KLC4 kinesin light chain 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KLC4provided by HGNC
Official Full Name: kinesin light chain 4provided by HGNC
Primary source: HGNC:HGNC:21624
See related: Ensembl:ENSG00000137171 AllianceGenome:HGNC:21624
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KNSL8; bA387M24.3
Summary: Predicted to be located in cytoplasm and microtubule. Predicted to be part of kinesin complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in duodenum (RPKM 24.3), small intestine (RPKM 22.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p21.1

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (43059631..43075093)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (42888702..42903839)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (43027369..43042831)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kinesin light chain 4 as a new target for lung cancer chemoresistance via targeted inhibition of checkpoint kinases in the DNA repair network.
Title: Kinesin light chain 4 as a new target for lung cancer chemoresistance via targeted inhibition of checkpoint kinases in the DNA repair network.
Findings indicate that SET domain protein 3 (SETD3) down-regulated the expression of kinesin light chain 4 (KLC4), contributing to the radiosensitivity of cervical cancer cells, suggesting targeting SETD3 might be a potential strategy for the clinical management of cervical cancer.
Title: SETD3 reduces KLC4 expression to improve the sensitization of cervical cancer cell to radiotherapy.
The association of a KLC4 mutation with spastic paraplegia identifies a new locus for the disease.
Title: Hereditary spastic paraplegia with recessive trait caused by mutation in KLC4 gene.
Data reveal aspects of the molecular mechanism of kinesin-8 motors that contribute to their unique dual motile and depolymerising functions, which are adapted to control microtubule length.
Title: Insight into the molecular mechanism of the multitasking kinesin-8 motor.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-R52053 (e-PCR)
- UniSTS:61442

RH103422 (e-PCR)
- UniSTS:97747

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables kinesin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of kinesin complex	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kinesin light chain 4

Names: kinesin-like protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289034.2 → NP_001275963.1 kinesin light chain 4 isoform a

See identical proteins and their annotated locations for NP_001275963.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1, 2 and 5 encode the same isoform (a), which has a shorter N-terminus, compared to isoform b.

Source sequence(s)

AK056393, BC080637, BX640717

Consensus CDS

CCDS4883.1

UniProtKB/Swiss-Prot

B3KNY4, B3KPI3, B3KSQ3, B4DME9, Q66K28, Q96EG6, Q9NSK0

Related

ENSP00000418031.1, ENST00000479388.5

Conserved Domains (3) summary

TIGR02168
Location:33 → 148

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

sd00006
Location:295 → 323

TPR; TPR repeat [structural motif]

pfam13424
Location:294 → 368

TPR_12; Tetratricopeptide repeat
NM_001289035.2 → NP_001275964.1 kinesin light chain 4 isoform d

See identical proteins and their annotated locations for NP_001275964.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) contains an alternate 5' terminal exon, initiates translation at a downstream start codon and lacks an alternate in-frame exon in the 5' coding region, compared to variant 3. It encodes isoform d, which is shorter than isoform b.

Source sequence(s)

AK297433, BC080637

Consensus CDS

CCDS75459.1

UniProtKB/Swiss-Prot

Q9NSK0

Related

ENSP00000395806.2, ENST00000453940.6

Conserved Domains (2) summary

sd00006
Location:218 → 246

TPR; TPR repeat [structural motif]

pfam13424
Location:217 → 291

TPR_12; Tetratricopeptide repeat
NM_138343.4 → NP_612352.1 kinesin light chain 4 isoform c

See identical proteins and their annotated locations for NP_612352.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and the 5' coding region and contains a 3' terminal exon that extends past a splice site, compared to variant 3. It encodes isoform c, which is shorter and has a distinct C-terminus, compared to isoform b.

Source sequence(s)

BC012357, DA782235

Consensus CDS

CCDS47429.1

UniProtKB/Swiss-Prot

Q9NSK0

Related

ENSP00000410358.2, ENST00000458460.6

Conserved Domains (3) summary

TIGR02168
Location:33 → 148

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

sd00006
Location:212 → 239

TPR; TPR repeat [structural motif]

pfam13424
Location:210 → 285

TPR_12; Tetratricopeptide repeat
NM_201521.3 → NP_958929.1 kinesin light chain 4 isoform a

See identical proteins and their annotated locations for NP_958929.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1, 2 and 5 encode the same isoform (a), which has a shorter N-terminus, compared to isoform b.

Source sequence(s)

BC080637, DA782235

Consensus CDS

CCDS4883.1

UniProtKB/Swiss-Prot

B3KNY4, B3KPI3, B3KSQ3, B4DME9, Q66K28, Q96EG6, Q9NSK0

Related

ENSP00000340221.5, ENST00000347162.10

Conserved Domains (3) summary

TIGR02168
Location:33 → 148

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

sd00006
Location:295 → 323

TPR; TPR repeat [structural motif]

pfam13424
Location:294 → 368

TPR_12; Tetratricopeptide repeat
NM_201522.3 → NP_958930.1 kinesin light chain 4 isoform a

See identical proteins and their annotated locations for NP_958930.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1, 2 and 5 encode the same isoform (a), which has a shorter N-terminus, compared to isoform b.

Source sequence(s)

AK055293, AK056393, BC080637, DA835055

Consensus CDS

CCDS4883.1

UniProtKB/Swiss-Prot

B3KNY4, B3KPI3, B3KSQ3, B4DME9, Q66K28, Q96EG6, Q9NSK0

Related

ENSP00000377620.2, ENST00000394056.6

Conserved Domains (3) summary

TIGR02168
Location:33 → 148

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

sd00006
Location:295 → 323

TPR; TPR repeat [structural motif]

pfam13424
Location:294 → 368

TPR_12; Tetratricopeptide repeat
NM_201523.3 → NP_958931.1 kinesin light chain 4 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3) encodes the longest isoform (b).

Source sequence(s)

AK094102, BC080637

Consensus CDS

CCDS4882.1

UniProtKB/Swiss-Prot

Q9NSK0

Related

ENSP00000259708.3, ENST00000259708.7

Conserved Domains (3) summary

sd00006
Location:313 → 341

TPR; TPR repeat [structural motif]

pfam13424
Location:312 → 386

TPR_12; Tetratricopeptide repeat

cl25732
Location:51 → 166

SMC_N; RecF/RecN/SMC N terminal domain