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    ADGRG5 adhesion G protein-coupled receptor G5 [ Homo sapiens (human) ]

    Gene ID: 221188, updated on 11-Apr-2024

    Summary

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    Official Symbol
    ADGRG5provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor G5provided by HGNC
    Primary source
    HGNC:HGNC:19010
    See related
    Ensembl:ENSG00000159618 MIM:616965; AllianceGenome:HGNC:19010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGR27; GPR114
    Summary
    This gene encodes a member of the adhesion family of G-protein coupled receptors. Members of this family are characterized by long N-termini and multiple functional domains. They may play a role in the immune system as well as in the central nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
    Expression
    Biased expression in lymph node (RPKM 4.6), spleen (RPKM 3.3) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ADGRG5 in Genome Data Viewer
    Location:
    16q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (57529073..57577189)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (63324271..63372382)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57576555..57611101)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5957 Neighboring gene Sharpr-MPRA regulatory region 83 Neighboring gene coenzyme Q9 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57506902-57507423 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57507424-57507944 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57508610-57509398 Neighboring gene RNA polymerase II subunit C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57519658-57520454 Neighboring gene docking protein 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57541954-57542946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57543642-57544142 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43689 Neighboring gene coiled-coil domain containing 102A Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57562855-57563355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10897 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57566372-57566931 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57566932-57567490 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7531 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10899 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10900 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43712 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10901 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57598339-57598840 Neighboring gene uncharacterized LOC105371291 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43740 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7533 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7534 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10902 Neighboring gene uncharacterized LOC107984889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10903 Neighboring gene high mobility group box 3 pseudogene 32

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist. Wilde C, et al. FASEB J, 2016 Feb. PMID 26499266
    2. Genome-wide association study of vitamin D concentrations in Hispanic Americans: the IRAS family study. Engelman CD, et al. J Steroid Biochem Mol Biol, 2010 Oct. PMID 20600896, Free PMC Article
    3. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. Fredriksson R, et al. FEBS Lett, 2002 Nov 20. PMID 12435584
    4. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Bjarnadóttir TK, et al. Genomics, 2004 Jul. PMID 15203201
    5. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Hamann J, et al. Pharmacol Rev, 2015. PMID 25713288, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genome-wide association study of vitamin D concentrations in Hispanic Americans: the IRAS family study.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G-protein coupled receptor G5
    Names
    G protein-coupled receptor 114
    G protein-coupled receptor PGR27
    probable G-protein coupled receptor 114

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304376.3 → NP_001291305.1  adhesion G-protein coupled receptor G5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001291305.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK292783, AY358447, BC032401, BM193863
      Consensus CDS
      CCDS10785.1
      UniProtKB/Swiss-Prot
      A0A024R6S3, A8K9R8, B3KXZ5, Q6ZMH7, Q6ZML4, Q86SL8, Q8IZ14, Q8IZF4
      Related
      ENSP00000290823.4, ENST00000349457.8
      Conserved Domains (2) summary
      pfam01825
      Location:187 → 232
      GPS; GPCR proteolysis site, GPS, motif
      cd15443
      Location:245 → 518
      7tmB2_GPR114; orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G protein-coupled receptors

    2. NM_001318481.2 → NP_001305410.1  adhesion G-protein coupled receptor G5 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK292783, AK303661, AY140956, BC032401, BM193863
      UniProtKB/TrEMBL
      B4E148
      Conserved Domains (2) summary
      pfam01825
      Location:187 → 232
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:247 → 363
      7tm_4; Olfactory receptor

    3. NM_153837.4 → NP_722579.1  adhesion G-protein coupled receptor G5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_722579.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC004382, AK292783, AK303661, AY358447, BC032401, BM193863
      Consensus CDS
      CCDS10785.1
      UniProtKB/Swiss-Prot
      A0A024R6S3, A8K9R8, B3KXZ5, Q6ZMH7, Q6ZML4, Q86SL8, Q8IZ14, Q8IZF4
      Related
      ENSP00000342981.4, ENST00000340339.4
      Conserved Domains (2) summary
      pfam01825
      Location:187 → 232
      GPS; GPCR proteolysis site, GPS, motif
      cd15443
      Location:245 → 518
      7tmB2_GPR114; orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      57529073..57577189
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433776.1 → XP_047289732.1  adhesion G-protein coupled receptor G5 isoform X2

    2. XM_011522949.3 → XP_011521251.2  adhesion G-protein coupled receptor G5 isoform X1

    3. XM_047433778.1 → XP_047289734.1  adhesion G-protein coupled receptor G5 isoform X5

    4. XM_047433777.1 → XP_047289733.1  adhesion G-protein coupled receptor G5 isoform X3

    5. XM_011522950.3 → XP_011521252.1  adhesion G-protein coupled receptor G5 isoform X4

      See identical proteins and their annotated locations for XP_011521252.1

      UniProtKB/Swiss-Prot
      A0A024R6S3, A8K9R8, B3KXZ5, Q6ZMH7, Q6ZML4, Q86SL8, Q8IZ14, Q8IZF4
      Conserved Domains (2) summary
      pfam01825
      Location:187 → 232
      GPS; GPCR proteolysis site, GPS, motif
      cd15443
      Location:245 → 518
      7tmB2_GPR114; orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      63324271..63372382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379814.1 → XP_054235789.1  adhesion G-protein coupled receptor G5 isoform X2

    2. XM_054379813.1 → XP_054235788.1  adhesion G-protein coupled receptor G5 isoform X1

    3. XM_054379817.1 → XP_054235792.1  adhesion G-protein coupled receptor G5 isoform X5

    4. XM_054379815.1 → XP_054235790.1  adhesion G-protein coupled receptor G5 isoform X3

    5. XM_054379816.1 → XP_054235791.1  adhesion G-protein coupled receptor G5 isoform X4

      UniProtKB/Swiss-Prot
      A0A024R6S3, A8K9R8, B3KXZ5, Q6ZMH7, Q6ZML4, Q86SL8, Q8IZ14, Q8IZF4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IZF4.3 GenPept UniProtKB/Swiss-Prot:Q8IZF4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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