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    Gucy1a2 guanylate cyclase 1, soluble, alpha 2 [ Mus musculus (house mouse) ]

    Gene ID: 234889, updated on 12-May-2024

    Summary

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    Official Symbol
    Gucy1a2provided by MGI
    Official Full Name
    guanylate cyclase 1, soluble, alpha 2provided by MGI
    Primary source
    MGI:MGI:2660877
    See related
    Ensembl:ENSMUSG00000041624 AllianceGenome:MGI:2660877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330407I18Rik; A230060L24Rik
    Summary
    Predicted to enable guanylate cyclase activity. Acts upstream of or within positive regulation of nitric oxide mediated signal transduction. Is expressed in several structures, including adrenal gland; nervous system; and urinary system. Orthologous to human GUCY1A2 (guanylate cyclase 1 soluble subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cortex adult (RPKM 2.4), frontal lobe adult (RPKM 2.3) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A1; 9 2.14 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (3532349..3905791)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (3532349..3905791)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr9:3403367-3403668 Neighboring gene STARR-seq mESC enhancer starr_23127 Neighboring gene CWF19 like cell cycle control factor 2 Neighboring gene STARR-seq mESC enhancer starr_23129 Neighboring gene topoisomerase (DNA) II alpha) pseudogene Neighboring gene STARR-seq mESC enhancer starr_23131 Neighboring gene STARR-seq mESC enhancer starr_23133 Neighboring gene STARR-seq mESC enhancer starr_23135 Neighboring gene STARR-seq mESC enhancer starr_23136 Neighboring gene STARR-seq mESC enhancer starr_23138 Neighboring gene STARR-seq mESC enhancer starr_23139 Neighboring gene STARR-seq mESC enhancer starr_23140 Neighboring gene STARR-seq mESC enhancer starr_23142 Neighboring gene STARR-seq mESC enhancer starr_23143 Neighboring gene STARR-seq mESC enhancer starr_23144 Neighboring gene STARR-seq mESC enhancer starr_23145 Neighboring gene STARR-seq mESC enhancer starr_23147 Neighboring gene STARR-seq mESC enhancer starr_23148 Neighboring gene STARR-seq mESC enhancer starr_23152 Neighboring gene predicted gene, 45957 Neighboring gene aldose reductase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. circ-Gucy1a2 Protects Mice from Cerebral Ischemia-Reperfusion Injury by Attenuating Neuronal Apoptosis and Mitochondrial Membrane Potential Loss. Wang F, et al. J Invest Surg, 2023 Dec. PMID 37277119
    2. Postsynaptic NO/cGMP increases NMDA receptor currents via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampus. Neitz A, et al. Cereb Cortex, 2014 Jul. PMID 23448871
    3. Presynaptic nitric oxide/cGMP facilitates glutamate release via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampus. Neitz A, et al. Eur J Neurosci, 2011 May. PMID 21410795
    4. More than a retrograde messenger: nitric oxide needs two cGMP pathways to induce hippocampal long-term potentiation. Taqatqeh F, et al. J Neurosci, 2009 Jul 22. PMID 19625524, Free PMC Article
    5. Gastric motility in soluble guanylate cyclase alpha 1 knock-out mice. Vanneste G, et al. J Physiol, 2007 Nov 1. PMID 17717014, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. circ-Gucy1a2 Protects Mice from Cerebral Ischemia-Reperfusion Injury by Attenuating Neuronal Apoptosis and Mitochondrial Membrane Potential Loss.
      Title: circ-Gucy1a2 Protects Mice from Cerebral Ischemia-Reperfusion Injury by Attenuating Neuronal Apoptosis and Mitochondrial Membrane Potential Loss.
    2. These data suggests a novel physiological role for PDE5 in restricting the effects of NOS3/sGC/PKG signaling pathway to modulating beta-AR stimulated I(Ca), while limiting effects on cardiac contraction.[sGC]
      Title: Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes.
    3. The aim of this study was to investigate the role of Gucy1a2 in nitrergic regulation of gastric motility in male and female Gucy1a2 knock-out mice.
      Title: Gastric motility in soluble guanylate cyclase alpha 1 knock-out mice.
    4. Requirement of both alpha-2 and alpha-1 guanylate cyclases for signaling in long-term potentiation (LTP) indicates the existence of two distinct nitric oxide/cGMP-mediated pathways, which have to work in concert for expression of LTP.
      Title: Long-term potentiation in the visual cortex requires both nitric oxide receptor guanylyl cyclases.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of nitric oxide mediated signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of nitric oxide mediated signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxygen levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of guanylate cyclase complex, soluble IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    guanylate cyclase soluble subunit alpha-2
    NP_001028494.1
    XP_011240663.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033322.3 → NP_001028494.1  guanylate cyclase soluble subunit alpha-2

      See identical proteins and their annotated locations for NP_001028494.1

      Status: VALIDATED

      Source sequence(s)
      AC118473, AC122444, AC156642
      Consensus CDS
      CCDS40526.1
      UniProtKB/TrEMBL
      F8VQK3
      Related
      ENSMUSP00000111398.2, ENSMUST00000115733.3
      Conserved Domains (4) summary
      smart00044
      Location:483 → 672
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:512 → 696
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07700
      Location:157 → 268
      HNOB; Haem-NO-binding
      pfam07701
      Location:314 → 501
      HNOBA; Heme NO binding associated

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      3532349..3905791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242361.2 → XP_011240663.1  guanylate cyclase soluble subunit alpha-2 isoform X1

      Conserved Domains (3) summary
      pfam00211
      Location:428 → 612
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:230 → 417
      HNOBA; Heme NO binding associated
      pfam07700
      Location:68 → 184
      HNOB; Haem-NO-binding
    Nucleotide Protein Strain
    Heading Accession and Version

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