Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Uba52provided by RGD
Official Full Name: ubiquitin A-52 residue ribosomal protein fusion product 1provided by RGD
Primary source: RGD:68344
See related: Ensembl:ENSRNOG00000019971 AllianceGenome:RGD:68344
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ubb; Rps27a
Summary: Predicted to enable protein tag and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of ribosome. Involved in response to insecticide. Located in cytoplasm and nucleus. Part of cytosolic large ribosomal subunit. Orthologous to human UBA52 (ubiquitin A-52 residue ribosomal protein fusion product 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 2356.7), Heart (RPKM 2317.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (18952583..18954780)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (18918614..18920807)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (20668925..20671127)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UBA52 Attunes VDAC1-Mediated Mitochondrial Dysfunction and Dopaminergic Neuronal Death.
Title: UBA52 Attunes VDAC1-Mediated Mitochondrial Dysfunction and Dopaminergic Neuronal Death.
Males and females differ in the regulation and engagement of, but not requirement for, protein degradation in the amygdala during fear memory formation.
Title: Males and females differ in the regulation and engagement of, but not requirement for, protein degradation in the amygdala during fear memory formation.
Uba52 protein was restrictedly localized within the surface of the marginal cells of the stria vascularis of cochlea.
Title: The localization of proteins encoded by CRYM, KIAA1199, UBA52, COL9A3, and COL9A1, genes highly expressed in the cochlea.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH131774 (e-PCR)
- UniSTS:215057

AA555564 (e-PCR)
- UniSTS:206909

RH128982 (e-PCR)
- UniSTS:212290

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein tag activity	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info
enables structural constituent of ribosome	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in modification-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to insecticide	IEP Inferred from Expression Pattern more info	PubMed
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of rough endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of cytosolic large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic large ribosomal subunit	ISO Inferred from Sequence Orthology more info
located_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
part_of cytosolic small ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
part_of large ribosomal subunit	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin-ribosomal protein eL40 fusion protein

Names: 60S ribosomal protein L40; CEP52; ubiquitin-60S ribosomal protein L40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031687.3 → NP_113875.1 ubiquitin-ribosomal protein eL40 fusion protein

See identical proteins and their annotated locations for NP_113875.1

Status: VALIDATED

Source sequence(s)

BC061544, BP480615, BP492585

UniProtKB/Swiss-Prot

P62986, P62989, Q63446

UniProtKB/TrEMBL

Q6P7R7

Conserved Domains (2) summary

cd01803
Location:1 → 76

Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin

pfam01020
Location:79 → 126

Ribosomal_L40e; Ribosomal L40e family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

18952583..18954780

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275684.1 → XP_063131754.1 ubiquitin-ribosomal protein eL40 fusion protein isoform X2
XM_008771146.4 → XP_008769368.1 ubiquitin-ribosomal protein eL40 fusion protein isoform X3

See identical proteins and their annotated locations for XP_008769368.1

UniProtKB/Swiss-Prot

P62986, P62989, Q63446

UniProtKB/TrEMBL

Q6P7R7

Conserved Domains (2) summary

cd01803
Location:1 → 76

Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin

pfam01020
Location:79 → 126

Ribosomal_L40e; Ribosomal L40e family
XM_039094805.2 → XP_038950733.1 ubiquitin-ribosomal protein eL40 fusion protein isoform X1

Conserved Domains (2) summary

cd01803
Location:42 → 117

Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin

pfam01020
Location:120 → 167

Ribosomal_L40e; Ribosomal L40e family
XM_006252935.2 → XP_006252997.1 ubiquitin-ribosomal protein eL40 fusion protein isoform X3

See identical proteins and their annotated locations for XP_006252997.1

UniProtKB/Swiss-Prot

P62986, P62989, Q63446

UniProtKB/TrEMBL

Q6P7R7

Related

ENSRNOP00000027073.3

Conserved Domains (2) summary

cd01803
Location:1 → 76

Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin

pfam01020
Location:79 → 126

Ribosomal_L40e; Ribosomal L40e family
XM_063275685.1 → XP_063131755.1 ubiquitin-ribosomal protein eL40 fusion protein isoform X3

UniProtKB/Swiss-Prot

P62986, P62989, Q63446

UniProtKB/TrEMBL

Q6P7R7