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    Ddx50 DExD box helicase 50 [ Mus musculus (house mouse) ]

    Gene ID: 94213, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Ddx50provided by MGI
    Official Full Name
    DExD box helicase 50provided by MGI
    Primary source
    MGI:MGI:2182303
    See related
    Ensembl:ENSMUSG00000020076 AllianceGenome:MGI:2182303
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GU2; RH-II; 4933429B04Rik; 8430408E17Rik
    Summary
    Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be located in plasma membrane. Predicted to be active in nucleolus. Is expressed in embryo. Orthologous to human DDX50 (DExD-box helicase 50). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 26.0), bladder adult (RPKM 19.0) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 B4; 10 32.44 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62451571..62487260, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62615792..62658764, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26888 Neighboring gene kinesin family binding protein Neighboring gene STARR-positive B cell enhancer ABC_E3889 Neighboring gene STARR-positive B cell enhancer ABC_E8339 Neighboring gene DExD box helicase 21 Neighboring gene STARR-positive B cell enhancer ABC_E10615 Neighboring gene STARR-seq mESC enhancer starr_26889 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:62114124-62114233 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:62127774-62127957 Neighboring gene predicted gene, 51417 Neighboring gene storkhead box 1 Neighboring gene crumbs homolog 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genomic structure of newly identified paralogue of RNA helicase II/Gu: detection of pseudogenes and multiple alternatively spliced mRNAs. Valdez BC, et al. Gene, 2002 Feb 6. PMID 11891046
    2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    4. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
    5. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase DDX50
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
    DEAD box protein 50
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 50
    RH-II/Gubeta
    gu-beta
    nucleolar protein GU2
    NP_001345748.1
    NP_001345749.1
    NP_444413.1
    XP_006514408.1
    XP_011241910.1
    XP_030101267.1
    XP_030101268.1
    XP_030101269.1
    XP_030101270.1
    XP_036012018.1
    XP_036012019.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358819.1 → NP_001345748.1  ATP-dependent RNA helicase DDX50 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC121961, AK041281, AK162423
      UniProtKB/TrEMBL
      Q5BKP5, Q8BRU5
      Conserved Domains (3) summary
      COG0513
      Location:65 → 543
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd12936
      Location:500 → 591
      GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
      cd17944
      Location:80 → 281
      DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50

    2. NM_001358820.1 → NP_001345749.1  ATP-dependent RNA helicase DDX50 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK030239, AK041281, CF898436
      UniProtKB/TrEMBL
      Q5BKP5, Q8BRU5
      Related
      ENSMUST00000218372.2
      Conserved Domains (3) summary
      COG0513
      Location:65 → 543
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd12936
      Location:500 → 591
      GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
      cd17944
      Location:80 → 281
      DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50

    3. NM_053183.3 → NP_444413.1  ATP-dependent RNA helicase DDX50 isoform 1

      See identical proteins and their annotated locations for NP_444413.1

      Status: VALIDATED

      Source sequence(s)
      AC121961, AK041281, AK162423
      Consensus CDS
      CCDS23892.1
      UniProtKB/Swiss-Prot
      Q99MJ9
      UniProtKB/TrEMBL
      Q5BKP5
      Related
      ENSMUSP00000020270.5, ENSMUST00000020270.6
      Conserved Domains (4) summary
      COG0513
      Location:130 → 608
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00079
      Location:369 → 486
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:136 → 339
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      cd12936
      Location:565 → 656
      GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      62451571..62487260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514345.5 → XP_006514408.1  ATP-dependent RNA helicase DDX50 isoform X1

      UniProtKB/TrEMBL
      Q5BKP5
      Conserved Domains (3) summary
      COG0513
      Location:130 → 554
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd12936
      Location:511 → 602
      GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
      cd17944
      Location:145 → 346
      DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50

    2. XM_030245409.2 → XP_030101269.1  ATP-dependent RNA helicase DDX50 isoform X3

      Conserved Domains (3) summary
      COG0513
      Location:65 → 489
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd12936
      Location:446 → 537
      GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
      cd17944
      Location:80 → 281
      DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50

    3. XM_011243608.4 → XP_011241910.1  ATP-dependent RNA helicase DDX50 isoform X4

      Conserved Domains (2) summary
      COG0513
      Location:1 → 317
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd12936
      Location:274 → 365
      GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins

    4. XM_030245410.2 → XP_030101270.1  ATP-dependent RNA helicase DDX50 isoform X4

      Conserved Domains (2) summary
      COG0513
      Location:1 → 317
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd12936
      Location:274 → 365
      GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins

    5. XM_036156125.1 → XP_036012018.1  ATP-dependent RNA helicase DDX50 isoform X4

      Conserved Domains (2) summary
      COG0513
      Location:1 → 317
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd12936
      Location:274 → 365
      GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins

    6. XM_036156126.1 → XP_036012019.1  ATP-dependent RNA helicase DDX50 isoform X5

      Conserved Domains (3) summary
      COG0513
      Location:1 → 263
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd12936
      Location:220 → 311
      GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
      cl28899
      Location:1 → 55
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    7. XM_030245408.2 → XP_030101268.1  ATP-dependent RNA helicase DDX50 isoform X2

      UniProtKB/TrEMBL
      Q5BKP5, Q8BRU5
      Conserved Domains (3) summary
      COG0513
      Location:65 → 543
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd12936
      Location:500 → 591
      GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
      cd17944
      Location:80 → 281
      DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50

    8. XM_030245407.2 → XP_030101267.1  ATP-dependent RNA helicase DDX50 isoform X2

      UniProtKB/TrEMBL
      Q5BKP5, Q8BRU5
      Conserved Domains (3) summary
      COG0513
      Location:65 → 543
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd12936
      Location:500 → 591
      GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
      cd17944
      Location:80 → 281
      DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MJ9.1 GenPept UniProtKB/Swiss-Prot:Q99MJ9

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