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    Stk40 serine/threonine kinase 40 [ Mus musculus (house mouse) ]

    Gene ID: 74178, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Stk40provided by MGI
    Official Full Name
    serine/threonine kinase 40provided by MGI
    Primary source
    MGI:MGI:1921428
    See related
    Ensembl:ENSMUSG00000042608 AllianceGenome:MGI:1921428
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310004N11Rik
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Acts upstream of or within several processes, including glycogen metabolic process; lung development; and respiratory system process. Predicted to be located in cytosol and nucleoplasm. Is expressed in alimentary system; central nervous system; pharyngo-tympanic tube; and skin. Orthologous to human STK40 (serine/threonine kinase 40). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 18.0), lung adult (RPKM 15.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D2.2; 4 59.89 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (125997738..126034822)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126103942..126141029)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene organic solute carrier partner 1 Neighboring gene ribosomal protein L28, pseudogene 3 Neighboring gene STARR-positive B cell enhancer ABC_E2712 Neighboring gene STARR-positive B cell enhancer ABC_E2713 Neighboring gene U7 snRNP-specific Sm-like protein LSM10 Neighboring gene eva-1 homolog B Neighboring gene SH3 domain containing 21 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:125839584-125839767

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Analysis of transcription factor Stk40 expression and function during mouse pre-implantation embryonic development. Zhang J, et al. Mol Med Rep, 2014 Feb. PMID 24276375
    2. EZH2-mediated inhibition of microRNA-22 promotes differentiation of hair follicle stem cells by elevating STK40 expression. Cai B, et al. Aging (Albany NY), 2020 Jul 12. PMID 32657761, Free PMC Article
    3. Stk40 represses adipogenesis through translational control of CCAAT/enhancer-binding proteins. Yu H, et al. J Cell Sci, 2015 Aug 1. PMID 26065429
    4. Hypoxic preconditioning induces stroke tolerance in mice via a cascading HIF, sphingosine kinase, and CCL2 signaling pathway. Wacker BK, et al. J Neurochem, 2012 Dec. PMID 23043544, Free PMC Article
    5. Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation. Li L, et al. Proc Natl Acad Sci U S A, 2010 Jan 26. PMID 20080709, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EZH2-mediated inhibition of microRNA-22 promotes differentiation of hair follicle stem cells by elevating STK40 expression.
      Title: EZH2-mediated inhibition of microRNA-22 promotes differentiation of hair follicle stem cells by elevating STK40 expression.
    2. comparison of microarray data between wild type and Stk40(-/-) E14.5 fetal liver cells reveals a potential role of aberrantly activated TNF-alpha signaling in Stk40 depletion induced dyserythropoiesis with a concomitant increase in cleaved caspase-3 and decrease in Gata1 proteins.
      Title: Deletion of Stk40 impairs definitive erythropoiesis in the mouse fetal liver.
    3. Loss of Stk40 is associated with impaired fetal skeletal muscle formation.
      Title: Serine/Threonine Kinase 40 (Stk40) Functions as a Novel Regulator of Skeletal Muscle Differentiation.
    4. CCAAT/enhancer-binding protein (C/EBP) beta and C/EBPdelta, two crucial pro-adipogenic transcription factors, are controlled at a translational level by serine/threonine kinase 40 (Stk40).
      Title: Stk40 represses adipogenesis through translational control of CCAAT/enhancer-binding proteins.
    5. the results suggested that Stk40 may be critical in the development of preimplantation embryos.
      Title: Analysis of transcription factor Stk40 expression and function during mouse pre-implantation embryonic development.
    6. Deletion of STK40 protein in mice causes respiratory failure and death at birth
      Title: Deletion of STK40 protein in mice causes respiratory failure and death at birth.
    7. report identification of a target gene of Oct4, serine/threonine kinase 40 (Stk40), which is able to activate the Erk/MAPK pathway and induce extraembryonic-endoderm (ExEn) differentiation in mouse embryonic stem cells.
      Title: Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within glycogen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lung development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within respiratory system process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 40
    Names
    ortholog of Ser/Thr-like protein kinase Lyk4
    serine/threonine-protein kinase lyk4
    NP_001139299.1
    NP_083076.3
    XP_006503504.1
    XP_006503505.1
    XP_017175903.1
    XP_036020388.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145827.1 → NP_001139299.1  serine/threonine-protein kinase 40 isoform a

      See identical proteins and their annotated locations for NP_001139299.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AL731780, AY336057, BQ030783, CJ170090, DV660319
      Consensus CDS
      CCDS51299.1
      UniProtKB/Swiss-Prot
      Q7TNL3
      Related
      ENSMUSP00000111990.3, ENSMUST00000116286.9
      Conserved Domains (1) summary
      cd13974
      Location:52 → 344
      STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase

    2. NM_028800.3 → NP_083076.3  serine/threonine-protein kinase 40 isoform b

      See identical proteins and their annotated locations for NP_083076.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AY336057, BQ030783, CJ170090, DV660319
      Consensus CDS
      CCDS51300.1
      UniProtKB/Swiss-Prot
      B1AW01, Q3U3G3, Q7TNL3, Q811D6, Q8BKT1, Q9D7K3
      Related
      ENSMUSP00000092354.5, ENSMUST00000094761.11
      Conserved Domains (1) summary
      cd13974
      Location:38 → 330
      STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      125997738..126034822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320414.3 → XP_017175903.1  serine/threonine-protein kinase 40 isoform X2

      UniProtKB/Swiss-Prot
      B1AW01, Q3U3G3, Q7TNL3, Q811D6, Q8BKT1, Q9D7K3
      Conserved Domains (1) summary
      cd13974
      Location:38 → 330
      STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase

    2. XM_006503442.3 → XP_006503505.1  serine/threonine-protein kinase 40 isoform X2

      See identical proteins and their annotated locations for XP_006503505.1

      UniProtKB/Swiss-Prot
      B1AW01, Q3U3G3, Q7TNL3, Q811D6, Q8BKT1, Q9D7K3
      Conserved Domains (1) summary
      cd13974
      Location:38 → 330
      STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase

    3. XM_006503441.5 → XP_006503504.1  serine/threonine-protein kinase 40 isoform X1

      See identical proteins and their annotated locations for XP_006503504.1

      UniProtKB/Swiss-Prot
      Q7TNL3
      Conserved Domains (1) summary
      cd13974
      Location:52 → 344
      STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase

    4. XM_036164495.1 → XP_036020388.1  serine/threonine-protein kinase 40 isoform X2

      UniProtKB/Swiss-Prot
      B1AW01, Q3U3G3, Q7TNL3, Q811D6, Q8BKT1, Q9D7K3
      Conserved Domains (1) summary
      cd13974
      Location:38 → 330
      STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TNL3.1 GenPept UniProtKB/Swiss-Prot:Q7TNL3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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