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    Cpd carboxypeptidase D [ Mus musculus (house mouse) ]

    Gene ID: 12874, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cpdprovided by MGI
    Official Full Name
    carboxypeptidase Dprovided by MGI
    Primary source
    MGI:MGI:107265
    See related
    Ensembl:ENSMUSG00000020841 AllianceGenome:MGI:107265
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D830034L15Rik
    Summary
    Predicted to enable metallocarboxypeptidase activity and protein phosphatase 2A binding activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to be located in nucleus; perinuclear region of cytoplasm; and trans-Golgi network. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human CPD (carboxypeptidase D). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 23.5), ovary adult (RPKM 18.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B5; 11 46.05 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (76668034..76737834, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (76777208..76847008, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene trafficking regulator of GLUT4 (SLC2A4) 1 Neighboring gene STARR-positive B cell enhancer ABC_E9829 Neighboring gene golgi SNAP receptor complex member 1 Neighboring gene STARR-positive B cell enhancer ABC_E3977 Neighboring gene STARR-seq mESC enhancer starr_30045 Neighboring gene predicted gene, 53688 Neighboring gene predicted gene, 40200 Neighboring gene transmembrane and immunoglobulin domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Analysis of the carboxypeptidase D cytoplasmic domain: Implications in intracellular trafficking. Kalinina E, et al. J Cell Biochem, 2002. PMID 11891854
    2. Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: role of cytochrome P450 2E1 and 2A5. Lu Y, et al. Hepatology, 2006 Jul. PMID 16799984
    3. Palmitoylation of carboxypeptidase D. Implications for intracellular trafficking. Kalinina EV, et al. J Biol Chem, 2003 Mar 14. PMID 12643288
    4. Cloning, functional expression, and chromosomal localization of the human and mouse gp180-carboxypeptidase D-like enzyme. Ishikawa T, et al. Gene, 1998 Jul 30. PMID 9714835
    5. Cloning and sequence analysis of cDNA encoding rat carboxypeptidase D. Xin X, et al. DNA Cell Biol, 1997 Jul. PMID 9260933

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Palmitoylation of carboxypeptidase D has a role in intracellular trafficking
      Title: Palmitoylation of carboxypeptidase D. Implications for intracellular trafficking.
    2. CPD localization to the TGN requires both static retention involving the C-terminal domain and phosphorylation at a CK2 site, which regulates the binding of adaptor proteins.
      Title: Analysis of the carboxypeptidase D cytoplasmic domain: Implications in intracellular trafficking.
    3. The isolation and characterization of CPD from several haematopoietic tumour cells are reported.
      Title: Characterization of a novel, cytokine-inducible carboxypeptidase D isoform in haematopoietic tumour cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    carboxypeptidase D
    Names
    gp180
    metallocarboxypeptidase D
    NP_031780.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007754.2 → NP_031780.2  carboxypeptidase D precursor

      See identical proteins and their annotated locations for NP_031780.2

      Status: VALIDATED

      Source sequence(s)
      AK137737, AL645479, CJ130378
      Consensus CDS
      CCDS25071.1
      UniProtKB/Swiss-Prot
      O89001, Q5SVH8
      Related
      ENSMUSP00000021201.6, ENSMUST00000021201.6
      Conserved Domains (4) summary
      cd03863
      Location:495 → 790
      M14_CPD_II; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain II subgroup
      cd03868
      Location:86 → 378
      M14_CPD_I; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain I subgroup
      cd11308
      Location:794 → 869
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      cl11393
      Location:929 → 1207
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      76668034..76737834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O89001.2 GenPept UniProtKB/Swiss-Prot:O89001

    Gene LinkOut

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