Mrps12 mitochondrial ribosomal protein S12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mrps12provided by MGI
Official Full Name: mitochondrial ribosomal protein S12provided by MGI
Primary source: MGI:MGI:1346333
See related: Ensembl:ENSMUSG00000045948 AllianceGenome:MGI:1346333
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: rps12; Rpms12
Summary: Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPS12 (mitochondrial ribosomal protein S12). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 77.6), duodenum adult (RPKM 43.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 16.91 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (28439066..28441246, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (28739641..28741821, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NF-Y type CCAAT boxes are found preferentially in bidirectional Mrps12/Sarsm promoters, but many such promoters lack them and must be regulated in another way.
Title: NF-Y influences directionality of transcription from the bidirectional Mrps12/Sarsm promoter in both mouse and human cells.
Identification of an array of 4 CCAAT box elements required for efficient transcription of the Mrps12 gene.
Title: The bidirectional promoter of two genes for the mitochondrial translational apparatus in mouse is regulated by an array of CCAAT boxes interacting with the transcription factor NF-Y.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI327385 (e-PCR)
- UniSTS:179544

RH129132 (e-PCR)
- UniSTS:212440

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial translation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in mitochondrial translation	NAS Non-traceable Author Statement more info	PubMed
involved_in translation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	NAS Non-traceable Author Statement more info	PubMed
part_of mitochondrial small ribosomal subunit	ISO Inferred from Sequence Orthology more info
part_of mitochondrial small ribosomal subunit	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of mitochondrial small ribosomal subunit	NAS Non-traceable Author Statement more info	PubMed
located_in mitochondrion	HDA more info	PubMed
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
is_active_in ribosome	IBA Inferred from Biological aspect of Ancestor more info
part_of small ribosomal subunit	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: small ribosomal subunit protein uS12m

Names: 28S ribosomal protein S12, mitochondrial; MRP-S12; MT-RPS12; S12mt; mitoribosomal protein s12; ribosomal protein, mitochondrial, S12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360250.1 → NP_001347179.1 small ribosomal subunit protein uS12m isoform a precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AC171210, CA323119

Consensus CDS

CCDS21052.1

UniProtKB/Swiss-Prot

O35680

UniProtKB/TrEMBL

E9PUY1

Related

ENSMUSP00000132443.2, ENSMUST00000171183.2

Conserved Domains (1) summary

cd03368
Location:32 → 138

Ribosomal_S12; S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit ...
NM_001360252.1 → NP_001347181.1 small ribosomal subunit protein uS12m isoform a precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AC171210

Consensus CDS

CCDS21052.1

UniProtKB/Swiss-Prot

O35680

UniProtKB/TrEMBL

E9PUY1

Conserved Domains (1) summary

cd03368
Location:32 → 138

Ribosomal_S12; S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit ...
NM_001360254.1 → NP_001347183.1 small ribosomal subunit protein uS12m isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AA606858, AC171210

UniProtKB/TrEMBL

E9PUY1

Related

ENSMUSP00000129492.2, ENSMUST00000165004.2
NM_011885.5 → NP_036015.1 small ribosomal subunit protein uS12m isoform a precursor

See identical proteins and their annotated locations for NP_036015.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AC171210, Y11682

Consensus CDS

CCDS21052.1

UniProtKB/Swiss-Prot

O35680

UniProtKB/TrEMBL

E9PUY1

Related

ENSMUSP00000062066.9, ENSMUST00000056078.9

Conserved Domains (1) summary

cd03368
Location:32 → 138

Ribosomal_S12; S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit ...