Glo1 glyoxalase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Glo1provided by RGD
Official Full Name: glyoxalase 1provided by RGD
Primary source: RGD:2702
See related: Ensembl:ENSRNOG00000000541 AllianceGenome:RGD:2702
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables lactoylglutathione lyase activity. Involved in carbohydrate metabolic process; glutathione metabolic process; and methylglyoxal metabolic process. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 1139.0), Heart (RPKM 642.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (8665061..8683095, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (8663617..8681661, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (9273589..9291608, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of GLO1 promoted while overexpression of GLO1 prevented angiotensin II -induced cell proliferation and cell cycle transition in rat basilar smooth muscle cells.
Title: Reduction of glyoxalase 1 (GLO1) aggravates cerebrovascular remodeling via promoting the proliferation of basilar smooth muscle cells in hypertension.
Diabetes-induced impairment of arteriogenic adaptation can be partially rescued by overexpressing of GLO-I, indicating a role of AGEs in diabetes-induced impaired collateral formation
Title: Glyoxalase-1 overexpression partially prevents diabetes-induced impaired arteriogenesis in a rat hindlimb ligation model.
These results show the importance of Glo-I as major detoxifying enzyme for methylglyoxal in cirrhosis. The reduced expression of Glo-I in cirrhosis demonstrates a possible explanation for increased inflammatory injury and suggests a "vicious circle" in liver disease.
Title: Expression of glyoxalase-I is reduced in cirrhotic livers: A possible mechanism in the development of cirrhosis.
Increased biosynthesis of collagens 1 and 4 was detected at mRNA and protein level following knockdown of glyoxalase 1 in L6 myoblasts.
Title: Intracellular Accumulation of Methylglyoxal by Glyoxalase 1 Knock Down Alters Collagen Homoeostasis in L6 Myoblasts.
Data suggest that the high dynamics of glyoxalase 1 expression and distribution following neuronal injury may indicate a role of Glyoxalase 1.
Title: Temporal dynamics of glyoxalase 1 in secondary neuronal injury.
GLO1 knock down augmented GLUT4 level on the cell surface of L6 myoblasts at least in part through reduction of GLUT4 internalization.
Title: Impact of GLO1 knock down on GLUT4 trafficking and glucose uptake in L6 myoblasts.
ovarian GLO-I activity may be regulated by dietary composition and androgen levels.
Title: Reduced ovarian glyoxalase-I activity by dietary glycotoxins and androgen excess: a causative link to polycystic ovarian syndrome.
Lower glyoxalase 1 activity in the neuronal tissues was associated with a higher blood glucose concentration.
Title: Glyoxalase 1 and glyoxalase 2 activities in blood and neuronal tissue samples from experimental animal models of obesity and type 2 diabetes mellitus.
Renal ischemia reperfusion-induced tubulointerstitial injury was associated with a deterioration in renal glyoxalase I activity.
Title: Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH133855 (e-PCR)
- UniSTS:217138

RH138820 (e-PCR)
- UniSTS:220907

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lactoylglutathione lyase activity	IDA Inferred from Direct Assay more info	PubMed
enables lactoylglutathione lyase activity	ISO Inferred from Sequence Orthology more info
enables lactoylglutathione lyase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in glutathione metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in methylglyoxal metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in osteoclast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lactoylglutathione lyase

Names: S-D-lactoylglutathione methylglyoxal lyase; aldoketomutase; glx I; glyoxalase I; glyoxylase 1; ketone-aldehyde mutase; methylglyoxalase

NP_997477.1

EC 4.4.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.