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    Ykt6 YKT6 v-SNARE homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 56418, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ykt6provided by MGI
    Official Full Name
    YKT6 v-SNARE homolog (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1927550
    See related
    Ensembl:ENSMUSG00000002741 AllianceGenome:MGI:1927550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610042I15Rik; 1810013M05Rik
    Summary
    Predicted to enable SNAP receptor activity and protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; retrograde transport, endosome to Golgi; and vesicle docking involved in exocytosis. Predicted to act upstream of or within protein transport and vesicle-mediated transport. Predicted to be located in several cellular components, including Golgi apparatus; dendrite; and neuronal cell body. Predicted to be integral component of plasma membrane. Predicted to be part of SNARE complex. Is expressed in coelomic epithelium of testis; embryo; and ovary. Orthologous to human YKT6 (YKT6 v-SNARE homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 32.6), CNS E14 (RPKM 26.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 A1; 11 3.89 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (5905779..5917780)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (5955758..5967780)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11967 Neighboring gene glucokinase Neighboring gene STARR-seq mESC enhancer starr_28446 Neighboring gene STARR-positive B cell enhancer ABC_E6947 Neighboring gene predicted gene, 53665 Neighboring gene calcium/calmodulin-dependent protein kinase II, beta Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:5900191-5900374 Neighboring gene STARR-positive B cell enhancer ABC_E11764 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:5917894-5918003 Neighboring gene NudC domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_28452 Neighboring gene ribosomal protein S15A, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi transport. McNew JA, et al. J Biol Chem, 1997 Jul 11. PMID 9211930
    2. Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport. Zhang T, et al. J Biol Chem, 2001 Jul 20. PMID 11323436
    3. Subtractive hybridisation screen identifies sexually dimorphic gene expression in the embryonic mouse gonad. McClive PJ, et al. Genesis, 2003 Oct. PMID 14595844
    4. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle docking involved in exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle docking involved in exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in vesicle targeting ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle targeting ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SNARE complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basal dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    synaptobrevin homolog YKT6
    Names
    YKT6 homolog
    prenylated SNARE protein (Ykt6)
    NP_062635.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019661.5 → NP_062635.2  synaptobrevin homolog YKT6

      See identical proteins and their annotated locations for NP_062635.2

      Status: VALIDATED

      Source sequence(s)
      AL645469
      Consensus CDS
      CCDS24410.1
      UniProtKB/Swiss-Prot
      O88595, Q9CQW1
      Related
      ENSMUSP00000002818.9, ENSMUST00000002818.9
      Conserved Domains (3) summary
      COG5143
      Location:3 → 198
      SNC1; Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]
      cd15867
      Location:136 → 195
      R-SNARE_YKT6; SNARE motif of YKT6
      pfam13774
      Location:44 → 107
      Longin; Regulated-SNARE-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      5905779..5917780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQW1.1 GenPept UniProtKB/Swiss-Prot:Q9CQW1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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