ALCAM activated leukocyte cell adhesion molecule [Homo sapiens (human)] - Gene

Summary

Official Symbol: ALCAMprovided by HGNC
Official Full Name: activated leukocyte cell adhesion moleculeprovided by HGNC
Primary source: HGNC:HGNC:400
See related: Ensembl:ENSG00000170017 MIM:601662; AllianceGenome:HGNC:400
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MEMD; CD166
Summary: This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011]
Expression: Broad expression in lung (RPKM 33.7), brain (RPKM 28.3) and 24 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 3q13.11

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (105366909..105576900)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (108084937..108294916)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (105085753..105295744)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Clinical significance of CD166 and HER-2 in different types of gastric cancer.
Title: Clinical significance of CD166 and HER-2 in different types of gastric cancer.
ALCAM on human oligodendrocytes mediates CD4 T cell adhesion.
Title: ALCAM on human oligodendrocytes mediates CD4 T cell adhesion.
Expression of ALCAM in Clinical Colon Cancer and Relationship With Patients' Treatment Responses.
Title: Expression of ALCAM in Clinical Colon Cancer and Relationship With Patients' Treatment Responses.
ALCAM, Activated Leukocyte Cell Adhesion Molecule, in Clinical Gastric Cancer and Patient's Response to Chemotherapies.
Title: ALCAM, Activated Leukocyte Cell Adhesion Molecule, in Clinical Gastric Cancer and Patient's Response to Chemotherapies.
Increase of ALCAM and VCAM-1 in the plasma predicts the Alzheimer's disease.
Title: Increase of ALCAM and VCAM-1 in the plasma predicts the Alzheimer's disease.
Activated Leukocyte Cell Adhesion Molecule (ALCAM), a Potential 'Seed' and 'Soil' Receptor in the Peritoneal Metastasis of Gastrointestinal Cancers.
Title: Activated Leukocyte Cell Adhesion Molecule (ALCAM), a Potential 'Seed' and 'Soil' Receptor in the Peritoneal Metastasis of Gastrointestinal Cancers.
Intrahepatic activated leukocyte cell adhesion molecule induces CD6(high)CD4(+) T cell infiltration in autoimmune hepatitis.
Title: Intrahepatic activated leukocyte cell adhesion molecule induces CD6(high)CD4(+) T cell infiltration in autoimmune hepatitis.
Proteome profiling of enzalutamide-resistant cell lines and serum analysis identified ALCAM as marker of resistance in castration-resistant prostate cancer.
Title: Proteome profiling of enzalutamide-resistant cell lines and serum analysis identified ALCAM as marker of resistance in castration-resistant prostate cancer.
Gene variation impact on prostate cancer progression: Lymphocyte modulator, activation, and cell adhesion gene variant contribution.
Title: Gene variation impact on prostate cancer progression: Lymphocyte modulator, activation, and cell adhesion gene variant contribution.
Urine ALCAM, PF4 and VCAM-1 Surpass Conventional Metrics in Identifying Nephritis Disease Activity in Childhood-Onset Systemic Lupus Erythematosus.
Title: Urine ALCAM, PF4 and VCAM-1 Surpass Conventional Metrics in Identifying Nephritis Disease Activity in Childhood-Onset Systemic Lupus Erythematosus.

Submit: New GeneRIF Correction See all GeneRIFs (147)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. EBI GWAS Catalog EBI GWAS CatalogPubMed
Pilot genome-wide association search identifies potential loci for risk of erectile dysfunction in type 1 diabetes using the DCCT/EDIC study cohort. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction	Pubs
Knockdown of activated leukocyte cell adhesion molecule (ALCAM) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH46353 (e-PCR)
- UniSTS:31542

SHGC-106342 (e-PCR)
- UniSTS:169795

D3S4183 (e-PCR)
- UniSTS:83048

SGC38382 (e-PCR)
- UniSTS:52850

WIAF-1714 (e-PCR)
- UniSTS:53373

STS-W51882 (e-PCR)
- UniSTS:25470

SHGC-132061 (e-PCR)
- UniSTS:170624

SHGC-83798 (e-PCR)
- UniSTS:101782

G59557 (e-PCR)
- UniSTS:136861

SHGC-35488 (e-PCR)
- UniSTS:23711

ALCAM_699 (e-PCR)
- UniSTS:276986

ALCAM_V72 (e-PCR)
- UniSTS:276986

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in axon extension involved in axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IEA Inferred from Electronic Annotation more info
involved_in neuron projection extension	ISS Inferred from Sequence or Structural Similarity more info
involved_in retinal ganglion cell axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of T cell receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in focal adhesion	HDA more info	PubMed
located_in immunological synapse	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: CD166 antigen

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029729.2 RefSeqGene

Range

5002..214993

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001243280.2 → NP_001230209.1 CD166 antigen isoform 2 precursor

See identical proteins and their annotated locations for NP_001230209.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the 3' CDS, compared to variant 1. The resulting isoform (2) lacks an internal segment in the C-terminal region, compared to isoform 1.

Source sequence(s)

AC023602, AC078806

Consensus CDS

CCDS58841.1

UniProtKB/TrEMBL

B3KNN9

Related

ENSP00000419236.2, ENST00000472644.6

Conserved Domains (5) summary

smart00406
Location:38 → 113

IGv; Immunoglobulin V-Type

smart00410
Location:255 → 329

IG_like; Immunoglobulin like

pfam08205
Location:137 → 231

C2-set_2; CD80-like C2-set immunoglobulin domain

pfam13927
Location:256 → 313

Ig_3; Immunoglobulin domain

cl11960
Location:415 → 488

Ig; Immunoglobulin domain
NM_001243281.2 → NP_001230210.1 CD166 antigen isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) has a shorter and different 3' sequence, compared to variant 1. The resulting isoform (3) is truncated at the C-terminus, compared to isoform 1.

Source sequence(s)

AC023602, AC078806, KF457664

UniProtKB/TrEMBL

B3KNN9

Conserved Domains (5) summary

smart00406
Location:38 → 113

IGv; Immunoglobulin V-Type

smart00410
Location:255 → 329

IG_like; Immunoglobulin like

pfam08205
Location:137 → 231

C2-set_2; CD80-like C2-set immunoglobulin domain

pfam13927
Location:256 → 313

Ig_3; Immunoglobulin domain

cl11960
Location:415 → 488

Ig; Immunoglobulin domain
NM_001243283.2 → NP_001230212.1 CD166 antigen isoform 4 precursor

See identical proteins and their annotated locations for NP_001230212.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks multiple 3' exons, and has an alternate 3' sequence, compared to variant 1. The resulting isoform (4) is the shortest; it is truncated at the C-terminus, compared to isoform 1.

Source sequence(s)

AY644765, BC041127, DA318514

UniProtKB/Swiss-Prot

Q13740

Related

ENST00000470756.5

Conserved Domains (2) summary

smart00406
Location:38 → 113

IGv; Immunoglobulin V-Type

smart00410
Location:36 → 130

IG_like; Immunoglobulin like
NM_001627.4 → NP_001618.2 CD166 antigen isoform 1 precursor

See identical proteins and their annotated locations for NP_001618.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC023602, AC078806

Consensus CDS

CCDS33810.1

UniProtKB/Swiss-Prot

B2RNS3, B4DTU0, O60892, Q13740, Q1HGM8, Q1HGM9, Q6PEY4, Q6ZS95

UniProtKB/TrEMBL

B3KNN9

Related

ENSP00000305988.5, ENST00000306107.9

Conserved Domains (6) summary

smart00406
Location:38 → 113

IGv; Immunoglobulin V-Type

smart00409
Location:255 → 329

IG; Immunoglobulin

smart00410
Location:339 → 393

IG_like; Immunoglobulin like

pfam08205
Location:137 → 231

C2-set_2; CD80-like C2-set immunoglobulin domain

pfam13927
Location:415 → 489

Ig_3; Immunoglobulin domain

cd00096
Location:128 → 132

Ig; Ig strand A [structural motif]