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    Dusp11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) [ Mus musculus (house mouse) ]

    Gene ID: 72102, updated on 12-May-2024

    Summary

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    Official Symbol
    Dusp11provided by MGI
    Official Full Name
    dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)provided by MGI
    Primary source
    MGI:MGI:1919352
    See related
    Ensembl:ENSMUSG00000030002 AllianceGenome:MGI:1919352
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010300F21Rik
    Summary
    Predicted to enable RNA binding activity and phosphatase activity. Predicted to be involved in RNA metabolic process; polynucleotide 5' dephosphorylation; and protein dephosphorylation. Predicted to be located in fibrillar center; intercellular bridge; and nuclear speck. Is expressed in central nervous system and retina. Orthologous to human DUSP11 (dual specificity phosphatase 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 27.2), whole brain E14.5 (RPKM 25.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 C3; 6 37.54 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (85919250..85938950, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (85942268..85961732, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:85887170-85887279 Neighboring gene N-acetyltransferase 8B, pseudogene Neighboring gene prohibitin pseudogene Neighboring gene uncharacterized LOC118567396 Neighboring gene STARR-positive B cell enhancer ABC_E6449 Neighboring gene predicted gene, 33319 Neighboring gene STARR-seq mESC enhancer starr_16515 Neighboring gene RIKEN cDNA 4930553P18 gene Neighboring gene folliculogenesis specific basic helix-loop-helix

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DUSP11 Attenuates Lipopolysaccharide-Induced Macrophage Activation by Targeting TAK1. Yang CY, et al. J Immunol, 2020 Sep 15. PMID 32796023, Free PMC Article
    2. DUSP11-mediated control of 5'-triphosphate RNA regulates RIG-I sensitivity. Choi JH, et al. Genes Dev, 2020 Dec 1. PMID 33184222, Free PMC Article
    3. A growing family of dual specificity phosphatases with low molecular masses. Aoki N, et al. J Biochem, 2001 Jul. PMID 11432789
    4. Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss. Celaya AM, et al. Elife, 2019 Apr 2. PMID 30938680, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polynucleotide 5'-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polynucleotide 5'-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA/RNP complex-1-interacting phosphatase
    Names
    phosphatase that interacts with RNA/RNP complex 1
    NP_082375.4
    XP_011239778.1
    XP_017177243.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028099.4 → NP_082375.4  RNA/RNP complex-1-interacting phosphatase

      See identical proteins and their annotated locations for NP_082375.4

      Status: VALIDATED

      Source sequence(s)
      AK089506, BB613140, BC055282, BC067028
      Consensus CDS
      CCDS20306.1
      UniProtKB/Swiss-Prot
      Q6NXK5, Q8BTR4, Q8BYE4
      Related
      ENSMUSP00000032071.10, ENSMUST00000032071.13
      Conserved Domains (1) summary
      cl21483
      Location:119 → 195
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      85919250..85938950 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321754.2 → XP_017177243.1  RNA/RNP complex-1-interacting phosphatase isoform X1

      Conserved Domains (1) summary
      cl28904
      Location:2 → 136
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. XM_011241476.3 → XP_011239778.1  RNA/RNP complex-1-interacting phosphatase isoform X2

      See identical proteins and their annotated locations for XP_011239778.1

      UniProtKB/TrEMBL
      Q9D851
      Conserved Domains (1) summary
      cl28904
      Location:1 → 29
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    RNA

    1. XR_001785172.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NXK5.1 GenPept UniProtKB/Swiss-Prot:Q6NXK5

    Gene LinkOut

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