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    Rab3il1 RAB3A interacting protein (rabin3)-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 74760, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rab3il1provided by MGI
    Official Full Name
    RAB3A interacting protein (rabin3)-like 1provided by MGI
    Primary source
    MGI:MGI:1922010
    See related
    Ensembl:ENSMUSG00000024663 AllianceGenome:MGI:1922010
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rab3ail1; 1200014K04Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity; identical protein binding activity; and kinase binding activity. Predicted to be involved in exocytosis. Predicted to act upstream of or within protein transport. Predicted to be active in Golgi to plasma membrane transport vesicle. Is expressed in embryo. Orthologous to human RAB3IL1 (RAB3A interacting protein like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 100.1), liver E14.5 (RPKM 29.4) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 A; 19 6.26 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (9979033..10015744)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10001669..10038380)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36913 Neighboring gene ferritin heavy polypeptide 1 Neighboring gene STARR-positive B cell enhancer mm9_chr19:10074872-10075172 Neighboring gene bestrophin 1 Neighboring gene fatty acid desaturase 3 Neighboring gene predicted gene, 29917 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10138709-10138947 Neighboring gene fatty acid desaturase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Grab regulates transferrin receptor recycling and iron uptake in developing erythroblasts. Chen M, et al. Blood, 2022 Sep 8. PMID 35820059
    2. GRAB is a binding partner for the Rab11a and Rab11b GTPases. Horgan CP, et al. Biochem Biophys Res Commun, 2013 Nov 8. PMID 24140058
    3. A Phosphoproteomic Screen Identifies a Guanine Nucleotide Exchange Factor for Rab3A Protein as a Mitogen-activated Protein (MAP) Kinase Phosphatase-5-regulated MAP Kinase Target in Interleukin 6 (IL-6) Secretion and Myogenesis. Lee H, et al. J Biol Chem, 2017 Mar 3. PMID 28096466, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Grab regulates transferrin receptor recycling and iron uptake in developing erythroblasts.
      Title: Grab regulates transferrin receptor recycling and iron uptake in developing erythroblasts.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi to plasma membrane transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide exchange factor for Rab-3A
    Names
    guanine nucleotide exchange factor for Rab3A
    rab-3A-interacting-like protein 1
    rab3A-interacting-like protein 1
    rabin3-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347429.1 → NP_001334358.1  guanine nucleotide exchange factor for Rab-3A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134437, AK161298
      Consensus CDS
      CCDS84417.1
      UniProtKB/Swiss-Prot
      Q8VDV3
      Related
      ENSMUSP00000113828.2, ENSMUST00000121418.8
      Conserved Domains (2) summary
      pfam06428
      Location:23 → 91
      Sec2p; GDP/GTP exchange factor Sec2p
      cl41767
      Location:148 → 310
      Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

    2. NM_001347430.1 → NP_001334359.1  guanine nucleotide exchange factor for Rab-3A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC134437, AK004767
      Consensus CDS
      CCDS84416.1
      UniProtKB/TrEMBL
      D3Z585
      Related
      ENSMUSP00000113551.2, ENSMUST00000117641.8

    3. NM_001378857.1 → NP_001365786.1  guanine nucleotide exchange factor for Rab-3A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134437
      Conserved Domains (2) summary
      pfam06428
      Location:23 → 91
      Sec2p; GDP/GTP exchange factor Sec2p
      cl41767
      Location:148 → 310
      Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

    4. NM_001378858.1 → NP_001365787.1  guanine nucleotide exchange factor for Rab-3A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134437
      Conserved Domains (2) summary
      pfam06428
      Location:23 → 91
      Sec2p; GDP/GTP exchange factor Sec2p
      cl41767
      Location:148 → 310
      Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

    5. NM_001378859.1 → NP_001365788.1  guanine nucleotide exchange factor for Rab-3A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC134437
      UniProtKB/TrEMBL
      A0A571BDP7
      Related
      ENSMUSP00000158807.2, ENSMUST00000238672.2
      Conserved Domains (2) summary
      pfam06428
      Location:92 → 160
      Sec2p; GDP/GTP exchange factor Sec2p
      cl41767
      Location:267 → 428
      Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

    6. NM_001378860.1 → NP_001365789.1  guanine nucleotide exchange factor for Rab-3A isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC134437
      Conserved Domains (2) summary
      pfam06428
      Location:139 → 190
      Sec2p; GDP/GTP exchange factor Sec2p
      cl41767
      Location:194 → 353
      Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

    7. NM_001378861.1 → NP_001365790.1  guanine nucleotide exchange factor for Rab-3A isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC134437
      Conserved Domains (2) summary
      pfam06428
      Location:23 → 73
      Sec2p; GDP/GTP exchange factor Sec2p
      cl41767
      Location:78 → 237
      Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

    8. NM_144538.3 → NP_653121.1  guanine nucleotide exchange factor for Rab-3A isoform 1

      See identical proteins and their annotated locations for NP_653121.1

      Status: VALIDATED

      Source sequence(s)
      AC134437, AK161298, BB733894
      Consensus CDS
      CCDS29569.1
      UniProtKB/Swiss-Prot
      Q3TTM0, Q8VDV3
      Related
      ENSMUSP00000108786.3, ENSMUST00000113161.10
      Conserved Domains (1) summary
      pfam06428
      Location:92 → 160
      Sec2p; GDP/GTP exchange factor Sec2p

    RNA

    1. NR_153790.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC134437

    2. NR_166144.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC134437

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      9979033..10015744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161717.1 → XP_036017610.1  guanine nucleotide exchange factor for Rab-3A isoform X6

      Conserved Domains (2) summary
      pfam06428
      Location:139 → 190
      Sec2p; GDP/GTP exchange factor Sec2p
      cl41767
      Location:194 → 353
      Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

    2. XM_030251119.1 → XP_030106979.1  guanine nucleotide exchange factor for Rab-3A isoform X5

      Conserved Domains (1) summary
      pfam06428
      Location:23 → 91
      Sec2p; GDP/GTP exchange factor Sec2p

    3. XM_030251123.1 → XP_030106983.1  guanine nucleotide exchange factor for Rab-3A isoform X7

      Conserved Domains (2) summary
      pfam06428
      Location:23 → 91
      Sec2p; GDP/GTP exchange factor Sec2p
      cl41767
      Location:148 → 310
      Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

    4. XM_006527414.1 → XP_006527477.1  guanine nucleotide exchange factor for Rab-3A isoform X2

      Conserved Domains (2) summary
      pfam06428
      Location:98 → 166
      Sec2p; GDP/GTP exchange factor Sec2p
      pfam16046
      Location:30 → 164
      FAM76; FAM76 protein

    5. XM_036161716.1 → XP_036017609.1  guanine nucleotide exchange factor for Rab-3A isoform X4

      Conserved Domains (2) summary
      pfam06428
      Location:98 → 166
      Sec2p; GDP/GTP exchange factor Sec2p
      cl41767
      Location:223 → 385
      Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

    6. XM_030251120.2 → XP_030106980.1  guanine nucleotide exchange factor for Rab-3A isoform X5

      Conserved Domains (1) summary
      pfam06428
      Location:23 → 91
      Sec2p; GDP/GTP exchange factor Sec2p

    7. XM_006527412.1 → XP_006527475.1  guanine nucleotide exchange factor for Rab-3A isoform X1

      Conserved Domains (2) summary
      pfam06428
      Location:139 → 207
      Sec2p; GDP/GTP exchange factor Sec2p
      pfam16046
      Location:71 → 205
      FAM76; FAM76 protein

    8. XM_036161715.1 → XP_036017608.1  guanine nucleotide exchange factor for Rab-3A isoform X3

      UniProtKB/TrEMBL
      D3YZ86
      Related
      ENSMUSP00000120401.3, ENSMUST00000149967.9
      Conserved Domains (2) summary
      pfam06428
      Location:139 → 207
      Sec2p; GDP/GTP exchange factor Sec2p
      cl41767
      Location:264 → 426
      Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

    9. XM_011247385.4 → XP_011245687.1  guanine nucleotide exchange factor for Rab-3A isoform X5

      Conserved Domains (1) summary
      pfam06428
      Location:23 → 91
      Sec2p; GDP/GTP exchange factor Sec2p

    RNA

    1. XR_877692.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDV3.1 GenPept UniProtKB/Swiss-Prot:Q8VDV3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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