Sycp1 synaptonemal complex protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sycp1provided by MGI
Official Full Name: synaptonemal complex protein 1provided by MGI
Primary source: MGI:MGI:105931
See related: Ensembl:ENSMUSG00000027855 AllianceGenome:MGI:105931
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SCP1
Summary: Predicted to enable double-stranded DNA binding activity. Involved in reciprocal meiotic recombination and synaptonemal complex assembly. Acts upstream of or within meiosis I cell cycle process; regulation of protein localization; and sperm chromatin condensation. Located in central element; male germ cell nucleus; and transverse filament. Is expressed in brain and reproductive system. Orthologous to human SYCP1 (synaptonemal complex protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 3.6), cerebellum adult (RPKM 0.7) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 3 F2.2; 3 45.25 cM

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (102725815..102843416, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (102818499..102936100, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SYCP1 head-to-head assembly is required for chromosome synapsis in mouse meiosis.
Title: SYCP1 head-to-head assembly is required for chromosome synapsis in mouse meiosis.
Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3.
Title: Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3.
LncRNA-Gm2044 is transcriptionally activated by A-MYB and regulates Sycp1 expression as a miR-335-3p sponge in mouse spermatocyte-derived GC-2spd(ts) cells.
Title: LncRNA-Gm2044 is transcriptionally activated by A-MYB and regulates Sycp1 expression as a miR-335-3p sponge in mouse spermatocyte-derived GC-2spd(ts) cells.
SCRE interacts with synaptonemal complex protein 1 (SYCP1) and synaptonemal complex central element 3 (SYCE3); the function of SCRE is to reinforce the integrity of the central elements, thereby stabilizing the SC and ensuring meiotic cell cycle progression
Title: SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice.
In addition to these female-specific features, we speculate that post-translation modifications affecting the SYCP1 coiled-coil region could render a more compact conformation, thus contributing to the narrower SC observed in females.
Title: Sexual dimorphism in the width of the mouse synaptonemal complex.
Sororin localizes to the cores of meiotic chromosomes in a manner that is dependent on synapsis and the synaptonemal complex protein SYCP1.
Title: Sororin is enriched at the central region of synapsed meiotic chromosomes.
PLK1, but not PLK2-4, phosphorylates central element proteins SYCP1 and TEX12.
Title: Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes.
SYCP1 and SYCP3 act at the centromeres to promote the establishment and/or maintenance of centromere pairing and, by doing so, improve the segregation fidelity of mammalian meiotic chromosomes.
Title: Synaptonemal complex components persist at centromeres and are required for homologous centromere pairing in mouse spermatocytes.
SYCP1 has a coordinating role, and ensures formation of crossovers
Title: Mouse Sycp1 functions in synaptonemal complex assembly, meiotic recombination, and XY body formation.
The localisation of Syce1 and Cesc1 (Syce2) to the central element depends on recruitment by Sycp1.
Title: Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

mScp1 (e-PCR)
- UniSTS:514590

Sycp1 (e-PCR), detects polymorphism
- UniSTS:265268

Sycp1 (e-PCR), detects polymorphism
- UniSTS:525726

Sycp1 (e-PCR), detects polymorphism
- UniSTS:547745

Sycp1 (e-PCR), detects polymorphism
- UniSTS:275903

Z38118 (e-PCR)
- UniSTS:163325

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in chiasma assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chiasma assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in homologous chromosome pairing at meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lateral element assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lateral element assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in meiotic DNA repair synthesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within meiotic DNA repair synthesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within meiotic DNA repair synthesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sperm DNA condensation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within spermatogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptonemal complex assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within synaptonemal complex assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within synaptonemal complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptonemal complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in autosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in central element	IBA Inferred from Biological aspect of Ancestor more info
located_in central element	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in lateral element	TAS Traceable Author Statement more info	PubMed
is_active_in male germ cell nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in synaptonemal complex	IDA Inferred from Direct Assay more info	PubMed
located_in synaptonemal complex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in synaptonemal complex	ISO Inferred from Sequence Orthology more info
located_in synaptonemal complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in transverse filament	IBA Inferred from Biological aspect of Ancestor more info
located_in transverse filament	IDA Inferred from Direct Assay more info	PubMed
located_in transverse filament	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: synaptonemal complex protein 1

Names: SCP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011516.2 → NP_035646.2 synaptonemal complex protein 1

See identical proteins and their annotated locations for NP_035646.2

Status: VALIDATED

Source sequence(s)

AK015000, AK076780, AK133229, AV275615

Consensus CDS

CCDS38567.1

UniProtKB/Swiss-Prot

B2RQK2, E9QP17, O09205, P70192, Q62209, Q62329

Related

ENSMUSP00000029448.7, ENSMUST00000029448.11

Conserved Domains (1) summary

pfam05483
Location:28 → 805

SCP-1; Synaptonemal complex protein 1 (SCP-1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

102725815..102843416 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501229.1 → XP_006501292.1 synaptonemal complex protein 1 isoform X1

Conserved Domains (1) summary

pfam05483
Location:1 → 588

SCP-1; Synaptonemal complex protein 1 (SCP-1)