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    Abi3bp ABI family member 3 binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363767, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Abi3bpprovided by RGD
    Official Full Name
    ABI family member 3 binding proteinprovided by RGD
    Primary source
    RGD:1562717
    See related
    Ensembl:ENSRNOG00000001627 AllianceGenome:RGD:1562717
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562717
    Summary
    Enables actin filament binding activity. Involved in regulation of actin cytoskeleton reorganization; regulation of dendritic spine morphogenesis; and regulation of postsynaptic density assembly. Located in dendrite; lamellipodium; and postsynaptic density. Orthologous to human ABI3BP (ABI family member 3 binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 260.0), Lung (RPKM 129.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    11q12
    Exon count:
    60
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (57381282..57597989, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (43912187..44128888, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (46206932..46422791, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor G7 Neighboring gene uncharacterized LOC134481066 Neighboring gene trafficking from ER to golgi regulator Neighboring gene uncharacterized LOC134481065 Neighboring gene cell cycle associated protein 1, pseudogene 1 Neighboring gene interphotoreceptor matrix proteoglycan 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. F-actin-dependent regulation of NESH dynamics in rat hippocampal neurons. Bae J, et al. PLoS One, 2012. PMID 22496823, Free PMC Article
    2. NESH regulates dendritic spine morphology and synapse formation. Bae J, et al. PLoS One, 2012. PMID 22485184, Free PMC Article
    3. Insulin receptor substrate protein 53 (IRSp53) as a binding partner of antimetastasis molecule NESH, a member of Abelson interactor protein family. Matsuda S, et al. Ann Oncol, 2008 Jul. PMID 18480067
    4. Transcriptome-based systematic identification of extracellular matrix proteins. Manabe R, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18757743, Free PMC Article
    5. Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Barallobre-Barreiro J, et al. Circulation, 2016 Sep 13. PMID 27559042, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycosaminoglycan binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to tumor cell ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of connective tissue replacement involved in inflammatory response wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cardiocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell-substrate adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cellular senescence ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynaptic density assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendritic shaft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in interstitial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    target of Nesh-SH3
    Names
    ABI family, member 3 (NESH) binding protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      57381282..57597989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598136.3 → XP_017453625.1  target of Nesh-SH3 isoform X28

      UniProtKB/TrEMBL
      A0A8I6AGS4

    2. XM_017598128.3 → XP_017453617.1  target of Nesh-SH3 isoform X14

      UniProtKB/TrEMBL
      A0A8I6AGS4

    3. XM_063270909.1 → XP_063126979.1  target of Nesh-SH3 isoform X23

    4. XM_017598132.3 → XP_017453621.1  target of Nesh-SH3 isoform X22

      UniProtKB/TrEMBL
      A0A8I6AGS4

    5. XM_063270929.1 → XP_063126999.1  target of Nesh-SH3 isoform X48

    6. XM_063270907.1 → XP_063126977.1  target of Nesh-SH3 isoform X19

    7. XM_017598129.3 → XP_017453618.1  target of Nesh-SH3 isoform X17

      UniProtKB/TrEMBL
      A0A8I6AGS4

    8. XM_017598127.3 → XP_017453616.1  target of Nesh-SH3 isoform X13

      UniProtKB/TrEMBL
      A0A8I6AGS4

    9. XM_039088841.2 → XP_038944769.1  target of Nesh-SH3 isoform X47

      UniProtKB/TrEMBL
      F1M1N9
      Conserved Domains (3) summary
      PHA03247
      Location:358 → 887
      PHA03247; large tegument protein UL36; Provisional
      cd00063
      Location:865 → 956
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:116 → 195
      fn3; Fibronectin type III domain

    10. XM_008768669.4 → XP_008766891.1  target of Nesh-SH3 isoform X46

      See identical proteins and their annotated locations for XP_008766891.1

      UniProtKB/TrEMBL
      F1M1N9, M0R8H8
      Related
      ENSRNOP00000065774.3
      Conserved Domains (3) summary
      cd00063
      Location:890 → 981
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:116 → 204
      fn3; Fibronectin type III domain
      pfam06217
      Location:473 → 572
      GAGA_bind; GAGA binding protein-like family

    11. XM_063270910.1 → XP_063126980.1  target of Nesh-SH3 isoform X24

    12. XM_063270904.1 → XP_063126974.1  target of Nesh-SH3 isoform X15

    13. XM_017598123.3 → XP_017453612.1  target of Nesh-SH3 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AGS4

    14. XM_063270928.1 → XP_063126998.1  target of Nesh-SH3 isoform X45

    15. XM_063270900.1 → XP_063126970.1  target of Nesh-SH3 isoform X4

    16. XM_039088839.2 → XP_038944767.1  target of Nesh-SH3 isoform X44

      UniProtKB/TrEMBL
      A0A8I6ATG1, M0R4H0
      Related
      ENSRNOP00000096503.1
      Conserved Domains (3) summary
      PHA03247
      Location:328 → 748
      PHA03247; large tegument protein UL36; Provisional
      cd00063
      Location:993 → 1084
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:116 → 195
      fn3; Fibronectin type III domain

    17. XM_006248232.5 → XP_006248294.1  target of Nesh-SH3 isoform X41

      See identical proteins and their annotated locations for XP_006248294.1

      UniProtKB/TrEMBL
      M0R4H0
      Related
      ENSRNOP00000049004.6
      Conserved Domains (2) summary
      cd00063
      Location:1018 → 1109
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:116 → 204
      fn3; Fibronectin type III domain

    18. XM_063270919.1 → XP_063126989.1  target of Nesh-SH3 isoform X34

    19. XM_063270927.1 → XP_063126997.1  target of Nesh-SH3 isoform X43

    20. XM_063270925.1 → XP_063126995.1  target of Nesh-SH3 isoform X40

    21. XM_039088834.2 → XP_038944762.1  target of Nesh-SH3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AGS4
      Related
      ENSRNOP00000092554.1
      Conserved Domains (3) summary
      PHA03247
      Location:358 → 897
      PHA03247; large tegument protein UL36; Provisional
      cd00063
      Location:1359 → 1450
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:116 → 195
      fn3; Fibronectin type III domain

    22. XM_063270926.1 → XP_063126996.1  target of Nesh-SH3 isoform X42

    23. XM_063270924.1 → XP_063126994.1  target of Nesh-SH3 isoform X39

    24. XM_063270923.1 → XP_063126993.1  target of Nesh-SH3 isoform X38

    25. XM_063270921.1 → XP_063126991.1  target of Nesh-SH3 isoform X36

    26. XM_063270908.1 → XP_063126978.1  target of Nesh-SH3 isoform X21

    27. XM_063270922.1 → XP_063126992.1  target of Nesh-SH3 isoform X37

      UniProtKB/TrEMBL
      A0A8I6A422

    28. XM_063270920.1 → XP_063126990.1  target of Nesh-SH3 isoform X35

    29. XM_063270918.1 → XP_063126988.1  target of Nesh-SH3 isoform X33

    30. XM_063270906.1 → XP_063126976.1  target of Nesh-SH3 isoform X18

    31. XM_063270902.1 → XP_063126972.1  target of Nesh-SH3 isoform X10

    32. XM_063270916.1 → XP_063126986.1  target of Nesh-SH3 isoform X31

    33. XM_017598124.3 → XP_017453613.1  target of Nesh-SH3 isoform X9

      UniProtKB/TrEMBL
      A0A8I6AGS4

    34. XM_017598120.3 → XP_017453609.1  target of Nesh-SH3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AGS4

    35. XM_063270917.1 → XP_063126987.1  target of Nesh-SH3 isoform X32

    36. XM_063270915.1 → XP_063126985.1  target of Nesh-SH3 isoform X30

    37. XM_063270914.1 → XP_063126984.1  target of Nesh-SH3 isoform X29

    38. XM_063270913.1 → XP_063126983.1  target of Nesh-SH3 isoform X27

    39. XM_063270912.1 → XP_063126982.1  target of Nesh-SH3 isoform X26

    40. XM_063270911.1 → XP_063126981.1  target of Nesh-SH3 isoform X25

    41. XM_063270905.1 → XP_063126975.1  target of Nesh-SH3 isoform X16

    42. XM_017598121.3 → XP_017453610.1  target of Nesh-SH3 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AGS4

    43. XM_063270901.1 → XP_063126971.1  target of Nesh-SH3 isoform X5

    44. XM_017598122.3 → XP_017453611.1  target of Nesh-SH3 isoform X7

      UniProtKB/TrEMBL
      A0A8I6AGS4

    45. XM_017598125.3 → XP_017453614.1  target of Nesh-SH3 isoform X11

      UniProtKB/TrEMBL
      A0A8I6AGS4

    46. XM_017598131.3 → XP_017453620.1  target of Nesh-SH3 isoform X20

      UniProtKB/TrEMBL
      A0A8I6AGS4

    47. XM_017598126.3 → XP_017453615.1  target of Nesh-SH3 isoform X12

      UniProtKB/TrEMBL
      A0A8I6AGS4

    48. XM_017598119.3 → XP_017453608.1  target of Nesh-SH3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AGS4

    RNA

    1. XR_010056273.1 RNA Sequence

    2. XR_010056272.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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