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    TPT1 tumor protein, translationally-controlled 1 [ Homo sapiens (human) ]

    Gene ID: 7178, updated on 11-Apr-2024

    Summary

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    Official Symbol
    TPT1provided by HGNC
    Official Full Name
    tumor protein, translationally-controlled 1provided by HGNC
    Primary source
    HGNC:HGNC:12022
    See related
    Ensembl:ENSG00000133112 MIM:600763; AllianceGenome:HGNC:12022
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HRF; p02; p23; TCTP
    Summary
    This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
    Expression
    Ubiquitous expression in ovary (RPKM 496.6), thyroid (RPKM 416.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    13q14.13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (45333471..45341183, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (44553718..44561430, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (45907606..45915318, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene general transcription factor IIF subunit 2 Neighboring gene uncharacterized LOC124903168 Neighboring gene uncharacterized LOC105370190 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr13:45883380-45884072 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:45904287-45904787 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:45914388-45915177 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5315 Neighboring gene uncharacterized LOC124903169 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:45916757-45917544 Neighboring gene small nucleolar RNA, H/ACA box 31B Neighboring gene small nucleolar RNA, H/ACA box 31 Neighboring gene TPT1 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:45941608-45942114 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:45944664-45945164 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:45945165-45945665 Neighboring gene Sharpr-MPRA regulatory region 12652 Neighboring gene reticulocalbin 1 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Polymorphisms in TPT1 Pathways in Pediatric Astrocytomas. Morais de Castro E, et al. ASN Neuro, 2023 Jan-Dec. PMID 36714975, Free PMC Article
    2. Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells. Hangai S, et al. Nat Immunol, 2021 Aug. PMID 34239121
    3. The mRNA of TCTP functions as a sponge to maintain homeostasis of TCTP protein levels in hepatocellular carcinoma. Liu W, et al. Cell Death Dis, 2020 Nov 12. PMID 33184257, Free PMC Article
    4. TCTP participates in hepatic metabolism by regulating gene expression involved in insulin resistance. Dong K, et al. Gene, 2021 Feb 5. PMID 33122078
    5. Conformational Ensemble and Biological Role of the TCTP Intrinsically Disordered Region: Influence of Calcium and Phosphorylation. Malard F, et al. J Mol Biol, 2018 May 25. PMID 29719201

    See all (187) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Elevated translationally controlled tumour protein promotes oral cancer progression and poor outcome.
      Title: Elevated translationally controlled tumour protein promotes oral cancer progression and poor outcome.
    2. METTL13 promotes nasopharyngeal carcinoma progression through regulating the ZEB1/TPT1 axis.
      Title: METTL13 promotes nasopharyngeal carcinoma progression through regulating the ZEB1/TPT1 axis.
    3. Polymorphisms in TPT1 Pathways in Pediatric Astrocytomas.
      Title: Polymorphisms in TPT1 Pathways in Pediatric Astrocytomas.
    4. Fortilin interacts with TGF-beta1 and prevents TGF-beta receptor activation.
      Title: Fortilin interacts with TGF-β1 and prevents TGF-β receptor activation.
    5. MiR-216a-5p inhibits tumorigenesis in Pancreatic Cancer by targeting TPT1/mTORC1 and is mediated by LINC01133.
      Title: MiR-216a-5p inhibits tumorigenesis in Pancreatic Cancer by targeting TPT1/mTORC1 and is mediated by LINC01133.
    6. Long non-coding RNA TPT1-AS1 sensitizes breast cancer cell to paclitaxel and inhibits cell proliferation by miR-3156-5p/caspase 2 axis.
      Title: Long non-coding RNA TPT1-AS1 sensitizes breast cancer cell to paclitaxel and inhibits cell proliferation by miR-3156-5p/caspase 2 axis.
    7. The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state.
      Title: The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state.
    8. Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells.
      Title: Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells.
    9. Guizhi Fuling pills inhibit the proliferation, migration and invasion of human cutaneous malignant melanoma cells by regulating the molecular axis of LncRNA TPT1-AS1 / miR-671-5p.
      Title: Guizhi Fuling pills inhibit the proliferation, migration and invasion of human cutaneous malignant melanoma cells by regulating the molecular axis of LncRNA TPT1-AS1 / miR-671-5p.
    10. The mRNA of TCTP functions as a sponge to maintain homeostasis of TCTP protein levels in hepatocellular carcinoma.
      Title: The mRNA of TCTP functions as a sponge to maintain homeostasis of TCTP protein levels in hepatocellular carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (106)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of tumor protein, translationally-controlled 1 (TPT1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ27337

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in intracellular calcium ion homeostasis IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in response to virus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in multivesicular body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translationally-controlled tumor protein
    Names
    fortilin
    histamine-releasing factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286272.2 → NP_001273201.1  translationally-controlled tumor protein isoform 1

      See identical proteins and their annotated locations for NP_001273201.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL138963
      Consensus CDS
      CCDS73566.1
      UniProtKB/TrEMBL
      A0A0B4J2C3, Q5W0H4
      Related
      ENSP00000477781.1, ENST00000616577.4
      Conserved Domains (1) summary
      pfam00838
      Location:1 → 167
      TCTP; Translationally controlled tumor protein

    2. NM_001286273.2 → NP_001273202.1  translationally-controlled tumor protein isoform 3

      See identical proteins and their annotated locations for NP_001273202.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains multiple differences in the coding region, compared to variant 1, including initiation of translation at a downstream in-frame start codon. The encoded isoform (3) has shorter N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AL138963, BC022436
      Consensus CDS
      CCDS66538.1
      Related
      ENSP00000368345.1, ENST00000379056.5
      Conserved Domains (1) summary
      pfam00838
      Location:1 → 133
      TCTP; Translationally controlled tumor protein

    3. NM_003295.4 → NP_003286.1  translationally-controlled tumor protein isoform 2

      See identical proteins and their annotated locations for NP_003286.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter C-terminus than isoform 1.
      Source sequence(s)
      AL138963, BP215975, X16064
      Consensus CDS
      CCDS9397.1
      UniProtKB/Swiss-Prot
      B2R7E5, P13693, Q6YLS2, Q7Z4J4, Q8TBK7, Q96EE2, Q9UC70
      UniProtKB/TrEMBL
      A0A0P1J1R0, Q5W0H4
      Related
      ENSP00000431872.2, ENST00000530705.6
      Conserved Domains (1) summary
      pfam00838
      Location:1 → 167
      TCTP; Translationally controlled tumor protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      45333471..45341183 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      44553718..44561430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13693.1 GenPept UniProtKB/Swiss-Prot:P13693

    Gene LinkOut

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