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    Wdr41 WD repeat domain 41 [ Mus musculus (house mouse) ]

    Gene ID: 218460, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Wdr41provided by MGI
    Official Full Name
    WD repeat domain 41provided by MGI
    Primary source
    MGI:MGI:2445123
    See related
    Ensembl:ENSMUSG00000042015 AllianceGenome:MGI:2445123
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MSTP048; B830029I03Rik
    Summary
    This gene encodes a protein of unknown function, but which contains a WD40 domain consisting of six WD40 repeats. The WD40 domain is one of the most abundant protein domains in eukaryotes, and is found in proteins with widely varying cellular functions. However, proteins with this domain often provide a rigid scaffold for protein-protein interactions. [provided by RefSeq, Aug 2012]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 6.7), cerebellum adult (RPKM 6.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wdr41 in Genome Data Viewer
    Location:
    13 C3- D1; 13 49.22 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (95112226..95161800)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (94976329..95023316)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35313 Neighboring gene STARR-seq mESC enhancer starr_35314 Neighboring gene tubulin cofactor A Neighboring gene STARR-seq mESC enhancer starr_35315 Neighboring gene STARR-seq mESC enhancer starr_35319 Neighboring gene orthopedia homeobox Neighboring gene STARR-seq mESC enhancer starr_35320 Neighboring gene predicted gene, 41024 Neighboring gene predicted gene, 48350 Neighboring gene phosphodiesterase 8B Neighboring gene predicted gene, 41025 Neighboring gene STARR-positive B cell enhancer ABC_E10808 Neighboring gene small nucleolar RNA, H/ACA box 47 Neighboring gene zinc finger, BED type containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structure and function of WD40 domain proteins. Xu C, et al. Protein Cell, 2011 Mar. PMID 21468892, Free PMC Article
    2. SMCR8 negatively regulates AKT and MTORC1 signaling to modulate lysosome biogenesis and tissue homeostasis. Lan Y, et al. Autophagy, 2019 May. PMID 30696333, Free PMC Article
    3. Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function. McAlpine W, et al. Proc Natl Acad Sci U S A, 2018 Dec 4. PMID 30442666, Free PMC Article
    4. The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis. Zhang Y, et al. Genes Dev, 2018 Jul 1. PMID 29950492, Free PMC Article
    5. A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy. Yang M, et al. Sci Adv, 2016 Sep. PMID 27617292, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of exocytosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of immune response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of autophagy NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Atg1/ULK1 kinase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of guanyl-nucleotide exchange factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 41

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172590.4 → NP_766178.2  WD repeat-containing protein 41

      See identical proteins and their annotated locations for NP_766178.2

      Status: VALIDATED

      Source sequence(s)
      AK046853, AK082348, AK149993, BM943554, BQ043504
      Consensus CDS
      CCDS56896.2
      UniProtKB/Swiss-Prot
      Q3UDP0, Q8C4F1, Q8C8K5
      Related
      ENSMUSP00000124033.2, ENSMUST00000160801.8
      Conserved Domains (2) summary
      sd00039
      Location:87 → 133
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:38 → 350
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      95112226..95161800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158015.1 → XP_036013908.1  WD repeat-containing protein 41 isoform X1

      UniProtKB/Swiss-Prot
      Q3UDP0, Q8C4F1, Q8C8K5
      Conserved Domains (2) summary
      sd00039
      Location:87 → 133
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:38 → 350
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_006517584.4 → XP_006517647.1  WD repeat-containing protein 41 isoform X2

      Conserved Domains (2) summary
      sd00039
      Location:98 → 154
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:87 → 304
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_004938023.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UDP0.1 GenPept UniProtKB/Swiss-Prot:Q3UDP0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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