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    Cdc42ep5 CDC42 effector protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 58804, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cdc42ep5provided by MGI
    Official Full Name
    CDC42 effector protein 5provided by MGI
    Primary source
    MGI:MGI:1929745
    See related
    Ensembl:ENSMUSG00000063838 AllianceGenome:MGI:1929745
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CEP5; Borg3; 1700027J19Rik; 2010007O02Rik
    Summary
    Predicted to enable small GTPase binding activity. Acts upstream of or within JNK cascade and Rho protein signal transduction. Located in cytoplasm and plasma membrane. Orthologous to human CDC42EP5 (CDC42 effector protein 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in duodenum adult (RPKM 230.1), colon adult (RPKM 182.6) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 A1; 7 2.4 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4154259..4167830, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4151260..4164831, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene leukocyte receptor cluster (LRC) member 8 Neighboring gene STARR-positive B cell enhancer ABC_E8149 Neighboring gene STARR-seq mESC enhancer starr_17920 Neighboring gene leukocyte receptor cluster (LRC) member 9 Neighboring gene calcium binding protein 39 pseudogene Neighboring gene STARR-seq mESC enhancer starr_17921 Neighboring gene STARR-seq mESC enhancer starr_17922 Neighboring gene leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion. Farrugia AJ, et al. J Cell Biol, 2020 Sep 7. PMID 32798219, Free PMC Article
    2. Borg proteins control septin organization and are negatively regulated by Cdc42. Joberty G, et al. Nat Cell Biol, 2001 Oct. PMID 11584266
    3. A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes. Hirsch DS, et al. J Biol Chem, 2001 Jan 12. PMID 11035016
    4. The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Joberty G, et al. Mol Cell Biol, 1999 Oct. PMID 10490598, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion.
      Title: CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117885

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of pseudopodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of pseudopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cdc42 effector protein 5
    Names
    CDC42 effector protein (Rho GTPase binding) 5
    CRIB-containing BORG3 protein
    binder of Rho GTPase 3
    binder of Rho GTPases 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021454.4 → NP_067429.1  cdc42 effector protein 5

      See identical proteins and their annotated locations for NP_067429.1

      Status: VALIDATED

      Source sequence(s)
      AC101941
      Consensus CDS
      CCDS20733.1
      UniProtKB/Swiss-Prot
      Q3SYK1, Q9QZT9, Q9Z0X0
      Related
      ENSMUSP00000092508.5, ENSMUST00000076831.7
      Conserved Domains (2) summary
      cl00113
      Location:23 → 49
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      pfam14957
      Location:85 → 110
      BORG_CEP; Cdc42 effector

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      4154259..4167830 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540250.4 → XP_006540313.1  cdc42 effector protein 5 isoform X2

      See identical proteins and their annotated locations for XP_006540313.1

      UniProtKB/Swiss-Prot
      Q3SYK1, Q9QZT9, Q9Z0X0
      Conserved Domains (2) summary
      cl00113
      Location:23 → 49
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      pfam14957
      Location:85 → 110
      BORG_CEP; Cdc42 effector

    2. XM_006540249.5 → XP_006540312.1  cdc42 effector protein 5 isoform X1

      Conserved Domains (2) summary
      cl00113
      Location:32 → 58
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      pfam14957
      Location:94 → 119
      BORG_CEP; Cdc42 effector
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0X0.2 GenPept UniProtKB/Swiss-Prot:Q9Z0X0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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