Slc2a5 solute carrier family 2 (facilitated glucose transporter), member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc2a5provided by MGI
Official Full Name: solute carrier family 2 (facilitated glucose transporter), member 5provided by MGI
Primary source: MGI:MGI:1928369
See related: Ensembl:ENSMUSG00000028976 AllianceGenome:MGI:1928369
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Glut5; Slc5a
Summary: Enables fructose transmembrane transporter activity. Involved in cellular response to fructose stimulus; fructose import across plasma membrane; and regulation of systemic arterial blood pressure mediated by a chemical signal. Located in apical plasma membrane. Is expressed in central nervous system and metanephros. Orthologous to human SLC2A5 (solute carrier family 2 member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 204.2), kidney adult (RPKM 46.2) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 80.97 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (150203801..150228625)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (150119344..150144168)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fructose promotes angiogenesis by improving vascular endothelial cell function and upregulating VEGF expression in cancer cells.
Title: Fructose promotes angiogenesis by improving vascular endothelial cell function and upregulating VEGF expression in cancer cells.
Analysis of glucose metabolism by (18)F-FDG-PET imaging and glucose transporter expression in a mouse model of intracerebral hemorrhage.
Title: Analysis of glucose metabolism by (18)F-FDG-PET imaging and glucose transporter expression in a mouse model of intracerebral hemorrhage.
GLUT5 is a determinant of dietary fructose-mediated exacerbation of experimental colitis.
Title: GLUT5 is a determinant of dietary fructose-mediated exacerbation of experimental colitis.
Identification of the fructose transporter GLUT5 (SLC2A5) as a novel target of nuclear receptor LXR.
Title: Identification of the fructose transporter GLUT5 (SLC2A5) as a novel target of nuclear receptor LXR.
identified amino acid residues of GLUT5 that define its substrate specificity for glucose transporter 5 (GLUT5)-mediated fructose transport.
Title: Identification of essential amino acids for glucose transporter 5 (GLUT5)-mediated fructose transport.
GLUT5 activity contributes to antipsychotic-induced weight gain.
Title: Dietary Fructose and GLUT5 Transporter Activity Contribute to Antipsychotic-Induced Weight Gain.
Feedforward upregulation of fructolytic and gluconeogenic enzymes specifically requires GLUT5 and KHK and may proactively enhance the intestine's ability to process anticipated increases in dietary fructose concentrations.
Title: Fructose-induced increases in expression of intestinal fructolytic and gluconeogenic genes are regulated by GLUT5 and KHK.
Significant levels of blood fructose are maintained independent of dietary fructose, KHK, and GLUT5, probably by endogenous synthesis of fructose.
Title: Effect of dietary fructose on portal and systemic serum fructose levels in rats and in KHK-/- and GLUT5-/- mice.
Fructose and GluT5 play an important role in regulating adipose differentiation.
Title: Regulation of adipose differentiation by fructose and GluT5.
regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents
Title: Positive regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5M4Mit14 (e-PCR)
- UniSTS:129915

D4Mit14 (e-PCR), detects polymorphism
- UniSTS:129915

RH136598 (e-PCR)
- UniSTS:210578

AI526984 (e-PCR)
- UniSTS:164274

Slc2a5 (e-PCR), detects polymorphism
- UniSTS:546003

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fructose binding	ISO Inferred from Sequence Orthology more info
enables fructose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructose transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables fructose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate transport	IEA Inferred from Electronic Annotation more info
involved_in cellular response to fructose stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to fructose stimulus	ISO Inferred from Sequence Orthology more info
involved_in fructose import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fructose import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in fructose transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of systemic arterial blood pressure mediated by a chemical signal	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to fructose	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 5

Names: GLUT-5; fructose transporter; glucose transporter type 5, small intestine

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019741.3 → NP_062715.2 solute carrier family 2, facilitated glucose transporter member 5

See identical proteins and their annotated locations for NP_062715.2

Status: PROVISIONAL

Source sequence(s)

AK029720

Consensus CDS

CCDS18968.1

UniProtKB/Swiss-Prot

Q8R1N7, Q9WV38

Related

ENSMUSP00000030826.3, ENSMUST00000030826.4

Conserved Domains (1) summary

cd17432
Location:22 → 470

MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

150203801..150228625

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539076.5 → XP_006539139.1 solute carrier family 2, facilitated glucose transporter member 5 isoform X1

See identical proteins and their annotated locations for XP_006539139.1

UniProtKB/Swiss-Prot

Q8R1N7, Q9WV38

Conserved Domains (1) summary

cd17432
Location:22 → 470

MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily