Ptgds prostaglandin D2 synthase (brain) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptgdsprovided by MGI
Official Full Name: prostaglandin D2 synthase (brain)provided by MGI
Primary source: MGI:MGI:99261
See related: Ensembl:ENSMUSG00000015090 AllianceGenome:MGI:99261
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PGD2; PGDS; 21kDa; PGDS2; Ptgs3; L-PGDS
Summary: Enables prostaglandin-D synthase activity and retinoid binding activity. Involved in prostaglandin biosynthetic process and regulation of circadian sleep/wake cycle, sleep. Acts upstream of or within negative regulation of male germ cell proliferation. Located in extracellular region. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PTGDS (prostaglandin D2 synthase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 446.8), frontal lobe adult (RPKM 410.4) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 17.28 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (25356723..25360080, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (25466709..25470110, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Substrate-induced product-release mechanism of lipocalin-type prostaglandin D synthase.
Title: Substrate-induced product-release mechanism of lipocalin-type prostaglandin D synthase.
Lipocalin-type prostaglandin D2 synthase deletion induces dyslipidemia and non-alcoholic fatty liver disease.
Title: Lipocalin-type prostaglandin D(2) synthase deletion induces dyslipidemia and non-alcoholic fatty liver disease.
L-PGDS deficiency accelerated the development of naturally occurring age-related osteoarthritis.
Title: L-PGDS deficiency accelerated the development of naturally occurring age-related osteoarthritis.
Role of Lipocalin-Type Prostaglandin D Synthase in Experimental Osteoarthritis.
Title: Role of Lipocalin-Type Prostaglandin D Synthase in Experimental Osteoarthritis.
L-PGDS-produced PGD2 in premature, but not in mature, adipocytes increases obesity and insulin resistance.
Title: L-PGDS-produced PGD(2) in premature, but not in mature, adipocytes increases obesity and insulin resistance.
PGDS2 expression is modulated after sciatic nerve injury and regulates macrophage phagocytic activity.
Title: Prostaglandin D2 synthase modulates macrophage activity and accumulation in injured peripheral nerves.
interacts with voltage-gated CaV2.2 calcium channels
Title: Four novel interaction partners demonstrate diverse modulatory effects on voltage-gated Ca(V)2.2 Ca(2+) channels.
These observations suggest that tumor cell-derived inflammatory cytokines increase L-PGDS expression and subsequent PGD2 production in the tumor endothelial cells (ECs). This PGD2 acts as a negative regulator of the tumorigenic changes in tumor ECs.
Title: Lipocalin-type prostaglandin D synthase-derived PGD(2) attenuates malignant properties of tumor endothelial cells.
Exposure of macrophages to cyclooxygenase (COX-2) inhibitors RhoA and LA-4 cells to antagonists of prostaglandin E2 (PGE2) receptor , PGD2 receptors or the hepatocyte growth factor (HGF) receptor c-Met (PHA-665752), reversed EMT inhibition by the conditioned medium
Title: Macrophages programmed by apoptotic cells inhibit epithelial-mesenchymal transition in lung alveolar epithelial cells via PGE2, PGD2, and HGF.
Ptgds is targeted and repressed by the CUL4B/PRC2 complex.
Title: Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain.

Submit: New GeneRIF Correction See all GeneRIFs (56)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ptgds (e-PCR), detects polymorphism
- UniSTS:464687

Ptgds (e-PCR), detects polymorphism
- UniSTS:507977

Ptgds (e-PCR), detects polymorphism
- UniSTS:498324

PMC27130P5 (e-PCR)
- UniSTS:272379

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin-D synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin-D synthase activity	ISO Inferred from Sequence Orthology more info
enables retinoid binding	IDA Inferred from Direct Assay more info	PubMed
enables retinoid binding	ISO Inferred from Sequence Orthology more info
enables small molecule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mast cell degranulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of male germ cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in prostaglandin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostaglandin metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of circadian sleep/wake cycle, sleep	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in rough endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prostaglandin-H2 D-isomerase

Names: PGD2 synthase; glutathione-independent PGD synthase; glutathione-independent PGD synthetase; lipocalin-type prostaglandin-D synthase; prostaglandin D2 synthase (21 kDa, brain); prostaglandin-D2 synthase

NP_001407673.1

EC 5.3.99.2

NP_001407674.1

EC 5.3.99.2

NP_001407675.1

EC 5.3.99.2

NP_032989.2

EC 5.3.99.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001420744.1 → NP_001407673.1 prostaglandin-H2 D-isomerase precursor

Status: VALIDATED

Source sequence(s)

AL732557

UniProtKB/Swiss-Prot

O09114, O09157, O35091, Q3V2G5, Q62169
NM_001420745.1 → NP_001407674.1 prostaglandin-H2 D-isomerase precursor

Status: VALIDATED

Source sequence(s)

AL732557

UniProtKB/Swiss-Prot

O09114, O09157, O35091, Q3V2G5, Q62169
NM_001420746.1 → NP_001407675.1 prostaglandin-H2 D-isomerase precursor

Status: VALIDATED

Source sequence(s)

AL732557

UniProtKB/Swiss-Prot

O09114, O09157, O35091, Q3V2G5, Q62169
NM_008963.3 → NP_032989.2 prostaglandin-H2 D-isomerase precursor

See identical proteins and their annotated locations for NP_032989.2

Status: VALIDATED

Source sequence(s)

AL732557

Consensus CDS

CCDS38074.1

UniProtKB/Swiss-Prot

O09114, O09157, O35091, Q3V2G5, Q62169

Related

ENSMUSP00000015234.7, ENSMUST00000015234.13

Conserved Domains (1) summary

cd19419
Location:30 → 188

lipocalin_L-PGDS; lipocalin-type prostaglandin D synthase