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    Dazap1 DAZ associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 70248, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Dazap1provided by MGI
    Official Full Name
    DAZ associated protein 1provided by MGI
    Primary source
    MGI:MGI:1917498
    See related
    Ensembl:ENSMUSG00000069565 AllianceGenome:MGI:1917498
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mPrrp; 2410042M16Rik
    Summary
    Enables RNA stem-loop binding activity. Acts upstream of or within several processes, including maternal placenta development; positive regulation of mRNA splicing, via spliceosome; and spermatogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human DAZAP1 (DAZ associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 42.4), duodenum adult (RPKM 40.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C1; 10 39.72 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80097168..80124242)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80261362..80288408)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA asparagine 7 (anticodon GTT) Neighboring gene NADH:ubiquinone oxidoreductase core subunit S7 Neighboring gene STARR-positive B cell enhancer ABC_E5153 Neighboring gene STARR-positive B cell enhancer ABC_E10627 Neighboring gene guanidinoacetate methyltransferase Neighboring gene microRNA 6911 Neighboring gene predicted gene 15122 Neighboring gene STARR-positive B cell enhancer ABC_E5154 Neighboring gene ribosomal protein S15 Neighboring gene APC regulator of WNT signaling pathway 2 Neighboring gene STARR-positive B cell enhancer ABC_E8347 Neighboring gene RIKEN cDNA 2310011J03 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DAZAP1 regulates the splicing of Crem, Crisp2 and Pot1a transcripts. Chen HY, et al. Nucleic Acids Res, 2013 Nov. PMID 23965306, Free PMC Article
    2. Differential translation of Dazap1 transcripts during spermatogenesis. Yang CK, et al. PLoS One, 2013. PMID 23658607, Free PMC Article
    3. DAZAP1, an hnRNP protein, is required for normal growth and spermatogenesis in mice. Hsu LC, et al. RNA, 2008 Sep. PMID 18669443, Free PMC Article
    4. Dynamic changes in intranuclear and subcellular localizations of mouse Prrp/DAZAP1 during spermatogenesis: the necessity of the C-terminal proline-rich region for nuclear import and localization. Kurihara Y, et al. Arch Histol Cytol, 2004 Nov. PMID 15700540
    5. The RNA ligands for mouse proline-rich RNA-binding protein (mouse Prrp) contain two consensus sequences in separate loop structure. Hori T, et al. Nucleic Acids Res, 2005. PMID 15647502, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of Crem, Crisp2 and Pot1a as the natural substrates of DAZAP1 and show that DAZAP1 promotes the inclusion of specific exons in these genes.
      Title: DAZAP1 regulates the splicing of Crem, Crisp2 and Pot1a transcripts.
    2. The translation of the two Dazap1 transcripts is differentially regulated during spermatogenesis.
      Title: Differential translation of Dazap1 transcripts during spermatogenesis.
    3. DAZAP1 is not only essential for spermatogenesis, but also required for the normal growth and development of mice.
      Title: DAZAP1, an hnRNP protein, is required for normal growth and spermatogenesis in mice.
    4. Dynamic changes in intranuclear and subcellular localizations of DAZAP1 during spermatogenesis have been studied.
      Title: Dynamic changes in intranuclear and subcellular localizations of mouse Prrp/DAZAP1 during spermatogenesis: the necessity of the C-terminal proline-rich region for nuclear import and localization.
    5. Identification of RNA consensus sequences required for binding to DAZAP1.
      Title: The RNA ligands for mouse proline-rich RNA-binding protein (mouse Prrp) contain two consensus sequences in separate loop structure.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables RNA stem-loop binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(G) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(G) binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maternal placenta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DAZ-associated protein 1
    Names
    deleted in azoospermia-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122604.2 → NP_001116076.1  DAZ-associated protein 1 isoform b

      See identical proteins and their annotated locations for NP_001116076.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the 5' coding region, compared to variant 1. The resulting isoform (b) has an additional aa in the N-terminal region, compared to isoform a.
      Source sequence(s)
      AC140229
      Consensus CDS
      CCDS48626.1
      UniProtKB/Swiss-Prot
      Q9JII5
      UniProtKB/TrEMBL
      Q3U878
      Related
      ENSMUSP00000089958.6, ENSMUST00000092305.6
      Conserved Domains (2) summary
      cd12327
      Location:111 → 190
      RRM2_DAZAP1; RNA recognition motif 2 (RRM2) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:11 → 92
      RRM1_DAZAP1; RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

    2. NM_001122605.2 → NP_001116077.1  DAZ-associated protein 1 isoform c

      See identical proteins and their annotated locations for NP_001116077.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (c) has an additional aa in the C-terminal region, compared to isoform a.
      Source sequence(s)
      AC140229
      Consensus CDS
      CCDS48627.1
      UniProtKB/TrEMBL
      Q3U878, Q3UGB5
      Related
      ENSMUSP00000101000.4, ENSMUST00000105361.10
      Conserved Domains (2) summary
      cd12327
      Location:110 → 189
      RRM2_DAZAP1; RNA recognition motif 2 (RRM2) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:11 → 92
      RRM1_DAZAP1; RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

    3. NM_001378995.1 → NP_001365924.1  DAZ-associated protein 1 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (d).
      Source sequence(s)
      AC140229
      UniProtKB/TrEMBL
      Q3U878
      Conserved Domains (2) summary
      cd12327
      Location:111 → 190
      RRM2_DAZAP1; RNA recognition motif 2 (RRM2) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:11 → 92
      RRM1_DAZAP1; RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

    4. NM_133188.3 → NP_573451.2  DAZ-associated protein 1 isoform a

      See identical proteins and their annotated locations for NP_573451.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AC140229
      Consensus CDS
      CCDS35977.1
      UniProtKB/TrEMBL
      Q3U878
      Related
      ENSMUSP00000101001.2, ENSMUST00000105362.8
      Conserved Domains (2) summary
      cd12327
      Location:110 → 189
      RRM2_DAZAP1; RNA recognition motif 2 (RRM2) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:11 → 92
      RRM1_DAZAP1; RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

    RNA

    1. NR_166396.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC140229

    2. NR_166397.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC140229

    3. NR_166398.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC140229

    4. NR_166399.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC140229

    5. NR_166400.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC140229

    6. NR_166401.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC140229

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80097168..80124242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245259.2 → XP_030101119.1  DAZ-associated protein 1 isoform X4

      UniProtKB/TrEMBL
      Q3U878
      Conserved Domains (2) summary
      cd12327
      Location:102 → 181
      RRM2_DAZAP1; RNA recognition motif 2 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:3 → 84
      RRM1_DAZAP1; RNA recognition motif 1 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

    2. XM_006514070.5 → XP_006514133.1  DAZ-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      Q3U878
      Conserved Domains (2) summary
      cd12327
      Location:103 → 182
      RRM2_DAZAP1; RNA recognition motif 2 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:3 → 84
      RRM1_DAZAP1; RNA recognition motif 1 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

    3. XM_030245258.2 → XP_030101118.1  DAZ-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      Q3U878
      Conserved Domains (2) summary
      cd12327
      Location:103 → 182
      RRM2_DAZAP1; RNA recognition motif 2 (RRM2) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:3 → 84
      RRM1_DAZAP1; RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

    4. XM_006514071.4 → XP_006514134.1  DAZ-associated protein 1 isoform X3

      UniProtKB/TrEMBL
      Q3U878
      Conserved Domains (2) summary
      cd12327
      Location:102 → 181
      RRM2_DAZAP1; RNA recognition motif 2 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:3 → 84
      RRM1_DAZAP1; RNA recognition motif 1 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

    5. XM_036155992.1 → XP_036011885.1  DAZ-associated protein 1 isoform X5

      Conserved Domains (1) summary
      cl17169
      Location:1 → 47
      RRM_SF; RNA recognition motif (RRM) superfamily

    6. XM_006514072.5 → XP_006514135.1  DAZ-associated protein 1 isoform X5

      Conserved Domains (1) summary
      cl17169
      Location:1 → 47
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JII5.2 GenPept UniProtKB/Swiss-Prot:Q9JII5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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