Cyp4x1 cytochrome P450, family 4, subfamily x, polypeptide 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp4x1provided by MGI
Official Full Name: cytochrome P450, family 4, subfamily x, polypeptide 1provided by MGI
Primary source: MGI:MGI:1932403
See related: Ensembl:ENSMUSG00000047155 AllianceGenome:MGI:1932403
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CYP_a; CYPIVX1; A230025G20; Cyp4a28-ps
Summary: Predicted to enable anandamide 14,15 epoxidase activity; arachidonic acid 14,15-epoxygenase activity; and fatty acid in-chain hydroxylase activity. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including genitourinary system; heart; nervous system; and neural retina. Orthologous to several human genes including CYP4X1 (cytochrome P450 family 4 subfamily X member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 3.7), cortex adult (RPKM 2.3) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D1; 4 52.76 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (114963518..114991276, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (115106323..115134079, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cyp4x RNA was expressed principally in brain, and at much lower levels in liver
Title: Cytochrome P450 Cyp4x1 is a major P450 protein in mouse brain.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:490782

Cyp4x1 (e-PCR), detects polymorphism
- UniSTS:468832

UniSTS:495977 (e-PCR)
- UniSTS:495977

Avpr1b (e-PCR), detects polymorphism
- UniSTS:495977

px-38e3 (e-PCR)
- UniSTS:257695

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables anandamide 14,15 epoxidase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 4X1

NP_001003947.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.