Prl3d3 prolactin family 3, subfamily d, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prl3d3provided by MGI
Official Full Name: prolactin family 3, subfamily d, member 3provided by MGI
Primary source: MGI:MGI:2660938
See related: Ensembl:ENSMUSG00000062201 AllianceGenome:MGI:2660938
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ghd6; Plig; PL-Ig
Summary: Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including positive regulation of lactation; positive regulation of pri-miRNA transcription by RNA polymerase II; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be active in extracellular space. Is expressed in ectoplacental cone; extraembryonic component; and placenta. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward placenta adult (RPKM 11.2) See more
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Genomic context

Location:: 13 A3.1; 13 12.3 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (27340777..27346576)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (27156794..27162593)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that endogenous levels of Pkig reciprocally regulate osteoblast and adipocyte differentiation and that this reciprocal regulation is mediated in part by LIF.
Title: Protein kinase inhibitor γ reciprocally regulates osteoblast and adipocyte differentiation by downregulating leukemia inhibitory factor.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

Prl3d1 (e-PCR), detects polymorphism
- UniSTS:532243

NoName (e-PCR)
- UniSTS:491801

Prl3d1 (e-PCR), detects polymorphism
- UniSTS:531486

AI325057 (e-PCR)
- UniSTS:185969

Prl3d1 (e-PCR), detects polymorphism
- UniSTS:508553

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables prolactin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables prolactin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in female pregnancy	IBA Inferred from Biological aspect of Ancestor more info
involved_in mammary gland development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of lactation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to nutrient levels	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prolactin family 3, subfamily d, member 3

Names: PL-1 gamma; growth hormone d6; placental lactogen I gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001361097.1 → NP_001348026.1 prolactin family 3, subfamily d, member 3 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

BC068253, CN691496, LM644173

Consensus CDS

CCDS88430.1

UniProtKB/TrEMBL

A0A0M6L0J6, Q8CGZ6

Related

ENSMUSP00000153035.2, ENSMUST00000223958.2

Conserved Domains (1) summary

cd10288
Location:25 → 224

prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones
NM_172156.3 → NP_742168.1 prolactin family 3, subfamily d, member 3 isoform 1 precursor

See identical proteins and their annotated locations for NP_742168.1

Status: VALIDATED

Source sequence(s)

AL589679, BC068253, CN691496

Consensus CDS

CCDS26391.1

UniProtKB/TrEMBL

Q8CGZ6, Q8CGZ7

Related

ENSMUSP00000073286.4, ENSMUST00000073601.5

Conserved Domains (1) summary

cd10288
Location:24 → 223

prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones