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    Ces2g carboxylesterase 2G [ Mus musculus (house mouse) ]

    Gene ID: 72361, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Ces2gprovided by MGI
    Official Full Name
    carboxylesterase 2Gprovided by MGI
    Primary source
    MGI:MGI:1919611
    See related
    Ensembl:ENSMUSG00000031877 AllianceGenome:MGI:1919611
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ces2l; 2210023G05Rik
    Summary
    Predicted to enable carboxylic ester hydrolase activity. Predicted to be involved in prostaglandin metabolic process. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including central nervous system; foregut; liver; respiratory system; and sensory organ. Orthologous to human CES2 (carboxylesterase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in stomach adult (RPKM 17.0), duodenum adult (RPKM 16.6) and 17 other tissues See more
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    Genomic context

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    Location:
    8 D3; 8 53.04 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105688350..105696169)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (104961596..104969537)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene carboxylesterase 2E Neighboring gene carboxylesterase 2F Neighboring gene STARR-seq mESC enhancer starr_22518 Neighboring gene carboxylesterase 2E pseudogene Neighboring gene carboxylesterase 2H

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lipopolysaccharide suppresses carboxylesterase 2g activity and 2-arachidonoylglycerol hydrolysis: A possible mechanism to regulate inflammation. Szafran B, et al. Prostaglandins Other Lipid Mediat, 2015 Sep. PMID 26403860, Free PMC Article
    2. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, et al. Mamm Genome, 2010 Oct. PMID 20931200, Free PMC Article
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxylesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in prostaglandin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carboxylesterase 2-like
    NP_932116.2
    XP_006531455.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_197999.2 → NP_932116.2  carboxylesterase 2-like precursor

      Status: VALIDATED

      Source sequence(s)
      AC166833
      Consensus CDS
      CCDS22589.1
      UniProtKB/TrEMBL
      E9PV38, Q8R097
      Related
      ENSMUSP00000049315.8, ENSMUST00000043183.8
      Conserved Domains (2) summary
      COG0657
      Location:72 → 337
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:31 → 539
      COesterase; Carboxylesterase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      105688350..105696169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531392.1 → XP_006531455.1  carboxylesterase 2-like isoform X1

      Conserved Domains (1) summary
      cl21494
      Location:2 → 256
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version

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