102367.3, ENSMUST00000106756.9

Conserved Domains (1) summary

cd06183
Location:23 → 256

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

106924035..106945204

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011240482.4 → XP_011238784.1 NADH-cytochrome b5 reductase-like isoform X7

Conserved Domains (2) summary

cd06183
Location:147 → 355

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:77 → 116

Oxidored-like; Oxidoreductase-like protein, N-terminal
XM_030253429.2 → XP_030109289.1 NADH-cytochrome b5 reductase-like isoform X10

Conserved Domains (2) summary

cd06183
Location:147 → 313

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:77 → 116

Oxidored-like; Oxidoreductase-like protein, N-terminal
XM_036164016.1 → XP_036019909.1 NADH-cytochrome b5 reductase-like isoform X16

Conserved Domains (2) summary

cd06183
Location:147 → 278

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:77 → 116

Oxidored-like; Oxidoreductase-like protein, N-terminal
XM_017320133.3 → XP_017175622.1 NADH-cytochrome b5 reductase-like isoform X20

Conserved Domains (2) summary

pfam09791
Location:77 → 116

Oxidored-like; Oxidoreductase-like protein, N-terminal

cl06868
Location:147 → 211

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
XM_006502946.5 → XP_006503009.1 NADH-cytochrome b5 reductase-like isoform X1

Conserved Domains (2) summary

cd06183
Location:147 → 355

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:77 → 116

Oxidored-like; Oxidoreductase-like protein, N-terminal
XM_006502947.5 → XP_006503010.1 NADH-cytochrome b5 reductase-like isoform X2

Conserved Domains (2) summary

cd06183
Location:147 → 422

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:77 → 116

Oxidored-like; Oxidoreductase-like protein, N-terminal
XM_006502950.5 → XP_006503013.1 NADH-cytochrome b5 reductase-like isoform X4

Conserved Domains (2) summary

cd06183
Location:147 → 313

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:77 → 116

Oxidored-like; Oxidoreductase-like protein, N-terminal
XM_006502954.5 → XP_006503017.1 NADH-cytochrome b5 reductase-like isoform X6

Conserved Domains (2) summary

cd06183
Location:147 → 278

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:77 → 116

Oxidored-like; Oxidoreductase-like protein, N-terminal
XM_006502955.4 → XP_006503018.1 NADH-cytochrome b5 reductase-like isoform X8

Conserved Domains (2) summary

cd06183
Location:147 → 345

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:77 → 116

Oxidored-like; Oxidoreductase-like protein, N-terminal
XM_006502948.5 → XP_006503011.1 NADH-cytochrome b5 reductase-like isoform X3

Conserved Domains (2) summary

cd06183
Location:123 → 331

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:53 → 92

Oxidored-like; Oxidoreductase-like protein, N-terminal
XM_036164013.1 → XP_036019906.1 NADH-cytochrome b5 reductase-like isoform X9

Conserved Domains (2) summary

cd06183
Location:123 → 254

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:53 → 92

Oxidored-like; Oxidoreductase-like protein, N-terminal
XM_036164014.1 → XP_036019907.1 NADH-cytochrome b5 reductase-like isoform X12

Conserved Domains (2) summary

cd06183
Location:123 → 321

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:53 → 92

Oxidored-like; Oxidoreductase-like protein, N-terminal
XM_036164018.1 → XP_036019911.1 NADH-cytochrome b5 reductase-like isoform X18

Conserved Domains (2) summary

cd06183
Location:147 → 244

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:77 → 116

Oxidored-like; Oxidoreductase-like protein, N-terminal
XM_036164019.1 → XP_036019912.1 NADH-cytochrome b5 reductase-like isoform X19

Conserved Domains (2) summary

cd06183
Location:123 → 220

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:53 → 92

Oxidored-like; Oxidoreductase-like protein, N-terminal
XM_006502957.5 → XP_006503020.1 NADH-cytochrome b5 reductase-like isoform X11

Conserved Domains (2) summary

pfam09791
Location:77 → 116

Oxidored-like; Oxidoreductase-like protein, N-terminal

cl06868
Location:147 → 210

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
XM_006502952.5 → XP_006503015.1 NADH-cytochrome b5 reductase-like isoform X5

See identical proteins and their annotated locations for XP_006503015.1

Conserved Domains (2) summary

cd06183
Location:83 → 291

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:13 → 52

Oxidored-like; Oxidoreductase-like protein, N-terminal
XM_036164015.1 → XP_036019908.1 NADH-cytochrome b5 reductase-like isoform X14

UniProtKB/Swiss-Prot

B1AS41, B1AS42, Q571N5, Q80W48, Q99KB7

Conserved Domains (2) summary

cd06183
Location:83 → 316

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:13 → 52

Oxidored-like; Oxidoreductase-like protein, N-terminal
XM_036164020.1 → XP_036019913.1 NADH-cytochrome b5 reductase-like isoform X21

Conserved Domains (1) summary

cd06183
Location:23 → 189

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
XM_006502959.4 → XP_006503022.1 NADH-cytochrome b5 reductase-like isoform X13

See identical proteins and their annotated locations for XP_006503022.1

Conserved Domains (1) summary

cd06183
Location:23 → 231

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
XM_006502951.4 → XP_006503014.1 NADH-cytochrome b5 reductase-like isoform X5

See identical proteins and their annotated locations for XP_006503014.1

Conserved Domains (2) summary

cd06183
Location:83 → 291

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:13 → 52

Oxidored-like; Oxidoreductase-like protein, N-terminal
XM_036164017.1 → XP_036019910.1 NADH-cytochrome b5 reductase-like isoform X17

Related

ENSMUSP00000030364.7, ENSMUST00000030364.13

Conserved Domains (2) summary

cd06183
Location:83 → 281

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

pfam09791
Location:13 → 52

Oxidored-like; Oxidoreductase-like protein, N-terminal
XM_006502962.5 → XP_006503025.1 NADH-cytochrome b5 reductase-like isoform X15

See identical proteins and their annotated locations for XP_006503025.1

Conserved Domains (1) summary

cd06183
Location:2 → 206

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
XM_011240484.4 → XP_011238786.1 NADH-cytochrome b5 reductase-like isoform X15

See identical proteins and their annotated locations for XP_011238786.1

Conserved Domains (1) summary

cd06183
Location:2 → 206

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...