Scp2 sterol carrier protein 2, liver [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Scp2provided by MGI
Official Full Name: sterol carrier protein 2, liverprovided by MGI
Primary source: MGI:MGI:98254
See related: Ensembl:ENSMUSG00000028603 AllianceGenome:MGI:98254
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SCPX; SCP-2; SCP-X; NSL-TP; ns-LTP
Summary: Predicted to enable several functions, including C-acyltransferase activity; cholesterol binding activity; and lipid transfer activity. Involved in regulation of phospholipid biosynthetic process. Acts upstream of or within peroxisome organization. Located in endoplasmic reticulum; mitochondrion; and peroxisome. Is expressed in several structures, including central nervous system; hair follicle; intestine; liver; and retina layer. Orthologous to human SCP2 (sterol carrier protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver adult (RPKM 155.8), liver E18 (RPKM 130.2) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C7; 4 50.2 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (107901027..108002168, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (108043830..108144971, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Both FABP1 and SCP-2 participate in regulating the Brain endocannabinoids (EC) system in the brain.
Title: Sterol Carrier Protein-2/Sterol Carrier Protein-x/Fatty Acid Binding Protein-1 Ablation Impacts Response of Brain Endocannabinoid to High-Fat Diet.
These findings suggested that ablation of the Scp-2/Scp-x gene in Fabp1 null mice exacerbated hepatic endocannabinoid (EC) accumulation and antagonized the impact of high fat diet on hepatic EC levels-suggesting both proteins play important roles in regulating the hepatic EC system.
Title: Scp-2/Scp-x ablation in Fabp1 null mice differentially impacts hepatic endocannabinoid level depending on dietary fat.
These results indicate an important regulatory role for SCP2 deficiency in attenuating diet-induced atherosclerosis by limiting intestinal cholesterol absorption and decreasing hepatic triglyceride/VLDL secretion.
Title: Sterol carrier protein-2 deficiency attenuates diet-induced dyslipidemia and atherosclerosis in mice.
Ablating both Fabp1 and Scp2/Scpx (TKO) induces hepatic phospholipid and cholesterol accumulation in high fat-fed mice
Title: Ablating both Fabp1 and Scp2/Scpx (TKO) induces hepatic phospholipid and cholesterol accumulation in high fat-fed mice.
role of Fabp1/Scp-2 in hepatic phytol metabolism
Title: Impact of Fabp1/Scp-2/Scp-x gene ablation (TKO) on hepatic phytol metabolism in mice.
Thus, the loss of Scp-2/Scp-x contributed to a sex-dependent hepatic accumulation of dietary phytol and BCFA.
Title: Sex-dependent impact of Scp-2/Scp-x gene ablation on hepatic phytol metabolism.
Individually ablating SCPx or SCP2/SCPx elicited concomitant upregulation of L-FABP.
Title: Impact of dietary phytol on lipid metabolism in SCP2/SCPX/L-FABP null mice.
Lack of a significant decrease in the flux of HDL-[(3)H]CE to biliary FC or bile acids in FABP1(-/-) mice indicates the likely compensation of its function by an as yet unidentified mechanism. Taken together, these studies demonstrate that FABP1 and SCP2 facilitate the preferential movement of HDL-CEs to bile for final elimination
Title: Intracellular cholesterol transport proteins enhance hydrolysis of HDL-CEs and facilitate elimination of cholesterol into bile.
Sterol Carrier Protein-2, a Nonspecific Lipid-Transfer Protein, in Intracellular Cholesterol Trafficking in Testicular Leydig Cells
Title: Sterol Carrier Protein-2, a Nonspecific Lipid-Transfer Protein, in Intracellular Cholesterol Trafficking in Testicular Leydig Cells.
L-FABP was more important in hepatic retention of bile acids, while SCP-2/SCP-x more broadly affected biliary bile acid and phospholipid levels.
Title: Relative contributions of L-FABP, SCP-2/SCP-x, or both to hepatic biliary phenotype of female mice.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M91458 (e-PCR)
- UniSTS:159265

RH125881 (e-PCR)
- UniSTS:162613

RH126486 (e-PCR)
- UniSTS:163194

RH126008 (e-PCR)
- UniSTS:162720

RH124902 (e-PCR)
- UniSTS:161724

SCP2 (e-PCR)
- UniSTS:105162

RH128646 (e-PCR)
- UniSTS:211954

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetyl-CoA C-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acetyl-CoA C-myristoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables cholesterol binding	ISO Inferred from Sequence Orthology more info
enables cholesterol transfer activity	ISO Inferred from Sequence Orthology more info
enables fatty-acyl-CoA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acyl-CoA binding	ISO Inferred from Sequence Orthology more info
enables oleic acid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine transfer activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylethanolamine transfer activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol transfer activity	ISO Inferred from Sequence Orthology more info
enables propanoyl-CoA C-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables propionyl-CoA C2-trimethyltridecanoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bile acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in inositol trisphosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in intracellular cholesterol transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in lipid hydroperoxide transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in phospholipid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of steroid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in progesterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of phospholipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in steroid biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in peroxisomal matrix	ISO Inferred from Sequence Orthology more info
located_in peroxisomal matrix	TAS Traceable Author Statement more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sterol carrier protein 2

Names: SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; SCP-chi; acetyl-CoA C-myristoyltransferase; non-specific lipid-transfer protein; nonspecific lipid transfer protein; propanoyl-CoA C-acyltransferase; sterol carrier protein X; straight-chain acyl-CoA oxidase

NP_035457.1

EC 2.3.1.155

EC 2.3.1.16

EC 2.3.1.176

XP_011238779.1

EC 2.3.1.155

EC 2.3.1.16

EC 2.3.1.176

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011327.4 → NP_035457.1 sterol carrier protein 2

See identical proteins and their annotated locations for NP_035457.1

Status: VALIDATED

Source sequence(s)

AK004860, BB774576, CJ238474, DN176201, M91458

Consensus CDS

CCDS18446.1

UniProtKB/Swiss-Prot

A2APS2, A2APS3, P32020, Q9DBM7

Related

ENSMUSP00000030340.9, ENSMUST00000030340.15

Conserved Domains (3) summary

PRK08256
Location:12 → 404

PRK08256; lipid-transfer protein; Provisional

cd00826
Location:17 → 403

nondecarbox_cond_enzymes; nondecarboxylating condensing enzymes; In general, thiolases catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. There are 2 ...

pfam02036
Location:452 → 538

SCP2; SCP-2 sterol transfer family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

107901027..108002168 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011240477.2 → XP_011238779.1 sterol carrier protein 2 isoform X1

See identical proteins and their annotated locations for XP_011238779.1

Conserved Domains (2) summary

PRK08256
Location:8 → 388

PRK08256; lipid-transfer protein; Provisional

pfam02036
Location:436 → 522

SCP2; SCP-2 sterol transfer family