Fblim1 filamin binding LIM protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fblim1provided by MGI
Official Full Name: filamin binding LIM protein 1provided by MGI
Primary source: MGI:MGI:1921452
See related: Ensembl:ENSMUSG00000006219 AllianceGenome:MGI:1921452
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cal; Gt10; Fblp1; migfilin; migfilin(s); 2410043F08Rik
Summary: Predicted to enable filamin binding activity. Predicted to be involved in cell-cell adhesion and regulation of integrin activation. Predicted to act upstream of or within cell adhesion and regulation of cell shape. Predicted to be located in several cellular components, including cell junction; cell periphery; and fibrillar center. Predicted to be active in focal adhesion and stress fiber. Is expressed in several structures, including central nervous system; early conceptus; reproductive system; sensory organ; and urinary system. Orthologous to human FBLIM1 (filamin binding LIM protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in heart adult (RPKM 66.2), bladder adult (RPKM 34.1) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 74.64 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (141303373..141333351, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (141576062..141606052, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings indicate that tightly regulated expression of migfilin is essential for neuronal development and that FBLIM1 disruption may be related to the phenotypes associated with ASD and related neurodevelopmental disorders.
Title: Possible involvement of a cell adhesion molecule, Migfilin, in brain development and pathogenesis of autism spectrum disorders.
Suggest migfilin regulates cardiac hypertrophy in transverse aortic constriction.
Title: In vivo cardiac role of migfilin during experimental pressure overload.
C-terminal LIM domains of migfilin dictate its focal adhesion localization, and these domains mediate an interaction with kindlin in vitro and in cells, demonstrating that kindlin is important for normal migfilin dynamics.
Title: Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics.
results identify FBLP-1 as a key regulator of bone homeostasis and suggest that FBLP-1 functions in this process through modulating both the intrinsic properties of OB/BMSCs (i.e., BMSC-extracellular matrix adhesion and migration
Title: Critical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling.
This study demonistrated that a molecular mechanism whereby FlnA loss impaired G2 to M phase entry, leading to cell cycle prolongation, compromised neural progenitor proliferation, and reduced brain size.
Title: Filamin a regulates neural progenitor proliferation and cortical size through Wee1-dependent Cdk1 phosphorylation.
The findings indicate that the roles of migfilin are functionally redundant during mouse development and tissue homeostasis.
Title: Loss of migfilin expression has no overt consequences on murine development and homeostasis.
analysis of the migfilin-filamin interaction and competition with integrin beta 7 tails
Title: Structural basis of the migfilin-filamin interaction and competition with integrin beta tails.
results suggest that a novel LIM protein Cal induces cardiomyocyte differentiation through its dynamic intracellular shuttling and association with CSX/NKX2-5
Title: A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (4)
Targeted (3) 1 citation
Endonuclease-mediated (7)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D4Mit284 (e-PCR), detects polymorphism
- UniSTS:130075

NoName (e-PCR)
- UniSTS:235082

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables filamin binding	IBA Inferred from Biological aspect of Ancestor more info
enables filamin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in regulation of integrin activation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
is_active_in stress fiber	IBA Inferred from Biological aspect of Ancestor more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: filamin-binding LIM protein 1

Names: CSX-associated LIM; FBLP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163256.2 → NP_001156728.1 filamin-binding LIM protein 1 isoform 1

See identical proteins and their annotated locations for NP_001156728.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AL670446

Consensus CDS

CCDS18876.1

UniProtKB/Swiss-Prot

Q3TDK3, Q71FD7, Q99J35

Related

ENSMUSP00000101410.2, ENSMUST00000105784.8

Conserved Domains (3) summary

cd09357
Location:305 → 366

LIM3_Zyxin_like; The third LIM domain of Zyxin-like family

cd09372
Location:245 → 297

LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)

cl02475
Location:181 → 238

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001378958.2 → NP_001365887.1 filamin-binding LIM protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL670446

UniProtKB/Swiss-Prot

Q3TDK3, Q71FD7, Q99J35

Conserved Domains (3) summary

cd09357
Location:305 → 366

LIM3_Zyxin_like; The third LIM domain of Zyxin-like family

cd09372
Location:245 → 297

LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)

cl02475
Location:181 → 238

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001378959.1 → NP_001365888.1 filamin-binding LIM protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL670446

UniProtKB/Swiss-Prot

Q3TDK3, Q71FD7, Q99J35

Related

ENSMUSP00000006381.5, ENSMUST00000006381.11

Conserved Domains (3) summary

cd09357
Location:305 → 366

LIM3_Zyxin_like; The third LIM domain of Zyxin-like family

cd09372
Location:245 → 297

LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)

cl02475
Location:181 → 238

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001404640.1 → NP_001391569.1 filamin-binding LIM protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL670446

UniProtKB/Swiss-Prot

Q3TDK3, Q71FD7, Q99J35
NM_001404641.1 → NP_001391570.1 filamin-binding LIM protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL670446

UniProtKB/Swiss-Prot

Q3TDK3, Q71FD7, Q99J35
NM_001404642.1 → NP_001391571.1 filamin-binding LIM protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL670446
NM_001404643.1 → NP_001391572.1 filamin-binding LIM protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL670446

UniProtKB/Swiss-Prot

Q3TDK3, Q71FD7, Q99J35
NM_001404644.1 → NP_001391573.1 filamin-binding LIM protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL670446

UniProtKB/Swiss-Prot

Q3TDK3, Q71FD7, Q99J35
NM_133754.6 → NP_598515.3 filamin-binding LIM protein 1 isoform 1

See identical proteins and their annotated locations for NP_598515.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AL670446

Consensus CDS

CCDS18876.1

UniProtKB/Swiss-Prot

Q3TDK3, Q71FD7, Q99J35

Related

ENSMUSP00000101411.3, ENSMUST00000105785.9

Conserved Domains (3) summary

cd09357
Location:305 → 366

LIM3_Zyxin_like; The third LIM domain of Zyxin-like family

cd09372
Location:245 → 297

LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)

cl02475
Location:181 → 238

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

141303373..141333351 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539215.4 → XP_006539278.1 filamin-binding LIM protein 1 isoform X2

See identical proteins and their annotated locations for XP_006539278.1

UniProtKB/Swiss-Prot

Q3TDK3, Q71FD7, Q99J35

Conserved Domains (3) summary

cd09357
Location:305 → 366

LIM3_Zyxin_like; The third LIM domain of Zyxin-like family

cd09372
Location:245 → 297

LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)

cl02475
Location:181 → 238

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_006539214.4 → XP_006539277.1 filamin-binding LIM protein 1 isoform X2

See identical proteins and their annotated locations for XP_006539277.1

UniProtKB/Swiss-Prot

Q3TDK3, Q71FD7, Q99J35

Conserved Domains (3) summary

cd09357
Location:305 → 366

LIM3_Zyxin_like; The third LIM domain of Zyxin-like family

cd09372
Location:245 → 297

LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)

cl02475
Location:181 → 238

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_030253841.1 → XP_030109701.1 filamin-binding LIM protein 1 isoform X2

UniProtKB/Swiss-Prot

Q3TDK3, Q71FD7, Q99J35

Conserved Domains (3) summary

cd09357
Location:305 → 366

LIM3_Zyxin_like; The third LIM domain of Zyxin-like family

cd09372
Location:245 → 297

LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)

cl02475
Location:181 → 238

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers