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    Nt5c2 5'-nucleotidase, cytosolic II [ Mus musculus (house mouse) ]

    Gene ID: 76952, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Nt5c2provided by MGI
    Official Full Name
    5'-nucleotidase, cytosolic IIprovided by MGI
    Primary source
    MGI:MGI:2178563
    See related
    Ensembl:ENSMUSG00000025041 AllianceGenome:MGI:2178563
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gmp; CnII; Nt5b; Pnt5; cN-II; Gm9751; 2010002I23Rik
    Summary
    Enables GMP 5'-nucleotidase activity. Involved in GMP catabolic process to guanine; allantoin metabolic process; and dGMP catabolic process. Located in cytosol. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 45. Orthologous to human NT5C2 (5'-nucleotidase, cytosolic II). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 17.2), CNS E14 (RPKM 14.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 C3; 19 38.97 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46873829..47003613, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46885390..47015174, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8753 Neighboring gene arsenite methyltransferase Neighboring gene cyclin M2 Neighboring gene STARR-seq mESC enhancer starr_46325 Neighboring gene STARR-seq mESC enhancer starr_46328 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:46962419-46962620 Neighboring gene DBF4 homolog pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11036 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:47044836-47045019 Neighboring gene STARR-seq mESC enhancer starr_46332 Neighboring gene STARR-seq mESC enhancer starr_46336 Neighboring gene lysophosphatidic acid receptor 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11037 Neighboring gene STARR-seq mESC enhancer starr_46338 Neighboring gene internexin neuronal intermediate filament protein, alpha Neighboring gene polycomb group ring finger 6 Neighboring gene predicted gene, 23140

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deoxyribonucleotide phosphatase from rat liver and cultured mouse fibroblasts. Magnusson G. Eur J Biochem, 1971 May 28. PMID 5560407
    2. Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia. Tzoneva G, et al. Nature, 2018 Jan 25. PMID 29342136, Free PMC Article
    3. Effects of genetic deletion of soluble 5'-nucleotidases NT5C1A and NT5C2 on AMPK activation and nucleotide levels in contracting mouse skeletal muscles. Kviklyte S, et al. Am J Physiol Endocrinol Metab, 2017 Jul 1. PMID 28325731
    4. Bovine cytosolic IMP/GMP-specific 5'-nucleotidase: cloning and expression of active enzyme in Escherichia coli. Allegrini S, et al. Biochem J, 1997 Dec 1. PMID 9371705, Free PMC Article
    5. Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein. Sala-Newby GB, et al. Biochim Biophys Acta, 2001 Oct 31. PMID 11690631

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results on muscles from the NT5C knockout mice contradict previous findings where AMP levels and AMPK activity were shown to be modulated by NT5C enzymes.
      Title: Effects of genetic deletion of soluble 5'-nucleotidases NT5C1A and NT5C2 on AMPK activation and nucleotide levels in contracting mouse skeletal muscles.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-nucleotidase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GMP 5'-nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GMP 5'-nucleotidase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables IMP 5'-nucleotidase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables XMP 5'-nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside phosphotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in GMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in GMP catabolic process to guanine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in GMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in IMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in IMP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in IMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenosine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenosine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in allantoin metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in allantoin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in amide catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in dGMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dGMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic purine 5'-nucleotidase
    Names
    cytosolic 5'-nucleotidase II
    cytosolic nucleoside phosphotransferase 5'N
    NP_001157835.1
    NP_001157837.1
    NP_001363995.1
    NP_001363997.1
    NP_001363998.1
    NP_001363999.1
    NP_084086.3
    XP_030106990.1
    XP_030106991.1
    XP_030106997.1
    XP_030107000.1
    XP_036017617.1
    XP_036017618.1
    XP_036017619.1
    XP_036017620.1
    XP_036017621.1
    XP_036017622.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164363.2 → NP_001157835.1  cytosolic purine 5'-nucleotidase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC108814, AC122442
      Consensus CDS
      CCDS50462.1
      UniProtKB/TrEMBL
      E9Q9M1
      Related
      ENSMUSP00000130898.3, ENSMUST00000172239.3
      Conserved Domains (1) summary
      pfam05761
      Location:69 → 514
      5_nucleotid; 5' nucleotidase family

    2. NM_001164365.2 → NP_001157837.1  cytosolic purine 5'-nucleotidase isoform 2

      See identical proteins and their annotated locations for NP_001157837.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC108814, AC122442
      Consensus CDS
      CCDS50461.1
      UniProtKB/TrEMBL
      A0A494B9X3
      Related
      ENSMUSP00000157802.2, ENSMUST00000235234.2
      Conserved Domains (1) summary
      pfam05761
      Location:68 → 513
      5_nucleotid; 5' nucleotidase family

    3. NM_001377066.1 → NP_001363995.1  cytosolic purine 5'-nucleotidase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 3, 6, and 7, encodes isoform 3.
      Source sequence(s)
      AC108814, AC122442
      UniProtKB/Swiss-Prot
      Q3V1L4, Q6P223, Q8BZ43, Q9D8G6
      Conserved Domains (1) summary
      pfam05761
      Location:43 → 488
      5_nucleotid; 5' nucleotidase family

    4. NM_001377068.1 → NP_001363997.1  cytosolic purine 5'-nucleotidase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 3, 5, and 7, encodes isoform 3.
      Source sequence(s)
      AC108814, AC122442
      UniProtKB/Swiss-Prot
      Q3V1L4, Q6P223, Q8BZ43, Q9D8G6
      Conserved Domains (1) summary
      pfam05761
      Location:43 → 488
      5_nucleotid; 5' nucleotidase family

    5. NM_001377069.1 → NP_001363998.1  cytosolic purine 5'-nucleotidase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 3, 5, and 6, encodes isoform 3.
      Source sequence(s)
      AC108814, AC122442
      UniProtKB/Swiss-Prot
      Q3V1L4, Q6P223, Q8BZ43, Q9D8G6
      Related
      ENSMUSP00000158280.2, ENSMUST00000236501.2
      Conserved Domains (1) summary
      pfam05761
      Location:43 → 488
      5_nucleotid; 5' nucleotidase family

    6. NM_001377070.1 → NP_001363999.1  cytosolic purine 5'-nucleotidase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
      Related
      ENSMUSP00000158576.2, ENSMUST00000236727.2
      Conserved Domains (1) summary
      pfam05761
      Location:14 → 459
      5_nucleotid; 5' nucleotidase family

    7. NM_029810.5 → NP_084086.3  cytosolic purine 5'-nucleotidase isoform 3

      See identical proteins and their annotated locations for NP_084086.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Variants 3 and 5-7 all encode the same isoform (3).
      Source sequence(s)
      AC108814, AC122442
      Consensus CDS
      CCDS29883.1
      UniProtKB/Swiss-Prot
      Q3V1L4, Q6P223, Q8BZ43, Q9D8G6
      Related
      ENSMUSP00000129126.2, ENSMUST00000168536.9
      Conserved Domains (1) summary
      pfam05761
      Location:43 → 488
      5_nucleotid; 5' nucleotidase family

    RNA

    1. NR_028353.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442

    2. NR_165058.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442

    3. NR_165059.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442

    4. NR_165060.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442

    5. NR_165061.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442

    6. NR_165062.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442

    7. NR_165063.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442

    8. NR_165064.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442

    9. NR_165065.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442

    10. NR_165066.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442

    11. NR_165067.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442

    12. NR_165068.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442

    13. NR_165069.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442

    14. NR_165070.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442

    15. NR_165071.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442

    16. NR_165072.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442

    17. NR_165073.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442

    18. NR_165074.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442

    19. NR_165075.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442

    20. NR_165076.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442

    21. NR_165253.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
      Related
      ENSMUST00000086961.15

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      46873829..47003613 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161729.1 → XP_036017622.1  cytosolic purine 5'-nucleotidase isoform X3

      Conserved Domains (1) summary
      cl17687
      Location:1 → 297
      5_nucleotid; 5' nucleotidase family

    2. XM_030251137.1 → XP_030106997.1  cytosolic purine 5'-nucleotidase isoform X3

      Conserved Domains (1) summary
      cl17687
      Location:1 → 297
      5_nucleotid; 5' nucleotidase family

    3. XM_036161725.1 → XP_036017618.1  cytosolic purine 5'-nucleotidase isoform X2

      Conserved Domains (1) summary
      pfam05761
      Location:55 → 357
      5_nucleotid; 5' nucleotidase family

    4. XM_036161727.1 → XP_036017620.1  cytosolic purine 5'-nucleotidase isoform X2

      Conserved Domains (1) summary
      pfam05761
      Location:55 → 357
      5_nucleotid; 5' nucleotidase family

    5. XM_030251130.2 → XP_030106990.1  cytosolic purine 5'-nucleotidase isoform X2

      Conserved Domains (1) summary
      pfam05761
      Location:55 → 357
      5_nucleotid; 5' nucleotidase family

    6. XM_030251140.2 → XP_030107000.1  cytosolic purine 5'-nucleotidase isoform X3

      Conserved Domains (1) summary
      cl17687
      Location:1 → 297
      5_nucleotid; 5' nucleotidase family

    7. XM_036161724.1 → XP_036017617.1  cytosolic purine 5'-nucleotidase isoform X1

      UniProtKB/Swiss-Prot
      Q3V1L4, Q6P223, Q8BZ43, Q9D8G6
      Conserved Domains (1) summary
      pfam05761
      Location:43 → 488
      5_nucleotid; 5' nucleotidase family

    8. XM_030251131.1 → XP_030106991.1  cytosolic purine 5'-nucleotidase isoform X2

      Conserved Domains (1) summary
      pfam05761
      Location:55 → 357
      5_nucleotid; 5' nucleotidase family

    9. XM_036161728.1 → XP_036017621.1  cytosolic purine 5'-nucleotidase isoform X3

      Conserved Domains (1) summary
      cl17687
      Location:1 → 297
      5_nucleotid; 5' nucleotidase family

    10. XM_036161726.1 → XP_036017619.1  cytosolic purine 5'-nucleotidase isoform X2

      Conserved Domains (1) summary
      pfam05761
      Location:55 → 357
      5_nucleotid; 5' nucleotidase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V1L4.2 GenPept UniProtKB/Swiss-Prot:Q3V1L4

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