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    Airim AFG2 interacting ribosome maturation factor [ Mus musculus (house mouse) ]

    Gene ID: 194268, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Airimprovided by MGI
    Official Full Name
    AFG2 interacting ribosome maturation factorprovided by MGI
    Primary source
    MGI:MGI:3041172
    See related
    Ensembl:ENSMUSG00000044730 AllianceGenome:MGI:3041172
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C1orf109; 9930104L06Rik
    Summary
    Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human C1orf109 (chromosome 1 open reading frame 109). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.8), limb E14.5 (RPKM 5.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D2.2; 4 57.94 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124830777..124838454)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (124936984..124944661)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700125G02 gene Neighboring gene Eph receptor A10 Neighboring gene cell division cycle associated 8 Neighboring gene STARR-positive B cell enhancer ABC_E424 Neighboring gene STARR-positive B cell enhancer ABC_E4665 Neighboring gene predicted gene 12930 Neighboring gene predicted gene, 32371 Neighboring gene R-spondin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107426

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in ribosomal large subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    AFG2-interacting ribosome maturation factor
    Names
    ribosome biogenesis protein C1orf109 homolog
    uncharacterized protein C1orf109 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355603.1 → NP_001342532.1  AFG2-interacting ribosome maturation factor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK037053, AK158126, AL606933, BY781867
      Consensus CDS
      CCDS89826.1
      UniProtKB/Swiss-Prot
      Q148T1, Q3TU44, Q499E6, Q8BI05
      Conserved Domains (1) summary
      pfam15011
      Location:13 → 167
      CK2S; Casein Kinase 2 substrate

    2. NM_001355605.1 → NP_001342534.1  AFG2-interacting ribosome maturation factor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK037053, AK158126, AL606933, BY781867
      Consensus CDS
      CCDS89826.1
      UniProtKB/Swiss-Prot
      Q148T1, Q3TU44, Q499E6, Q8BI05
      Conserved Domains (1) summary
      pfam15011
      Location:13 → 167
      CK2S; Casein Kinase 2 substrate

    3. NM_177573.3 → NP_808241.2  AFG2-interacting ribosome maturation factor

      See identical proteins and their annotated locations for NP_808241.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK158126, AL606933
      Consensus CDS
      CCDS89826.1
      UniProtKB/Swiss-Prot
      Q148T1, Q3TU44, Q499E6, Q8BI05
      Related
      ENSMUSP00000154851.2, ENSMUST00000094769.13
      Conserved Domains (1) summary
      pfam15011
      Location:13 → 167
      CK2S; Casein Kinase 2 substrate

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      124830777..124838454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502884.4 → XP_006502947.1  AFG2-interacting ribosome maturation factor isoform X1

      See identical proteins and their annotated locations for XP_006502947.1

      Conserved Domains (1) summary
      pfam15011
      Location:13 → 167
      CK2S; Casein Kinase 2 substrate

    2. XM_006502885.3 → XP_006502948.1  AFG2-interacting ribosome maturation factor isoform X1

      See identical proteins and their annotated locations for XP_006502948.1

      Conserved Domains (1) summary
      pfam15011
      Location:13 → 167
      CK2S; Casein Kinase 2 substrate
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q499E6.1 GenPept UniProtKB/Swiss-Prot:Q499E6

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