Trip4 thyroid hormone receptor interactor 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trip4provided by MGI
Official Full Name: thyroid hormone receptor interactor 4provided by MGI
Primary source: MGI:MGI:1928469
See related: Ensembl:ENSMUSG00000032386 AllianceGenome:MGI:1928469
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Asc1; ASC-1; 4930558E03Rik
Summary: Predicted to enable enzyme binding activity; estrogen receptor binding activity; and transcription coactivator activity. Involved in regulation of myoblast differentiation. Acts upstream of or within toxin transport. Predicted to be located in cytoplasm; neuromuscular junction; and nuclear body. Predicted to be part of activating signal cointegrator 1 complex. Predicted to be active in nucleus. Predicted to colocalize with centrosome. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; retina nuclear layer; and skin. Orthologous to human TRIP4 (thyroid hormone receptor interactor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 5.1), testis adult (RPKM 4.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 C; 9 35.55 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (65736208..65816150, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (65828926..65908875, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

homozygous and compound-heterozygous nonsense and frameshift TRIP4 and ASCC1 mutations that cosegregated with the Prenatal Spinal Muscular Atrophy and Congenital Bone Fracture phenotype
Title: Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures.
ASC-1 exists as a steady-state complex associated with three polypeptides, P200, P100, and P50, in HeLa nuclei.
Title: Novel transcription coactivator complex containing activating signal cointegrator 1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125860 (e-PCR)
- UniSTS:162597

NoName (e-PCR)
- UniSTS:236168

NoName (e-PCR)
- UniSTS:236169

BB191711 (e-PCR)
- UniSTS:185792

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone acetyltransferase binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like protein ligase binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rescue of stalled ribosome	ISO Inferred from Sequence Orthology more info
involved_in ribosome disassembly	ISO Inferred from Sequence Orthology more info
involved_in ribosome-associated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of activating signal cointegrator 1 complex	ISO Inferred from Sequence Orthology more info
colocalizes_with centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: activating signal cointegrator 1

Names: TR-interacting protein 4; TRIP-4; thyroid receptor-interacting protein 4; transcription coactivator Asc1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170907.1 → NP_001164378.1 activating signal cointegrator 1 isoform 2

See identical proteins and their annotated locations for NP_001164378.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AC151906, AK039024, AW121332, BB617447

Consensus CDS

CCDS52838.1

UniProtKB/TrEMBL

Q3UJV0

Related

ENSMUSP00000112866.2, ENSMUST00000122410.8

Conserved Domains (2) summary

cd06554
Location:434 → 525

ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...

pfam06221
Location:168 → 216

zf-C2HC5; Putative zinc finger motif, C2HC5-type
NM_001357872.1 → NP_001344801.1 activating signal cointegrator 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (1).

Source sequence(s)

AC151906

Consensus CDS

CCDS23298.1

UniProtKB/Swiss-Prot

E9QK64, Q8CAD5, Q9QXN3

UniProtKB/TrEMBL

Q3UJV0

Related

ENSMUSP00000113949.2, ENSMUST00000117083.2

Conserved Domains (2) summary

cd06554
Location:434 → 547

ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...

pfam06221
Location:168 → 216

zf-C2HC5; Putative zinc finger motif, C2HC5-type
NM_019797.4 → NP_062771.2 activating signal cointegrator 1 isoform 1

See identical proteins and their annotated locations for NP_062771.2

Status: VALIDATED

Description

Transcript Variant: This variant (1, also referred to as the testis specific form) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 3 both encode the same isoform (1).

Source sequence(s)

AC151906, AW121332

Consensus CDS

CCDS23298.1

UniProtKB/Swiss-Prot

E9QK64, Q8CAD5, Q9QXN3

UniProtKB/TrEMBL

Q3UJV0

Related

ENSMUSP00000112385.2, ENSMUST00000119245.8

Conserved Domains (2) summary

cd06554
Location:434 → 547

ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...

pfam06221
Location:168 → 216

zf-C2HC5; Putative zinc finger motif, C2HC5-type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

65736208..65816150 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155144.1 → XP_036011037.1 activating signal cointegrator 1 isoform X2

UniProtKB/TrEMBL

Q3UJV0

Related

ENSMUSP00000137304.2, ENSMUST00000179395.8

Conserved Domains (2) summary

cd06554
Location:434 → 525

ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...

pfam06221
Location:168 → 216

zf-C2HC5; Putative zinc finger motif, C2HC5-type
XM_006511298.5 → XP_006511361.1 activating signal cointegrator 1 isoform X1

See identical proteins and their annotated locations for XP_006511361.1

UniProtKB/Swiss-Prot

E9QK64, Q8CAD5, Q9QXN3

UniProtKB/TrEMBL

Q3UJV0

Conserved Domains (2) summary

cd06554
Location:434 → 547

ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...

pfam06221
Location:168 → 216

zf-C2HC5; Putative zinc finger motif, C2HC5-type
XM_030244463.2 → XP_030100323.1 activating signal cointegrator 1 isoform X1

UniProtKB/Swiss-Prot

E9QK64, Q8CAD5, Q9QXN3

UniProtKB/TrEMBL

Q3UJV0

Conserved Domains (2) summary

cd06554
Location:434 → 547

ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...

pfam06221
Location:168 → 216

zf-C2HC5; Putative zinc finger motif, C2HC5-type
XM_036155143.1 → XP_036011036.1 activating signal cointegrator 1 isoform X2

UniProtKB/TrEMBL

Q3UJV0

Conserved Domains (2) summary

cd06554
Location:434 → 525

ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...

pfam06221
Location:168 → 216

zf-C2HC5; Putative zinc finger motif, C2HC5-type
XM_036155146.1 → XP_036011039.1 activating signal cointegrator 1 isoform X3

UniProtKB/TrEMBL

Q3UBZ2

Conserved Domains (1) summary

pfam06221
Location:168 → 216

zf-C2HC5; Putative zinc finger motif, C2HC5-type