Slc25a33 solute carrier family 25, member 33 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc25a33provided by MGI
Official Full Name: solute carrier family 25, member 33provided by MGI
Primary source: MGI:MGI:1917806
See related: Ensembl:ENSMUSG00000028982 AllianceGenome:MGI:1917806
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pnc1; 5730438N18Rik
Summary: Predicted to enable pyrimidine nucleotide transmembrane transporter activity. Involved in mitochondria-nucleus signaling pathway; positive regulation of cell growth; and pyrimidine nucleotide import into mitochondrion. Located in mitochondrial membrane. Is expressed in brainstem; liver; nervous system; and retina outer nuclear layer. Orthologous to human SLC25A33 (solute carrier family 25 member 33). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 23.3), cerebellum adult (RPKM 18.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 80.15 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (149828493..149858746, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (149744036..149774267, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data indicate that PNC1 is a target of the IGF-I/mTOR pathway that is essential for mitochondrial activity in regulating cell growth and proliferation.
Title: The insulin-like growth factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc25a33 (e-PCR), detects polymorphism
- UniSTS:547049

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables pyrimidine nucleotide transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyrimidine nucleotide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin-like growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in mitochondria-nucleus signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial genome maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial genome maintenance	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex III assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial transcription	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine nucleotide import into mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyrimidine nucleotide import into mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyrimidine nucleotide import into mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine nucleotide transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of oxidative phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: solute carrier family 25 member 33

Names: mitochondrial carrier protein; novel mitochondrial carrier protein domains containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027460.2 → NP_081736.2 solute carrier family 25 member 33

See identical proteins and their annotated locations for NP_081736.2

Status: VALIDATED

Source sequence(s)

AW989568, BB772382, BG063566, BQ950692, CK795124

Consensus CDS

CCDS38976.1

UniProtKB/Swiss-Prot

Q3TZX3, Q921P8, Q9CYJ1

Related

ENSMUSP00000101311.3, ENSMUST00000105686.3

Conserved Domains (2) summary

PTZ00169
Location:6 → 316

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:7 → 123

Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

149828493..149858746 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164415.1 → XP_036020308.1 solute carrier family 25 member 33 isoform X2

Conserved Domains (1) summary

pfam00153
Location:62 → 149

Mito_carr; Mitochondrial carrier protein
XM_036164414.1 → XP_036020307.1 solute carrier family 25 member 33 isoform X1

Conserved Domains (1) summary

pfam00153
Location:65 → 152

Mito_carr; Mitochondrial carrier protein
XM_036164416.1 → XP_036020309.1 solute carrier family 25 member 33 isoform X2

Conserved Domains (1) summary

pfam00153
Location:62 → 149

Mito_carr; Mitochondrial carrier protein