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    Myl10 myosin, light chain 10, regulatory [ Mus musculus (house mouse) ]

    Gene ID: 59310, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Myl10provided by MGI
    Official Full Name
    myosin, light chain 10, regulatoryprovided by MGI
    Primary source
    MGI:MGI:1891705
    See related
    Ensembl:ENSMUSG00000005474 AllianceGenome:MGI:1891705
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PLRLC; Mylc2pl; 1700027I08Rik
    Summary
    Predicted to enable calcium ion binding activity. Located in mitochondrion. Orthologous to human MYL10 (myosin light chain 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 7.7) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 G2; 5 76.03 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (136717749..136730711)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (136688892..136701857)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene cut-like homeobox 1 Neighboring gene STARR-seq mESC enhancer starr_14620 Neighboring gene predicted gene, 54307 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:137026660-137026843 Neighboring gene STARR-seq mESC enhancer starr_14621 Neighboring gene STARR-positive B cell enhancer ABC_E4794 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:137093643-137093839 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:137093950-137094103 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:137099197-137099306 Neighboring gene predicted gene, 38722 Neighboring gene collagen, type XXVI, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_14627 Neighboring gene VISTA enhancer mm1626 Neighboring gene predicted gene, 30654 Neighboring gene predicted gene 20485

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible. Oltz EM, et al. EMBO J, 1992 Jul. PMID 1628631, Free PMC Article
    2. Protein partners of dynamin-1 in the retina. Grossman GH, et al. Vis Neurosci, 2013 Jul. PMID 23746204, Free PMC Article
    3. Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca(2+)/CaM) and CaM Kinase II (CaMKII) Binding Partner. Evans PR, et al. J Proteome Res, 2018 Apr 6. PMID 29518331, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myosin regulatory light chain 10
    Names
    myosin light chain 2, precursor lymphocyte-specific
    precursor lymphocyte-specific regulatory light chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085387.2 → NP_001078856.1  myosin regulatory light chain 10 isoform 2

      See identical proteins and their annotated locations for NP_001078856.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2, also known as "PLRLC-A") uses an alternate 5' terminal exon resulting in a distinct 5' UTR and the use of an in-frame downstream start codon, compared to variant 1. This results in isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same isoform (2).
      Source sequence(s)
      AC087329, CJ236701
      Consensus CDS
      CCDS80434.1
      UniProtKB/Swiss-Prot
      Q62082
      Related
      ENSMUSP00000143165.2, ENSMUST00000197186.2
      Conserved Domains (1) summary
      COG5126
      Location:1 → 128
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. NM_001303019.1 → NP_001289948.1  myosin regulatory light chain 10 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3, also known as "PLRLC-C") contains an alternate exon in the central coding region which results in a frameshift, compared to variant 1. This results in isoform 3 which is shorter and has a unique C-terminus compared to isoform 1.
      Source sequence(s)
      AC087329, CJ236701
      Consensus CDS
      CCDS80433.1
      UniProtKB/TrEMBL
      A0A0G2JDZ4
      Related
      ENSMUSP00000142570.2, ENSMUST00000196068.5
      Conserved Domains (1) summary
      cd00051
      Location:9 → 67
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    3. NM_001303021.1 → NP_001289950.1  myosin regulatory light chain 10 isoform 2

      See identical proteins and their annotated locations for NP_001289950.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' terminal exon resulting in a distinct 5' UTR and the use of an in-frame downstream start codon, compared to variant 1. This results in isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same isoform (2).
      Source sequence(s)
      CJ236701
      Consensus CDS
      CCDS80434.1
      UniProtKB/Swiss-Prot
      Q62082
      Related
      ENSMUSP00000142495.2, ENSMUST00000196436.5
      Conserved Domains (1) summary
      COG5126
      Location:1 → 128
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    4. NM_021611.3 → NP_067624.2  myosin regulatory light chain 10 isoform 1

      See identical proteins and their annotated locations for NP_067624.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC087329, CJ236701
      Consensus CDS
      CCDS51668.1
      UniProtKB/TrEMBL
      E9QNY3
      Related
      ENSMUSP00000005611.6, ENSMUST00000005611.10
      Conserved Domains (1) summary
      COG5126
      Location:1 → 144
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      136717749..136730711
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321050.2 → XP_017176539.1  myosin regulatory light chain 10 isoform X1

      Conserved Domains (1) summary
      COG5126
      Location:44 → 164
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. XM_017321051.3 → XP_017176540.2  myosin regulatory light chain 10 isoform X2

      Conserved Domains (1) summary
      COG5126
      Location:20 → 123
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62082.1 GenPept UniProtKB/Swiss-Prot:Q62082

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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