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    Tcp10a t-complex protein 10a [ Mus musculus (house mouse) ]

    Gene ID: 21461, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tcp10aprovided by MGI
    Official Full Name
    t-complex protein 10aprovided by MGI
    Primary source
    MGI:MGI:98541
    See related
    Ensembl:ENSMUSG00000071322 AllianceGenome:MGI:98541
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    T66A-a; Gm10326; Tcp-10a; D17Leh66A; D17Leh66aa
    Summary
    Predicted to enable several functions, including identical protein binding activity; protein self-association; and transcription corepressor activity. Predicted to be active in centriole and nucleus. Orthologous to several human genes including TCP10L (t-complex 10 like) and TCP10L2 (t-complex 10 like 2, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 142.0) See more
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    Genomic context

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    Location:
    17 4.72 cM; 17 A1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (7592055..7613259)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (7324656..7345860)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41745 Neighboring gene ribosomal protein S6 kinase, polypeptide 2 Neighboring gene STARR-positive B cell enhancer mm9_chr17:7374004-7374305 Neighboring gene STARR-seq mESC enhancer starr_41746 Neighboring gene VISTA enhancer mm108 Neighboring gene STARR-seq mESC enhancer starr_41751 Neighboring gene G protein-coupled receptor 31, D17Leh66a region Neighboring gene tubulin tyrosine ligase-like family, member 2 Neighboring gene unc-93 homolog A2 Neighboring gene predicted gene, 26057

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional and molecular characterization of the transcriptional regulatory region of Tcp-10bt, a testes-expressed gene from the t complex responder locus. Ewulonu UK, et al. Development, 1993 Jan. PMID 8223262
    2. Concerted evolution of the mouse Tcp-10 gene family: implications for the functional basis of t haplotype transmission ratio distortion. Pilder SH, et al. Genomics, 1992 Jan. PMID 1339385
    3. Targeted mutagenesis of a candidate t complex responder gene in mouse t haplotypes does not eliminate transmission ratio distortion. Ewulonu UK, et al. Genetics, 1996 Oct. PMID 8889539, Free PMC Article
    4. The human homolog of a candidate mouse t complex responder gene: conserved motifs and evolution with punctuated equilibria. Islam SD, et al. Hum Mol Genet, 1993 Dec. PMID 8111376
    5. An unstable family of large DNA elements in the center of the mouse t complex. Schimenti J, et al. J Mol Biol, 1987 Apr 20. PMID 2821263

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC184383

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    t-complex protein 10a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011553.4 → NP_035683.2  t-complex protein 10a

      See identical proteins and their annotated locations for NP_035683.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript.
      Source sequence(s)
      AC117241, AK161455
      Consensus CDS
      CCDS28377.1
      UniProtKB/TrEMBL
      B2RUN1, Q80W76
      Related
      ENSMUSP00000093394.5, ENSMUST00000095726.11
      Conserved Domains (2) summary
      pfam07202
      Location:263 → 436
      Tcp10_C; T-complex protein 10 C-terminus
      pfam15030
      Location:19 → 103
      DUF4527; Protein of unknown function (DUF4527)

    RNA

    1. NR_046291.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' end, compared to variant 1, resulting in a longer transcript. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC117241, BC052353

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      7592055..7613259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523213.3 → XP_006523276.1  t-complex protein 10a isoform X1

      UniProtKB/TrEMBL
      B2RUN1
      Conserved Domains (1) summary
      pfam07202
      Location:230 → 404
      Tcp10_C; T-complex protein 10 C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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