Cpxm1 carboxypeptidase X, M14 family member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cpxm1provided by MGI
Official Full Name: carboxypeptidase X, M14 family member 1provided by MGI
Primary source: MGI:MGI:1934569
See related: Ensembl:ENSMUSG00000027408 AllianceGenome:MGI:1934569
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cpx1; Cpxm; Cpx-1
Summary: Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process and protein processing. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Orthologous to human CPXM1 (carboxypeptidase X, M14 family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 38.3), bladder adult (RPKM 32.5) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 63.22 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (130232695..130239549, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (130390775..130397629, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings establish CPX-1 as a positive regulator of adipogenesis situated downstream of FGF-1/BAMBI that may contribute to hyperplastic adipose tissue expansion via affecting extracellular matrix remodeling.
Title: Identification of carboxypeptidase X (CPX)-1 as a positive regulator of adipogenesis.
transient up-regulation pattern of CPX-1 expression may be important for the successful progression from pre-osteoclasts to mature osteoclasts.
Title: Elucidation of CPX-1 involvement in RANKL-induced osteoclastogenesis by a proteomics approach.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH131322 (e-PCR)
- UniSTS:214605

AA986902 (e-PCR)
- UniSTS:165211

Cpxm1 (e-PCR), detects polymorphism
- UniSTS:506817

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables carboxypeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallocarboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
NOT acts_upstream_of_or_within proteolysis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: probable carboxypeptidase X1

Names: carboxypeptidase X (M14 family); carboxypeptidase X 1 (M14 family); metallocarboxypeptidase 1; metallocarboxypeptidase CPX-1

NP_062670.2

EC 3.4.17.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019696.2 → NP_062670.2 probable carboxypeptidase X1 precursor

See identical proteins and their annotated locations for NP_062670.2

Status: VALIDATED

Source sequence(s)

AF077738, AK132611, BY282671

Consensus CDS

CCDS16740.1

UniProtKB/Swiss-Prot

A2BI86, Q99LA3, Q9Z100

Related

ENSMUSP00000028897.8, ENSMUST00000028897.8

Conserved Domains (4) summary

cd03869
Location:284 → 609

M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup

cd11308
Location:613 → 689

Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

smart00231
Location:107 → 263

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00057
Location:106 → 262

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.