Ctse cathepsin E [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctseprovided by MGI
Official Full Name: cathepsin Eprovided by MGI
Primary source: MGI:MGI:107361
See related: Ensembl:ENSMUSG00000004552 AllianceGenome:MGI:107361
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CE; CatE; A430072O03Rik; C920004C08Rik
Summary: This gene encodes a member of the peptidase A1 family of aspartate proteases and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. Homozygous knockout mice for this gene exhibit lysosomal storage disorder, impaired autophagy, mitochondrial abnormalities, dermatitis, and reduced weight gain in an obesity model. [provided by RefSeq, Aug 2015]
Expression: Biased expression in stomach adult (RPKM 438.1), bladder adult (RPKM 70.7) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 57.14 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (131566052..131603245)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (131638314..131675507)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of Cathepsin E gene expression by the transcription factor Kaiso in MRL/lpr mice derived CD4+ T cells.
Title: Regulation of Cathepsin E gene expression by the transcription factor Kaiso in MRL/lpr mice derived CD4+ T cells.
Cathepsin-E deficient animals were highly resistant to (MOG35-55) induced mechanical allodynia.
Title: Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis.
Infact, decreased CtsE expression levels in BMDM of V30Mmice and their apparent impairment observed to LPSresponse could explain the mechanism for lower immunecell chemotaxis and impaired macrophage function observedin familial amyloid polyneuropathy.
Title: Downregulated Cathepsin E expression in bone marrow-derived macrophages from the pre-clinical familial amyloid polyneuropathy model.
Cathepsin E, mitochondrial fission, and caspase activation/apoptosis are linked in the pathogenesis of pulmonary emphysema.
Title: Cathepsin E promotes pulmonary emphysema via mitochondrial fission.
These results indicate that cathepsin E deficiency causes autophagy impairment concomitantly with increased aberrant mitochondria as well as increased oxidative stress.
Title: Cathepsin E deficiency impairs autophagic proteolysis in macrophages.
impaired adipose tissue development in high fat diet-induced CatE(-/-) mice was probably due to reduced infiltration of macrophages and may lead to hepatomegaly accompanied by hepatic steatosis and hypercholesterolemia
Title: Defective adipose tissue development associated with hepatomegaly in cathepsin E-deficient mice fed a high-fat diet.
L1 stimulation triggers sumoylation and cleavage of L1, thus generating the L1-70 fragment which is cleaved by cathepsin E
Title: Cathepsin E generates a sumoylated intracellular fragment of the cell adhesion molecule L1 to promote neuronal and Schwann cell migration as well as myelination.
Intradermal cathepsin E has pruritogenic activity, which is at least partly mediated by the production of endothelin-1.
Title: Cathepsin E induces itch-related response through the production of endothelin-1 in mice.
Low expression levels of MHC class II and cathepsin E might contribute to the defect in induction of Ag-specific T cells in NC mice.
Title: Decreased expression of MHC class II and cathepsin E in dendritic cells might contribute to impaired induction of antigen-specific T cell response in NC/Nga mice.
Results suggest that Sp1 binding plays a particularly important role in the regulation of cathepsin E gene expression.
Title: Role of the transcription factor Sp1 in regulating the expression of the murine cathepsin E gene.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Targeted (2) 1 citation
Not Applicable (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

BB210543 (e-PCR)
- UniSTS:207205

X97399 (e-PCR)
- UniSTS:163261

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aspartic-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables aspartic-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA Inferred from Direct Assay more info	PubMed
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	ISO Inferred from Sequence Orthology more info
involved_in protein autoprocessing	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cathepsin E

NP_031825.2

EC 3.4.23.34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007799.3 → NP_031825.2 cathepsin E preproprotein

See identical proteins and their annotated locations for NP_031825.2

Status: REVIEWED

Source sequence(s)

AC120217, AC138277, AK145875

Consensus CDS

CCDS15271.1

UniProtKB/Swiss-Prot

O35647, P70269, Q3UKT5, Q4FK00

UniProtKB/TrEMBL

D3Z6T3

Related

ENSMUSP00000073072.7, ENSMUST00000073350.13

Conserved Domains (3) summary

pfam00026
Location:78 → 395

Asp; Eukaryotic aspartyl protease

pfam07966
Location:22 → 50

A1_Propeptide; A1 Propeptide

cl11403
Location:79 → 394

pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases