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    Ttll5 tubulin tyrosine ligase like 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299208, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Ttll5provided by RGD
    Official Full Name
    tubulin tyrosine ligase like 5provided by RGD
    Primary source
    RGD:1563583
    See related
    Ensembl:ENSRNOG00000009318 AllianceGenome:RGD:1563583
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563583
    Summary
    Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization and protein polyglutamylation. Predicted to act upstream of or within fertilization; retina development in camera-type eye; and sperm axoneme assembly. Predicted to be located in several cellular components, including 9+0 non-motile cilium; cytosol; and microtubule organizing center. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in cone-rod dystrophy 19. Orthologous to human TTLL5 (tubulin tyrosine ligase like 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 128.7), Brain (RPKM 115.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    6q31
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (111214048..111431892)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (105483091..105700920)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (109693915..109910479)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351275 Neighboring gene basic leucine zipper ATF-like transcription factor Neighboring gene uncharacterized LOC120103579 Neighboring gene FLVCR choline and putative heme transporter 2 Neighboring gene ergosterol biosynthesis 28 homolog Neighboring gene uncharacterized LOC134479235 Neighboring gene transforming growth factor, beta 3 Neighboring gene intraflagellar transport 43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Disruption of Ttll5/stamp gene (tubulin tyrosine ligase-like protein 5/SRC-1 and TIF2-associated modulatory protein gene) in male mice causes sperm malformation and infertility. Lee GS, et al. J Biol Chem, 2013 May 24. PMID 23558686, Free PMC Article
    2. Mutations in the polyglutamylase gene TTLL5, expressed in photoreceptor cells and spermatozoa, are associated with cone-rod degeneration and reduced male fertility. Bedoni N, et al. Hum Mol Genet, 2016 Oct 15. PMID 28173158
    3. Biallelic variants in TTLL5, encoding a tubulin glutamylase, cause retinal dystrophy. Sergouniotis PI, et al. Am J Hum Genet, 2014 May 1. PMID 24791901, Free PMC Article
    4. A targeted multienzyme mechanism for selective microtubule polyglutamylation. van Dijk J, et al. Mol Cell, 2007 May 11. PMID 17499049
    5. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TTLL5 was found in the basal body of photoreceptor cells in rat
      Title: Mutations in the polyglutamylase gene TTLL5, expressed in photoreceptor cells and spermatozoa, are associated with cone-rod degeneration and reduced male fertility.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyglutamylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within retina development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sperm axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in 9+0 non-motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tubulin polyglutamylase TTLL5
    Names
    tubulin tyrosine ligase-like family, member 5
    NP_001414219.1
    XP_038969238.1
    XP_038969239.1
    XP_038969240.1
    XP_038969241.1
    XP_038969242.1
    XP_038969243.1
    XP_038969244.1
    XP_038969245.1
    XP_038969246.1
    XP_038969247.1
    XP_038969248.1
    XP_038969250.1
    XP_038969251.1
    XP_038969252.1
    XP_038969253.1
    XP_038969254.1
    XP_063117825.1
    XP_063117826.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427290.1 → NP_001414219.1  tubulin polyglutamylase TTLL5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      D3ZAA1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      111214048..111431892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039113313.2 → XP_038969241.1  tubulin polyglutamylase TTLL5 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ACV1, A0A8I6GJ32
      Related
      ENSRNOP00000092001.1
      Conserved Domains (1) summary
      pfam03133
      Location:117 → 395
      TTL; Tubulin-tyrosine ligase family

    2. XM_039113315.2 → XP_038969243.1  tubulin polyglutamylase TTLL5 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GJ32
      Conserved Domains (1) summary
      pfam03133
      Location:117 → 395
      TTL; Tubulin-tyrosine ligase family

    3. XM_063261755.1 → XP_063117825.1  tubulin polyglutamylase TTLL5 isoform X10

    4. XM_039113312.2 → XP_038969240.1  tubulin polyglutamylase TTLL5 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GJ32
      Conserved Domains (1) summary
      pfam03133
      Location:117 → 395
      TTL; Tubulin-tyrosine ligase family

    5. XM_039113317.2 → XP_038969245.1  tubulin polyglutamylase TTLL5 isoform X7

      UniProtKB/TrEMBL
      A0A8I6AL69, A0A8I6GJ32
      Related
      ENSRNOP00000094535.1
      Conserved Domains (1) summary
      pfam03133
      Location:117 → 395
      TTL; Tubulin-tyrosine ligase family

    6. XM_039113318.2 → XP_038969246.1  tubulin polyglutamylase TTLL5 isoform X8

      UniProtKB/TrEMBL
      A0A8I6GJ32
      Conserved Domains (1) summary
      pfam03133
      Location:117 → 395
      TTL; Tubulin-tyrosine ligase family

    7. XM_039113314.2 → XP_038969242.1  tubulin polyglutamylase TTLL5 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZKQ8, A0A8I6GJ32
      Related
      ENSRNOP00000078338.1
      Conserved Domains (1) summary
      pfam03133
      Location:117 → 395
      TTL; Tubulin-tyrosine ligase family

    8. XM_039113326.2 → XP_038969254.1  tubulin polyglutamylase TTLL5 isoform X15

      Conserved Domains (1) summary
      pfam03133
      Location:117 → 395
      TTL; Tubulin-tyrosine ligase family

    9. XM_039113311.2 → XP_038969239.1  tubulin polyglutamylase TTLL5 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GJ32, D3ZAA1
      Related
      ENSRNOP00000012895.8
      Conserved Domains (1) summary
      pfam03133
      Location:117 → 395
      TTL; Tubulin-tyrosine ligase family

    10. XM_063261756.1 → XP_063117826.1  tubulin polyglutamylase TTLL5 isoform X10

    11. XM_039113310.2 → XP_038969238.1  tubulin polyglutamylase TTLL5 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GJ32, D3ZAA1
      Conserved Domains (1) summary
      pfam03133
      Location:117 → 395
      TTL; Tubulin-tyrosine ligase family

    12. XM_039113316.2 → XP_038969244.1  tubulin polyglutamylase TTLL5 isoform X6

      UniProtKB/TrEMBL
      A0A8I6GJ32
      Conserved Domains (1) summary
      pfam03133
      Location:19 → 297
      TTL; Tubulin-tyrosine ligase family

    13. XM_039113319.2 → XP_038969247.1  tubulin polyglutamylase TTLL5 isoform X9

      UniProtKB/TrEMBL
      A0A8I6GJ32
      Conserved Domains (1) summary
      pfam03133
      Location:1 → 255
      TTL; Tubulin-tyrosine ligase family

    14. XM_039113320.2 → XP_038969248.1  tubulin polyglutamylase TTLL5 isoform X11

      UniProtKB/TrEMBL
      A6JE47
      Conserved Domains (1) summary
      cl17255
      Location:2 → 149
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    15. XM_039113324.2 → XP_038969252.1  tubulin polyglutamylase TTLL5 isoform X13

      UniProtKB/TrEMBL
      A6JE47

    16. XM_039113322.2 → XP_038969250.1  tubulin polyglutamylase TTLL5 isoform X12

      UniProtKB/TrEMBL
      A6JE47

    17. XM_039113323.2 → XP_038969251.1  tubulin polyglutamylase TTLL5 isoform X13

      UniProtKB/TrEMBL
      A6JE47

    18. XM_039113325.2 → XP_038969253.1  tubulin polyglutamylase TTLL5 isoform X14

      UniProtKB/TrEMBL
      A6JE50
    Nucleotide Protein Strain
    Heading Accession and Version

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