Slu7 SLU7 splicing factor homolog (S. cerevisiae) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slu7provided by MGI
Official Full Name: SLU7 splicing factor homolog (S. cerevisiae)provided by MGI
Primary source: MGI:MGI:2385598
See related: Ensembl:ENSMUSG00000020409 AllianceGenome:MGI:2385598
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D3Bwg0878e; D11Ertd730e
Summary: Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 6.7), cerebellum adult (RPKM 5.2) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.1; 11 25.68 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (43324550..43338809)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (43433726..43447982)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4alpha Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage.
Title: Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage.
Knockdown of hepatic Slu7 by adenovirus-Slu7shRNA treatment ameliorated inflammation and attenuated liver injury in mice after ethanol administration.
Title: Hepatic Knockdown of Splicing Regulator Slu7 Ameliorates Inflammation and Attenuates Liver Injury in Ethanol-Fed Mice.
SLU7 knockdown in liver resulted in profound changes in pre-mRNA splicing and gene expression, leading to impaired glucose and lipid metabolism, refractoriness to key metabolic hormones, and reversion to a fetal-like gene expression pattern.
Title: Splicing regulator SLU7 is essential for maintaining liver homeostasis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE200474 (e-PCR)
- UniSTS:208661

BB260036 (e-PCR)
- UniSTS:208662

01.MMHAP59FRA7.seq (e-PCR)
- UniSTS:122661

D3Bwg0878e (e-PCR), detects polymorphism
- UniSTS:142382

Slu7 (e-PCR), detects polymorphism
- UniSTS:507444

RH136514 (e-PCR)
- UniSTS:210496

D11Ertd730e (e-PCR), detects polymorphism
- UniSTS:167077

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables pre-mRNA 3'-splice site binding	ISO Inferred from Sequence Orthology more info
enables second spliceosomal transesterification activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA splicing, via transesterification reactions	ISO Inferred from Sequence Orthology more info
involved_in alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in mRNA 3'-splice site recognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of small nuclear ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info
part_of spliceosomal complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pre-mRNA-splicing factor SLU7

Names: step II splicing factor SLU7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_148673.3 → NP_683514.2 pre-mRNA-splicing factor SLU7

See identical proteins and their annotated locations for NP_683514.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK029117, AK047597, BY243619

Consensus CDS

CCDS24557.1

UniProtKB/Swiss-Prot

Q3KQQ3, Q5SRU1, Q63ZX3, Q6P923, Q8BHJ9, Q8BL59, Q8BXD5, Q8R5C1, Q91YV6

UniProtKB/TrEMBL

Z4YM25

Related

ENSMUSP00000116609.2, ENSMUST00000151880.8

Conserved Domains (1) summary

pfam11708
Location:161 → 434

Slu7; Pre-mRNA splicing Prp18-interacting factor
NM_198936.1 → NP_945174.1 pre-mRNA-splicing factor SLU7

See identical proteins and their annotated locations for NP_945174.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an additional segment in its 5' UTR when compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK029117, AK047597, BY243619

Consensus CDS

CCDS24557.1

UniProtKB/Swiss-Prot

Q3KQQ3, Q5SRU1, Q63ZX3, Q6P923, Q8BHJ9, Q8BL59, Q8BXD5, Q8R5C1, Q91YV6

UniProtKB/TrEMBL

Z4YM25

Related

ENSMUSP00000020681.4, ENSMUST00000020681.10

Conserved Domains (1) summary

pfam11708
Location:161 → 434

Slu7; Pre-mRNA splicing Prp18-interacting factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

43324550..43338809

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011248823.3 → XP_011247125.1 pre-mRNA-splicing factor SLU7 isoform X1

See identical proteins and their annotated locations for XP_011247125.1

UniProtKB/Swiss-Prot

Q3KQQ3, Q5SRU1, Q63ZX3, Q6P923, Q8BHJ9, Q8BL59, Q8BXD5, Q8R5C1, Q91YV6

UniProtKB/TrEMBL

Z4YM25

Conserved Domains (1) summary

pfam11708
Location:161 → 434

Slu7; Pre-mRNA splicing Prp18-interacting factor
XM_036156451.1 → XP_036012344.1 pre-mRNA-splicing factor SLU7 isoform X2

Conserved Domains (1) summary

pfam11708
Location:2 → 275

Slu7; Pre-mRNA splicing Prp18-interacting factor