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    Slc45a1 solute carrier family 45, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 242773, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Slc45a1provided by MGI
    Official Full Name
    solute carrier family 45, member 1provided by MGI
    Primary source
    MGI:MGI:2653235
    See related
    Ensembl:ENSMUSG00000039838 AllianceGenome:MGI:2653235
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dnb5; PAST-A; C230078B22
    Summary
    Predicted to enable glucose transmembrane transporter activity and sucrose:proton symporter activity. Predicted to be involved in glucose transmembrane transport. Predicted to act upstream of or within carbohydrate transport. Predicted to be integral component of membrane. Predicted to be active in membrane. Is expressed in medulla oblongata basal plate and ventral grey horn. Orthologous to human SLC45A1 (solute carrier family 45 member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 14.7), cortex adult (RPKM 10.6) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 E2; 4 81.44 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (150713853..150736614, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (150629396..150652176, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene arginine glutamic acid dipeptide (RE) repeats Neighboring gene RIKEN cDNA E230012J19 gene Neighboring gene STARR-positive B cell enhancer mm9_chr4:149809745-149810046 Neighboring gene STARR-seq mESC enhancer starr_12156 Neighboring gene predicted gene, 52709 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:149919109-149919262 Neighboring gene STARR-positive B cell enhancer ABC_E6288 Neighboring gene STARR-positive B cell enhancer ABC_E2732 Neighboring gene STARR-seq mESC enhancer starr_12163 Neighboring gene STARR-seq mESC enhancer starr_12165 Neighboring gene STARR-seq mESC enhancer starr_12167 Neighboring gene STARR-seq mESC enhancer starr_12169 Neighboring gene predicted gene, 36600 Neighboring gene predicted gene, 54271

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dysfunction of the Cerebral Glucose Transporter SLC45A1 in Individuals with Intellectual Disability and Epilepsy. Srour M, et al. Am J Hum Genet, 2017 May 4. PMID 28434495, Free PMC Article
    2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables galactose:proton symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucose:proton symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glucose:proton symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sucrose:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in galactose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glucose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    proton-associated sugar transporter A
    Names
    DNb-5 homolog
    deleted in neuroblastoma 5 protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355737.2 → NP_001342666.1  proton-associated sugar transporter A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606982
      Conserved Domains (1) summary
      cl28910
      Location:324 → 546
      MFS; Major Facilitator Superfamily

    2. NM_001425825.1 → NP_001412754.1  proton-associated sugar transporter A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL606982

    3. NM_001425826.1 → NP_001412755.1  proton-associated sugar transporter A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606982

    4. NM_001425827.1 → NP_001412756.1  proton-associated sugar transporter A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606982

    5. NM_173774.4 → NP_776135.2  proton-associated sugar transporter A isoform 1

      See identical proteins and their annotated locations for NP_776135.2

      Status: VALIDATED

      Source sequence(s)
      AL606982
      Consensus CDS
      CCDS18973.1
      UniProtKB/Swiss-Prot
      Q3TZ98, Q8BIV7
      UniProtKB/TrEMBL
      B0QZL3
      Related
      ENSMUSP00000036774.4, ENSMUST00000037827.10
      Conserved Domains (1) summary
      TIGR01301
      Location:83 → 293
      GPH_sucrose; GPH family sucrose/H+ symporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      150713853..150736614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BIV7.3 GenPept UniProtKB/Swiss-Prot:Q8BIV7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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