Ngb neuroglobin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ngbprovided by RGD
Official Full Name: neuroglobinprovided by RGD
Primary source: RGD:621461
See related: Ensembl:ENSRNOG00000011719 AllianceGenome:RGD:621461
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Glnh
Summary: Predicted to enable oxygen carrier activity. Involved in several processes, including negative regulation of hydrogen peroxide-induced cell death; response to iron ion; and visual perception. Located in mitochondrion; neuron projection; and perikaryon. Used to study transient cerebral ischemia. Biomarker of Alzheimer's disease; encephalitis; retinal ischemia; and transient cerebral ischemia. Orthologous to human NGB (neuroglobin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 17.7), Adrenal (RPKM 10.8) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q31

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (112475332..112480786, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (106744378..106749830, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (111126259..111131699, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuroglobin Facilitates Neuronal Oxygenation through Tropic Migration under Hypoxia or Anemia in Rat: How Does the Brain Breathe?
Title: Neuroglobin Facilitates Neuronal Oxygenation through Tropic Migration under Hypoxia or Anemia in Rat: How Does the Brain Breathe?
Expression Pattern of Ngb in Astrocytes after Spinal Cord Injury and the Clinical Significance.
Title: Expression Pattern of Ngb in Astrocytes after Spinal Cord Injury and the Clinical Significance.
A neuroglobin-based high-affinity ligand trap reverses carbon monoxide-induced mitochondrial poisoning.
Title: A neuroglobin-based high-affinity ligand trap reverses carbon monoxide-induced mitochondrial poisoning.
Ngb upregulation in CA1 after hypoxic postconditioning maintained the membranous level of Atp1b1 through Ngb-Atp1b1 interaction.
Title: Neuroglobin mediates neuroprotection of hypoxic postconditioning against transient global cerebral ischemia in rats through preserving the activity of Na(+)/K(+) ATPases.
Cerebral hemorrhage significantly inhibited the spatial learning and memory ability of rats; the mechanism may be related to decreased cerebral expression of BDNF and NGB
Title: The expression and mechanism of BDNF and NGB in perihematomal tissue in rats with intracerebral hemorrhage.
In conclusion, this study shows that EPOR and Ngb were upregulated, and both of them act as important coordinated neuroprotectors in rh-EPO treatment of PWMD. However, the two proteins exhibit different expression patterns.
Title: Recombinant human erythropoietin offers neuroprotection through inducing endogenous erythropoietin receptor and neuroglobin in a neonatal rat model of periventricular white matter damage.
Ngb expression is limited to the subpopulation of type I spiral ganglion cells, those which innervate inner hair cells, while the subpopulation of type II spiral ganglion cells which innervate the outer hair cells do not express Ngb. The cochlear nuclei and superior olivary complex (SOC) also express considerable amounts of Ngb.
Title: Neuroglobin Expression in the Mammalian Auditory System.
The present study first reported the yeast expressed production of Tat-NGB-His and His-NGB-His, and then elucidated the transduction and neuroprotection of Tat-NGB-His on PC12 cell
Title: Pichia pastoris Production of Tat-NGB and Its Neuroprotection on Rat Pheochromocytoma Cells.
Intermittent hypobaric hypoxia preconditioning activated the expression of neuroglobin and Bcl-2 in the rat hippocampal CA1 area following ischemia-reperfusion, and prevented hippocampal neuronal apoptosis.
Title: Effects of intermittent hypobaric hypoxia preconditioning on the expression of neuroglobin and Bcl-2 in the rat hippocampal CA1 area following ischemia-reperfusion.
NEUROGLOBIN DISTRIBUTION IN THE RAT CEREBELLAR PURKINJE CELLS
Title: [NEUROGLOBIN DISTRIBUTION IN THE RAT CEREBELLAR PURKINJE CELLS].

Submit: New GeneRIF Correction See all GeneRIFs (43)

General gene information

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Markers

RH143985 (e-PCR)
- UniSTS:233231

NGB (e-PCR)
- UniSTS:511983

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GDP-dissociation inhibitor activity	IEA Inferred from Electronic Annotation more info
enables GDP-dissociation inhibitor activity	ISO Inferred from Sequence Orthology more info
enables GDP-dissociation inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nitrite reductase activity	IEA Inferred from Electronic Annotation more info
enables nitrite reductase activity	ISO Inferred from Sequence Orthology more info
enables nitrite reductase activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxygen binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen binding	IEA Inferred from Electronic Annotation more info
enables oxygen binding	ISO Inferred from Sequence Orthology more info
enables oxygen binding	ISS Inferred from Sequence or Structural Similarity more info
enables oxygen carrier activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen carrier activity	IEA Inferred from Electronic Annotation more info
enables oxygen carrier activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oxygen transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in oxygen transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oxygen transport	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to iron ion	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neuroglobin

Names: globin h; nitrite reductase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.