Ggta1 glycoprotein galactosyltransferase alpha 1, 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ggta1provided by MGI
Official Full Name: glycoprotein galactosyltransferase alpha 1, 3provided by MGI
Primary source: MGI:MGI:95704
See related: Ensembl:ENSMUSG00000035778 AllianceGenome:MGI:95704
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gal; GALT; Ggta; Ggta-1; alpha Gal; alpha3GalT
Summary: This gene encodes a member of the galactosyltransferase family of intracellular, membrane-bound enzymes that are involved in the biosynthesis of glycoproteins and glycolipids. The encoded protein catalyzes the transfer of galactose from UDP-galactose to N-acetyllactosamine in an alpha(1,3) linkage to form galactose alpha(1,3)-galactose. Mice lacking the encoded protein develop cortical cataracts. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2015]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 6.2), lung adult (RPKM 5.8) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 23.6 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (35290191..35354393, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (35400179..35464381, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Report immune responses and calcification in bovine/porcine heart valves implanted in alpha1,3-galactosyltransferase knockout mice.
Title: The Immune Responses and Calcification of Bioprostheses in the α1,3-Galactosyltransferase Knockout Mouse.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Mit515 (e-PCR), detects polymorphism
- UniSTS:129434

AW108479 (e-PCR)
- UniSTS:178618

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetyllactosaminide 3-alpha-galactosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hexosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid glycosylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi cisterna	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: N-acetyllactosaminide alpha-1,3-galactosyltransferase

Names: UDP-galactose:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase; glycoprotein alpha galactosyl transferase 1

NP_001139293.1

EC 2.4.1.87

NP_001295228.1

EC 2.4.1.87

NP_001295229.1

EC 2.4.1.87

NP_001407194.1

EC 2.4.1.87

NP_001407195.1

EC 2.4.1.87

NP_001407196.1

EC 2.4.1.87

NP_001407197.1

EC 2.4.1.87

NP_001407198.1

EC 2.4.1.87

NP_001407199.1

EC 2.4.1.87

NP_001407200.1

EC 2.4.1.87

NP_001407201.1

EC 2.4.1.87

NP_001407202.1

EC 2.4.1.87

NP_001407206.1

EC 2.4.1.87

NP_001407207.1

EC 2.4.1.87

NP_034413.2

EC 2.4.1.87

XP_011237329.1

EC 2.4.1.87

XP_011237330.1

EC 2.4.1.87

XP_011237331.1

EC 2.4.1.87

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145821.3 → NP_001139293.1 N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 2

See identical proteins and their annotated locations for NP_001139293.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 7 both encode the same isoform (2).

Source sequence(s)

AL929076, AL929199

Consensus CDS

CCDS50576.1

UniProtKB/Swiss-Prot

P23336, Q91V22

UniProtKB/TrEMBL

Q3TXW0

Related

ENSMUSP00000108626.3, ENSMUST00000113002.9

Conserved Domains (1) summary

pfam03414
Location:71 → 392

Glyco_transf_6; Glycosyltransferase family 6
NM_001308299.2 → NP_001295228.1 N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 3

See identical proteins and their annotated locations for NP_001295228.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.

Source sequence(s)

AL929076, AL929199

Consensus CDS

CCDS79787.1

UniProtKB/TrEMBL

A2AUR0, Q8C2H7

Related

ENSMUSP00000108625.3, ENSMUST00000113001.9

Conserved Domains (1) summary

pfam03414
Location:81 → 382

Glyco_transf_6; Glycosyltransferase family 6
NM_001308300.2 → NP_001295229.1 N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 4

See identical proteins and their annotated locations for NP_001295229.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1. Variants 4 and 8 both encode the same isoform (4).

Source sequence(s)

AL929076, AL929199

Consensus CDS

CCDS79786.1

UniProtKB/TrEMBL

Q91W00

Related

ENSMUSP00000078393.5, ENSMUST00000079424.11

Conserved Domains (1) summary

pfam03414
Location:69 → 370

Glyco_transf_6; Glycosyltransferase family 6
NM_001420265.1 → NP_001407194.1 N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 5, and 6 all encode the same isoform (1).

Source sequence(s)

AL929076, AL929199

UniProtKB/TrEMBL

Q9DBU1
NM_001420266.1 → NP_001407195.1 N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 5, and 6 all encode the same isoform (1).

Source sequence(s)

AL929199

UniProtKB/TrEMBL

Q9DBU1
NM_001420267.1 → NP_001407196.1 N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 2. Variants 2 and 7 both encode the same isoform (2).

Source sequence(s)

AL929076, AL929199

UniProtKB/Swiss-Prot

P23336, Q91V22

UniProtKB/TrEMBL

Q3TXW0
NM_001420268.1 → NP_001407197.1 N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 4. Variants 4 and 8 both encode the same isoform (4).

Source sequence(s)

AL929076, AL929199

UniProtKB/TrEMBL

Q91W00
NM_001420269.1 → NP_001407198.1 N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 5

Status: REVIEWED

Source sequence(s)

AL929076, AL929199
NM_001420270.1 → NP_001407199.1 N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 6

Status: REVIEWED

Source sequence(s)

AL929076, AL929199
NM_001420271.1 → NP_001407200.1 N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 6

Status: REVIEWED

Source sequence(s)

AL929076, AL929199
NM_001420272.1 → NP_001407201.1 N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 7

Status: REVIEWED

Source sequence(s)

AL929076, AL929199
NM_001420273.1 → NP_001407202.1 N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 7

Status: REVIEWED

Source sequence(s)

AL929076, AL929199
NM_001420277.1 → NP_001407206.1 N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 8

Status: REVIEWED

Source sequence(s)

AL929076, AL929199
NM_001420278.1 → NP_001407207.1 N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 8

Status: REVIEWED

Source sequence(s)

AL929076, AL929199
NM_010283.5 → NP_034413.2 N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 1

See identical proteins and their annotated locations for NP_034413.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 5, and 6 all encode the same isoform (1).

Source sequence(s)

AL929076, AL929199

Consensus CDS

CCDS15964.2

UniProtKB/TrEMBL

Q9DBU1

Related

ENSMUSP00000099858.2, ENSMUST00000102794.8

Conserved Domains (1) summary

pfam03414
Location:83 → 404

Glyco_transf_6; Glycosyltransferase family 6